Search Results (41)

Measuring limb joint angles is crucial for understanding horse conformation, performance, injury diagnosis, and prevention. While Thoroughbred horses have been extensively studied, local Pakistani breeds (e.g., Morna racehorse) have not received scientific attention. This study aimed to quantify normal angles of limb joints in the Morna breed. Limb joint angles of standing horses (n = 50) were quantified using a measuring tape, height stick, protractor scale, and goniometer. The mean and standard deviation (Mean ± SD) values for the forelimb joint angles were 123.02 ± 3.46° for elbow, 171.52 ± 2.39° for knee, and 147.68 ± 5.11° for fetlock. The mean ± SD values for the hindlimb joint angles were 128.62 ± 4.08° for stifle, 160.40 ± 3.89° for hock, and 155.48 ± 2.68° for fetlock. There was a non-significant (p > 0.05) correlation between horse joint angles and, age, body weight, and body condition score (BCS). The elbow and stifle joint angles of Morna align well with characteristics associated with optimal racing performance. However, the hock and fetlock angles differ from jumping Thoroughbred and French trotters. We recommend further research to examine the conformation of the Morna breed, particularly by measuring the lengths of limb segments and correlating it with joint angles. This may provide valuable insights into individual variations within the breed. Full article

COVID-19 is primarily a respiratory disease, but numerous studies have indicated the involvement of various organ systems during the course of illness. We conducted a comprehensive review of atypical complications of COVID-19 with their incidence range (IR) and their impact on hospitalization and mortality rates. We identified 97 studies, including 55 research articles and 42 case studies. We reviewed four major body organ systems for various types of atypical complications: (i) Gastro-intestinal (GI) and hepatobiliary system, e.g., bowel ischemia/infarction (IR: 1.49–83.87%), GI bleeding/hemorrhage (IR: 0.47–10.6%), hepatic ischemia (IR: 1.0–7.4%); (ii) Neurological system, e.g., acute ischemic stroke/cerebral venous sinus thrombosis/cerebral hemorrhage (IR: 0.5–90.9%), anosmia (IR: 4.9–79.6%), dysgeusia (IR: 2.8–83.38%), encephalopathy/encephalitis with or without fever and hypoxia (IR: 0.19–35.2%); (iii) Renal system, e.g., acute kidney injury (AKI)/acute renal failure (IR: 0.5–68.8%); (iv) Cardiovascular system, e.g., acute cardiac injury/non-coronary myocardial injury (IR: 7.2–55.56%), arrhythmia/ventricular tachycardia/ventricular fibrillation (IR: 5.9–16.7%), and coagulopathy/venous thromboembolism (IR: 19–34.4%). This review encourages and informs healthcare practitioners to keenly monitor COVID-19 survivors for these atypical complications in all major organ systems and not only treat the respiratory symptoms of patients. Post-COVID effects should be monitored, and follow-up of patients should be performed on a regular basis to check for long-term complications. Full article

In this article, a compact 4-port UWB (Ultra-Wide Band) MIMO (Multiple Input Multiple Output) antenna is proposed. A low profile FR-4 substrate is used as a dielectric material with the dimensions of 58 × 58 mm² (0.52λ × 0.52λ) at 2.8 GHz and a standard thickness of 1.6 mm. The proposed design characterizes an impedance bandwidth starting from 2.8 to 12.1 GHz (124.1%). Each of the four elements of the proposed MIMO antenna configuration consists of a monopole antenna with PG (partial ground) that has a slot at its center. The corner of each patch (radiator) and ground slot are rounded for impedance matching. Each unit cell is in an orthogonal orientation, forming a quad-port MIMO antenna system. For reference, the partial ground of each unit cell is connected meticulously with the others. The simulated results of the proposed quad-port MIMO antenna design were configured and validated by fabrication and testing. The proposed Quad-port MIMO design has a 6.57 dBi peak gain and 97% radiation efficiency. The proposed design has good isolation below 15 dB in the lower frequency range and below 20 dB in the higher frequency range. The design has a measured ECC (Envelop Correlation Co-efficient) of 0.03 and DG (Diversity Gain) of 10 dB. The value of TARC (Total Active Reflection Coefficient) over the entire operating band is less than 10 dB. Moreover, the design maintained CCL (Channel Capacity Loss) < 0.4 bits/sec/Hz and MEG (Mean Effective Gain) < 3 dB. Based on the obtained results, the proposed design is suitable for the intended high data rate UWB wireless communication portable devices. Full article

It has been observed from many pieces of research and through applications that robotic movements using human interaction are considered dangerous, tiresome and require extraordinary precision and smooth control. Specifically, medical and healthcare applications have been the highest priority in recent years. The concept of rehabilitation using robotics was introduced during the 1980s with the motive of freeing therapists from repetitive work while treating an increasing elderly population requiring physiotherapy. Furthermore, the consistency of the robot’s operation and the volume of repetitions has increased. They can assist therapists in performing tedious tasks and let them concentrate on several patients simultaneously. Several types of rehabilitation robot devices have been produced in recent years with different modes of training and control strategies using various control algorithms. In this research paper, a comprehensive overview of rehabilitation in relation to robotics is presented. The main aim is to determine robust controlling optimization for the smooth control of robotic movement, as these movements require a lot of precision and accuracy. The analysis showed that M-PSO was found to be very effective and robust in finding the best optimal values, as the Modified PSO achieved the minimum root mean square value and a best fit of 98.7. Full article

As the Urtica dioica L. whole plant’s essential oil has presented significant multiple activities, it was therefore evaluated using the GC–MS technique. This essential oil was investigated for its antioxidant, phytotoxic, and antibacterial activities in vitro. The GC–MS analysis data assisted in the identification of various constituents. The study of the essential oil of U. dioica showed potential antioxidant effects and antibacterial activity against the selected pathogens Escherichia coli -ATCC 9837 (E. coli), Bacillus subtilis-ATCC 6633 (B. subtilis), Staphylococcus aureus-ATCC6538 (S. aureus), Pseudomonas aeruginosa-ATCC 9027 (P. aeruginosa), and Salmonella typhi-ATCC 6539 (S. typhi). The library of 23 phytochemicals was docked by using MOE software, and three top virtual hits with peroxiredoxin protein [PDB ID: 1HD2] and potential target protein [PDB ID: 4TZK] were used; hence, the protein–ligand docking results estimated the best binding conformations and a significant correlation with the experimental analysis, in terms of the docking score and binding interactions with the key residues of the native active binding site. The essential oil in the silico pharmacokinetic profile explained the structure and activity relationships of the selected best hits, and their additional parameters provided insight for further clinical investigations. Therefore, it is concluded that the U. dioica essential oil could be a potent antioxidant and antibacterial agent for aromatherapy through its topical application, if further tested in a laboratory and validated. Full article

Freshwater scarcity is a global concern and is caused by the overuse of water, exceeding the sustainable level. In Pakistan, overpopulation, climate change alleviation, and economic development influence the asset of water. For water management, development, and conservation, policymakers need to formulate the right plans and projects. For this purpose, they need to evaluate the impact of different projects and plans and evaluate considerable data and information. Different tools are being adopted for integrated water resource management. Among them, WEAP is user-friendly, reliable, and efficient, and is used widely across the globe. It will aid the policymakers to develop suitable projects and plans. This study was carried out by using WEAP, in the Lower Bari Doab Canal command area (LBDC), Punjab, Pakistan. This study sheds light on the current water allocation situation and simulated scenarios of population growth rates and economic growth to evaluate the future water demand situation. The results of the current account year (2015) show that the domestic water demand of Okara (101.51 MCM) and the agricultural water demand (1713 MCM) of Sahiwal was seen to be the maximum among the four districts. Unmet demand was found to be maximum for the districts laying in the tail end (Sahiwal and Khanewal). The results of the scenarios show that, if the current water consumption, population growth, and economic development continue, unmet demand will increase in the future, and if the population grows at a higher rate and economic development increases, it will result in higher unmet water demand in the coming years. WEAP was found to be a user-friendly and efficient model to better understand water demand. Full article

(1) Background: The performance of estimated glomerular filtration rate (eGFR) equations in the Asian population has been widely questioned. The primary objective of this study was to gather evidence regarding optimal GFR equations in Asia for various age groups, disease conditions, and ethnicities. The secondary objective was to see whether the equations based on the combination of creatinine and cystatin C biomarkers if employed are satisfactory across different age groups and disease conditions in various ethnicities in Asia compared to those based on either of the single biomarkers. (2) Methods: Validation studies that had both creatinine and cystatin C-based equations either alone or in combination, validated in specific disease conditions, and those which compared the performance of these equations with exogenous markers were eligible only. The bias, precision, and 30% accuracy (P30) of each equation were recorded accordingly. (3) Results: Twenty-one studies consisting of 11,371 participants were included and 54 equations were extracted. The bias, precision, and P30 accuracies of the equations ranged from −14.54 to 9.96 mL/min/1.73 m², 1.61 to 59.85 mL/min/1.73 m², and 4.7% to 96.10%. The highest values of P30 accuracies were found for the JSN-CKDI equation (96.10%) in Chinese adult renal transplant recipients, for the BIS-2 equation (94.5%) in Chinese elderly CKD patients, and Filler equation (93.70%) also in Chinese adult renal transplant recipients. (4) Conclusions: Optimal equations were identified accordingly and it was proven that combination biomarker equations are more precise and accurate in most of the age groups and disease conditions. These can be considered equations of choice for the specific age groups, disease conditions, and ethnicities within Asia. Full article

Oral squamous cell carcinomas (OSCC) remain a major healthcare burden in Asian countries. In Pakistan alone, it is the most common cancer in males and second only to breast cancer in females. Alarmingly, treatment options for OSCC remain limited. With this context, investigations made to explore the inflammatory milieu of OSCC become highly relevant, with the hope of practicing immunotherapeutic approaches to address this highly prevalent tumor. We investigated the newly identified innate lymphoid cells (ILCs) and associated cytokines in well-defined human oral squamous cell carcinoma (OSCC) as well as in a 7,12-dimethylbenz[a]anthracene (DMBA)-induced murine model of OSCC using flow cytometry and quantitative real-time polymerase chain reaction (qPCR). We further went on to explore molecular circuitry involved in OSCC by developing a murine model of OSCC and using an α-Thy1 antibody to inhibit ILCs. Amongst the ILCs that we found in human OSCC, ILC3 (23%) was the most abundant, followed by ILC2 (17%) and ILC1 (1%). Mice were divided into four groups: DMBA (n = 33), DMBA+antibody (Ab) (n = 30), acetone (n = 5), and control (n = 5). In murine OSCC tissues, ILC1 and ILC3 were down-infiltrated, while ILC2 remained unchanged compared to controls. Interestingly, compared to the controls (DMBA group), mice treated with the α-Thy1 antibody showed fewer numbers of large tumors, and a larger percentage of these mice were tumor-free at this study’s end point. We present novel data on the differential expansion/downsizing of ILCs in OSCC, which provides a pivotal basis to dive deeper into molecular circuitry and the OSCC tumor niche to devise novel diagnostic, therapeutic, and prognostic strategies to prevent/treat oral cancers. Full article

A self-decoupled technique is described that enables the radiating elements in the antenna array to be densely packed for multiple-input multiple-output (MIMO) wireless communications systems. High isolation between the adjacent antenna elements is obtained by fixing the radiating elements in an orthogonal configuration with respects to each other. Current from the adjacent ports cancels their impact which results in low mutual coupling. The additional benefit of this configuration is realizing a densely packed array. The ground plane of each radiating element on the array board itself are isolated to mitigate surface wave propagations to suppress mutual coupling between the antenna elements. The radiating elements are based on a modified edge-fed circular patch antenna that includes a curved slot line and open-circuited stub to widen the array’s impedance bandwidth with no impact on the antenna’s footprint size. The proposed technique was verified with the design of an antenna array of matrix size 4 × 4 centered at 3.5 GHz. The array had a measured impedance bandwidth of 4 GHz from 1.5 GHz to 5.5 GHz, which corresponds to a fractional bandwidth of 114%, peak gain of 3 dBi and radiation efficiency of 84%. Its average diversity gain and envelope correlation coefficient (ECC) over its operating band are 9.6 dB and <0.016, respectively. The minimum isolation achieved between the radiating elements is better than 15 dB. The dimensions of the array are 0.4 × 0.4 × 0.039λ_g^3. The proposed array has characteristics suitable for sub-6 GHz wireless communication systems Full article

Groundwater pollution is considered a major concern in today’s world. Most industries in Pakistan produce untreated wastewater, extracting from and contaminating a nearby water source and the soil. This study was conducted in the Nithar Ke area of Chiniot District to assess the impact of the flow of wastewater over the area on groundwater quality. It aimed to: (1) investigate the conditions of industrial wastewater; (2) study the spatial variability of different parameters in groundwater using a GIS map; and (3) check the appropriateness of groundwater for drinking purposes using the water quality index (WQI). Physical and chemical characteristics, including pH, electrical conductivity, total dissolved solids, TSS, CO₃, HCO₃, chlorides, alkalinity, total hardness, Ca, Mg, arsenic, copper, chromium, nickel, iron, manganese, and sulfate, were tested using groundwater samples, and variance in groundwater was analyzed using a GIS (geographic information system). The water quality index (WQI) was developed for the Nithar Ke area to determine the appropriateness of the groundwater for drinking purposes. WQI values were determined within the range of 41 to 89.5, which showed a poor to good water quality. It was discovered that parameters such as BOD, COD, iron, and TDS had average concentrations of 192 mg/L, 264 mg/L, 2.62 mg/L, and 6039 mg/L, respectively, in the polluted water, which exceeded the permissible limit. Iron and manganese were the most common contaminants found in that area. The biplot and correlation circle showed that iron and turbidity had a positive relationship. Further study on soil stratification and soil characteristics is recommended in this area for a detailed analysis of the causes of metal contamination. Full article

Nanofluids have gained prominence due to their superior thermo-physical properties. The current paper deals with MHD nanofluid flow over a non-linear stretchable surface of varying thickness in the presence of an electric field. We investigated the effects of nanometer-sized copper (Cu) particles in water (base fluid) as a nanofluid, as well as non-linear thermal radiation, variable fluid viscosity, Joule heating, viscous dissipation, and non-uniform heat flux. The current study’s aim is influenced by the immense applications in industry and machine building. It has been observed that linear stretching sheets have been extensively used in heat transfer research. Moreover, no effort has been made yet to model a non-linear stretching sheet with variable thickness. Furthermore, the effects of electromagnetohydrodynamics (EMHD) boundary-layer flow of a nanofluid with the cumulative impact of thermal radiation, variable viscosity, viscous dissipation, Joule heating, and variable heat flux have been investigated. Sheets with variable thicknesses are practically significant in real-life applications and are being used in metallurgical engineering, appliance structures and patterns, atomic reactor mechanization and paper production. To investigate the physical features of the problem, we first examined the model and identified all the physical properties of the problem. This problem has been formulated using basic laws and governing equations. The partial differential equations (PDEs) that govern the flow are converted into a system of non-dimensional ordinary differential equations (ODE’s), using appropriate transformations. The Adam–Bashforth predictor-corrector technique and Mathematica software are utilized to numerically solve the resulting non-dimensionalized system. The interaction of various developing parameters with the flow is described graphically for temperature and velocity profiles. It is concluded that the velocity of nanoparticles declines as the intensity of the magnetic field increases. However, the temperature of the nanomaterials rises, as increasing the values of the electric field also increases the velocity distribution. The radiation parameter enhances the temperature field. The temperature of the fluid increases the occurrence of space- and time-dependent parameters for heat generation and absorption and radiation parameters. Full article

Air pollution is a global problem and the transportation industry is one of its major causes, yet the impact of transportation infrastructure on air quality is little understood. It is vital to know about evaluating the effects of transportation infrastructure on air quality. The urban road has a role in defining air pollution and automobiles significantly contribute to the air quality in urban areas. The issues are a result of the automobile’s impact on air quality. China put substantial investments in its metropolitan subway networks. The information on air quality on an hourly basis, daily metrological data, and demographic profiles of various cities with significant subways from the year 2013 to the year 2014 used. This study examines the effect of substantial investment on urban air quality. The Discontinuity Based Ordinary Least Squares (DB-OLS) on data for further analysis with results are incorporated in the study. The researchers witnessed a 14% reduction in air pollution during the daytime in those not rushed cities. Researchers discovered that the impacts are less severe in urban areas with a lower population density and a higher income. The results will be less dangerous if more subways affect the air quality. Full article

Autophagy plays an intricate role in paradigmatic human pathologies such as cancer, and neurodegenerative, cardiovascular, and autoimmune disorders. Autophagy regulation is performed by a set of autophagy-related (ATG) genes, first recognized in yeast genome and subsequently identified in other species, including humans. Several other genes have been identified to be involved in the process of autophagy either directly or indirectly. Studying the codon usage bias (CUB) of genes is crucial for understanding their genome biology and molecular evolution. Here, we examined the usage pattern of nucleotide and synonymous codons and the influence of evolutionary forces in genes involved in human autophagy. The coding sequences (CDS) of the protein coding human autophagy genes were retrieved from the NCBI nucleotide database and analyzed using various web tools and software to understand their nucleotide composition and codon usage pattern. The effective number of codons (ENC) in all genes involved in human autophagy ranges between 33.26 and 54.6 with a mean value of 45.05, indicating an overall low CUB. The nucleotide composition analysis of the autophagy genes revealed that the genes were marginally rich in GC content that significantly influenced the codon usage pattern. The relative synonymous codon usage (RSCU) revealed 3 over-represented and 10 under-represented codons. Both natural selection and mutational pressure were the key forces influencing the codon usage pattern of the genes involved in human autophagy. Full article

This work focuses on a compact circularly polarized wideband rectangular dielectric resonator antenna (RDRA) for X-band wireless applications. The wideband response of the RDRA is initially generated by a coaxial probe, a compact RDR, an air gap in the DR and a slot of rectangular shape in the ground. The circular polarization is achieved via incorporation of a unique feeding mechanism. The edge feeding of the RDRA with a coaxial probe generates the orthogonal modes in RDRA that make the design polarized circularly. The axial ratio performance is improved by adding a copper strip on the top of the DR. To validate the simulated results, the prototype design is fabricated and measured results are noted. For −10 dB reference value, the prototype has 59.74% impedance bandwidth (8.45–14.09 GHz). For 3 dB reference value of the axial ratio, the prototype has 9.24% Circular Polarization (CP) performance (10.084–11.084 GHz). The design has 6.5 dBic peak gain and 95.5% peak efficiency. Results show that simulated results are in close agreement with the measured results. Full article

Plastic waste accumulation has been recognized as one of the most critical challenges of modern societies worldwide. Traditional waste management practices include open burning, landfilling, and incineration, resulting in greenhouse gas emissions and economic loss. In contrast, emerging techniques for plastic waste management include microwave-assisted conversion, plasma-assisted conversion, supercritical water conversion, and photo reforming to obtain high-value products. Problems with poorly managed plastic waste are particularly serious in developing countries. This review article examines the emerging strategies and production of various high-value-added products from plastic waste. Additionally, the uses of plastic waste in different sectors, such as construction, fuel production, wastewater treatment, electrode materials, carbonaceous nanomaterials, and other high-value-added products are reviewed. It has been observed that there is a pressing need to utilize plastic waste for a circular economy and recycling for different value-added products. More specifically, there is limited knowledge on emerging plastic waste conversion mechanisms and efficiency. Therefore, this review will help to highlight the negative environmental impacts of plastic waste accumulation and the importance of modern techniques for waste management. Full article