Search Results (10)

The Module-0 Demonstrator is a single-phase 600 kg liquid argon time projection chamber operated as a prototype for the DUNE liquid argon near detector. Based on the ArgonCube design concept, Module-0 features a novel 80k-channel pixelated charge readout and advanced high-coverage photon detection system. In this paper, we present an analysis of an eight-day data set consisting of 25 million cosmic ray events collected in the spring of 2021. We use this sample to demonstrate the imaging performance of the charge and light readout systems as well as the signal correlations between the two. We also report argon purity and detector uniformity measurements and provide comparisons to detector simulations. Full article

The ENUBET project aims to reduce the flux-related systematics to 1% on a narrow band neutrino beam through monitoring the associated charged leptons in an instrumented decay tunnel. A key element of the project is the design of a meson transfer line with conventional magnets that maximize the yield of K${}^{+}$ and ${\pi }^{+}$ while minimizing the total length to reduce meson decay outside the instrumented region. In order to limit particle rates in the tunnel instrumentation, a high level of beam collimation is needed, thus allowing non-decayed mesons to reach the end of the tunnel. At the same time, fine-tuning of the shielding and the collimators is required to minimize any beam-induced background in the decay region. The magnetic lattice is optimized with TRANSPORT. The focusing of mesons from the target is performed with a static (quadrupole-based) system that, coupled with a slow proton extraction scheme, allows for a significant pile-up reduction at the tunnel instrumentation while retaining a particle yield large enough for high-precision neutrino cross-section measurements on a 3 year time scale. Charge and momentum selection in an 8.5GeV ± 10% momentum bite is performed by a double dipole system. Shielding elements are optimized with full simulation of the facility in Geant4. In particular, a powerful genetic algorithm is used to scan the parameter space of the collimators automatically in order to find a configuration that minimizes the halo background in the decay tunnel while preserving a large meson yield. This contribution will report the results of the optimization studies and the final design of the ENUBET beamline, together with dose estimation through a FLUKA simulation. The design of an alternative secondary beamline with a broad momentum range (4, 6, and 8.5 GeV/c) that could enhance the physics reach of the facility is additionally discussed. Full article

Monitored neutrino beams are facilities where beam diagnostics enable the counting and identification of charged leptons in the decay tunnel of a narrow band beam. These facilities can monitor neutrino production at the single particle level (flux precision $<1$%) and provide information about the neutrino energy at the 10% level. The ENUBET Collaboration has demonstrated that lepton monitoring might be achieved not only by employing kaon decays but also by identifying muons from the ${\pi }^{+}\to {\mu }^{+}{\nu }_{\mu }$ decays and positrons from the decay-in-flight of muons before the hadron dump. As a consequence, beam monitoring can be performed using the ENUBET technique even when the kaon production yield is kinematically suppressed. This finding opens up a wealth of opportunities for measuring neutrino cross-sections below 1 GeV. In this paper, we investigate this opportunity at the European Spallation Source (ESS), which is an ideal facility to measure ${\nu }_{\mu }$ and ${\nu }_e$ cross-sections in the 0.2–1 GeV range. We also describe the planned activities for the design of this beam at the ESS within the framework of the ESS$\nu$SB+ design study, which was approved by the EU in July 2022. Full article

The main source of systematic uncertainty on neutrino cross-section measurements at the GeV scale originates from the poor knowledge of the initial flux. The goal of reducing this uncertainty to 1% can be achieved through the monitoring of charged leptons produced in association with neutrinos, by properly instrumenting the decay region of a conventional narrow-band neutrino beam. Large-angle muons and positrons from kaons are measured by a sampling calorimeter on the decay tunnel walls, while muon stations after the hadron dump can be used to monitor the neutrino component from pion decays. Furthermore, the narrow momentum width (<10%) of the beam provides a O (10%) measurement of the neutrino energy on an event-by-event basis, thanks to its correlation with the radial position of the interaction at the neutrino detector. The ENUBET project has been funded by the ERC in 2016 to prove the feasibility of such a monitored neutrino beam and, since 2019, ENUBET is also a CERN neutrino platform experiment (NP06/ENUBET). The breakthrough the project achieved is the design of a horn-less neutrino beamline that would allow for a 1% measurement of ${\nu }_e$ and ${\nu }_{\mu }$ cross-sections in about 3 years of data taking at CERN-SPS, using ProtoDUNE as far detector. Full article

Background: This study compared the healing rates of lesser tuberosity osteotomy (LTO) for anatomic total shoulder arthroplasty (TSA), repaired with either standard knot tying or a tensionable construct. Second, we evaluated LTO healing in stemmed and stemless prostheses and identified the patient characteristics associated with healing. Methods: An analysis of consecutive primary TSAs approached with an LTO performed by a single surgeon between 2016 and 2020 was conducted. In the first two years of the study period, the LTOs were repaired with four #2 polyblend sutures passed through drill tunnels and around a short press-fit stem, followed by manual knot tying. Subsequently, a tensionable construct with suture tapes (TCB) was universally adopted. The radiographic appearance of the LTO was evaluated at a minimum of six months postoperatively. Results: A total of 340 patients met the study criteria, including 168 with manual knot tying, 84 TCB repairs with a stemmed implant, and 88 TCB repairs with a stemless implant. There was no difference in the baseline demographics between the groups. The LTO healing rate of the manual knot tying group (85%) was lower than that of the stemmed (95%) and stemless (98%) TCB groups (p < 0.001). When directly comparing the LTO healing between the stemmed and stemless TCB groups, the differences were not significant (p = 0.44). Across all constructs, the body mass index (BMI) was higher in the displaced nonunion group (p = 0.04), with a failure rate of 9.4% for a BMI between 30 and 40, 12.5% for a BMI between 40 and 50, and 28.6% for a BMI > 50. The rate of tobacco use was higher in the displaced nonunion group (p = 0.037). Conclusion: A tensionable construct improves LTO healing compared to manual knot tying, irrespective of the implant type. In addition to the surgical technique, the patient factors that influence tuberosity healing include a greater BMI and tobacco use. Level of evidence: Level III, retrospective comparative study. Full article

The Deep Underground Neutrino Experiment (DUNE) is an international, world-class experiment aimed at exploring fundamental questions about the universe that are at the forefront of astrophysics and particle physics research. DUNE will study questions pertaining to the preponderance of matter over antimatter in the early universe, the dynamics of supernovae, the subtleties of neutrino interaction physics, and a number of beyond the Standard Model topics accessible in a powerful neutrino beam. A critical component of the DUNE physics program involves the study of changes in a powerful beam of neutrinos, i.e., neutrino oscillations, as the neutrinos propagate a long distance. The experiment consists of a near detector, sited close to the source of the beam, and a far detector, sited along the beam at a large distance. This document, the DUNE Near Detector Conceptual Design Report (CDR), describes the design of the DUNE near detector and the science program that drives the design and technology choices. The goals and requirements underlying the design, along with projected performance are given. It serves as a starting point for a more detailed design that will be described in future documents. Full article

Objective. The purpose of this ex vivo study was to compare the trueness of traditional and digital workflows and to analyze the interfacial fit of CAD/CAM restorations on gypsum and 3D-printed casts (3DC). Methods: Forty patients underwent indirect posterior adhesive restorations. After tooth preparation, both traditional and chairside procedures were followed. Obtained models were scanned to generate STL files of the intraoral impression (IOS), the conventional cast (RS), and the 3D-printed cast (3DCS). Superimposition of the casts was performed to evaluate trueness. Then, for each preparation, two identical CAD/CAM restorations were milled and luted on RS and 3DC. Micro-CT scan was performed to evaluate 3D interfacial fit. Results. Surface trueness analysis showed no significant differences among groups (p > 0.05), with average trueness ranging from 11.56 to 17.01 µm. Micro-CT analysis showed significant differences between gypsum casts (average ranging from 135.78 to 212.31 µm) and 3DC (average ranging from 57.63 to 144.55 µm) for both marginal and internal fit. Conclusions. In adhesive restorations manufacturing, digital and conventional procedures generate casts that are not significantly different. Marginal fit of adhesive restorations is similar to conventional crown design and clinically acceptable. It is assumable that a direct digital workflow could benefit from the usage of 3DC. Full article

Objective: Wilms tumour (WT) patients with a localised completely necrotic nephroblastoma after preoperative chemotherapy are a favourable outcome group. Since the introduction of the SIOP 2001 protocol, the SIOP– Renal Tumour Study Group (SIOP–RTSG) has omitted radiotherapy for such patients with low-risk, local stage III in an attempt to reduce treatment burden. However, for metastatic patients with local stage III, completely necrotic WT, the recommendations led to ambiguous use. The purpose of this descriptive study is to demonstrate the outcomes of patients with metastatic, completely necrotic and local stage III WT in relation to the application of radiotherapy or not. Methods and materials: all metastatic patients with local stage III, completely necrotic WT after 6 weeks of preoperative chemotherapy who were registered in the SIOP 2001 study were included in this analysis. The pattern of recurrence according to the usage of radiation treatment and 5 year event-free survival (EFS) and overall survival (OS) was analysed. Results: seven hundred and three metastatic WT patients were registered in the SIOP 2001 database. Of them, 47 patients had a completely necrotic, local stage III WT: 45 lung metastases (11 combined localisations), 1 liver/peritoneal, and 1 tumour thrombus in the renal vein and the inferior vena cava with bilateral pulmonary arterial embolism. Abdominal radiotherapy was administered in 29 patients (62%; 29 flank/abdominal irradiation and 9 combined with lung irradiation). Eighteen patients did not receive radiotherapy. Median follow-up was 6.6 years (range 1–151 months). Two of the 47 patients (4%) developed disease recurrence in the lung (one combined with abdominal relapse) and eventually died of the disease. Both patients had received abdominal radiotherapy, one of them combined with lung irradiation. Five-year EFS and OS were 95% and 95%, respectively. Conclusions: the outcome of patients with stage IV, local stage III, completely necrotic Wilms tumours is excellent. Our results suggest that abdominal irradiation in this patient category may not be of added value in first-line treatment, consistent with the current recommendation in the SIOP–RTSG 2016 UMBRELLA protocol. Full article

Chemotherapy remains a primary treatment for metastatic cancer, with tumor response being the benchmark outcome marker. However, therapeutic response in cancer is unpredictable due to heterogeneity in drug delivery from systemic circulation to solid tumors. In this proof-of-concept study, we evaluated chemotherapy concentration at the tumor-site and its association with therapy response by applying a mathematical model. By using pre-treatment imaging, clinical and biologic variables, and chemotherapy regimen to inform the model, we estimated tumor-site chemotherapy concentration in patients with colorectal cancer liver metastases, who received treatment prior to surgical hepatic resection with curative-intent. The differential response to therapy in resected specimens, measured with the gold-standard Tumor Regression Grade (TRG; from 1, complete response to 5, no response) was examined, relative to the model predicted systemic and tumor-site chemotherapy concentrations. We found that the average calculated plasma concentration of the cytotoxic drug was essentially equivalent across patients exhibiting different TRGs, while the estimated tumor-site chemotherapeutic concentration (eTSCC) showed a quadratic decline from TRG = 1 to TRG = 5 (p < 0.001). The eTSCC was significantly lower than the observed plasma concentration and dropped by a factor of ~5 between patients with complete response (TRG = 1) and those with no response (TRG = 5), while the plasma concentration remained stable across TRG groups. TRG variations were driven and predicted by differences in tumor perfusion and eTSCC. If confirmed in carefully planned prospective studies, these findings will form the basis of a paradigm shift in the care of patients with potentially curable colorectal cancer and liver metastases. Full article

The purpose of our work was to select phages displaying peptides capable of binding to vascular markers present in human atheroma, and validate their capacity to target the vascular markers in vitro and in low-density lipoprotein receptor knockout (LDLr^−/−) mouse model of atherosclerosis. By peptide fingerprinting on human atherosclerotic tissues, we selected and isolated four different peptides sequences, which bind to atherosclerotic lesions and share significant similarity to known human proteins with prominent roles in atherosclerosis. The CTHRSSVVC-phage peptide displayed the strongest reactivity with human carotid atherosclerotic lesions (p < 0.05), when compared to tissues from normal carotid arteries. This peptide sequence shares similarity to a sequence present in the fifth scavenger receptor cysteine-rich (SRCR) domain of CD163, which appeared to bind to CD163, and subsequently, was internalized by macrophages. Moreover, the CTHRSSVVC-phage targets atherosclerotic lesions of a low-density lipoprotein receptor knockout (LDLr^−/−) mouse model of atherosclerosis in vivo to High-Fat diet group versus Control group. Tetraazacyclododecane-1,4,7,10-tetraacetic acid-CTHRSSVVC peptide (DOTA-CTHRSSVVC) was synthesized and labeled with ¹¹¹InCl₃ in >95% yield as determined by high performance liquid chromatography (HPLC), to validate the binding of the peptide in atherosclerotic plaque specimens. The results supported our hypothesis that CTHRSSVVC peptide has a remarkable sequence for the development of theranostics approaches in the treatment of atherosclerosis and other diseases. Full article