Search Results (4)

Background: folliculogenesis is a strictly regulated process that may be affected by endocrine disrupting chemicals (EDCs) through sometimes not so clear molecular mechanisms. Methods: we conducted a multicentric observational study involving six fertility centers across Italy, prospectively recruiting 122 women attending a fertility treatment. Recruited women had age ≤42 years, and normal ovarian reserve. Blood and follicular fluid samples were taken for EDCs measurement using liquid chromatography tandem mass spectrometry and each woman completed an epidemiological questionnaire. Results: The main EDCs found were monobutyl phthalate (MBP) (median blood: 8.96 ng/mL, follicular fluid 6.43 ng/mL), monoethylhexyl phthalate (MEHP) (median blood: 9.16 ng/mL, follicular fluid 7.68 ng/mL) and bisphenol A (BPA) (median blood: 1.89 ng/mL, follicular fluid 1.86 ng/mL). We found that serum MBP concentration was significantly associated with the considered area (p < 0.001, adj. mean: 7.61 ng/mL, 14.40 ng/mL, 13.56 ng/mL; Area 1: Milan–Turin, Area 2: Rome–Naples; Area 3: Catania–Bari, respectively) but negatively with home plastic food packaging (p = 0.004). Follicular MBP was associated with irregular cycles (p = 0.019). No association was detected between EDCs and eating habits and other clinical and epidemiological features. Conclusions: This study represents the first Italian biomonitoring of plastic EDCs in follicular fluid, laying the basis for future prospective evaluation on oocyte quality before assisted reproduction techniques (ART). Full article

Water leakages are one of the most significant uncertainties affecting water supply system (WSSs) modelling. Due to the dependence between water losses and pressure, the WSSs characterised by high values of pressure in the distribution network are strongly affected by this problem. High-pressure conditions are typical of WSSs in the mountain areas. In this study, a real WSS of the Alpine region is analysed through simultaneous calibration of water losses and pressure-reducing valves with a genetic algorithm. The demand is represented by a uniformly distributed along the network pipes scheme, dealing with the water request separately from the losses. Full article

The selective trapping and erosion of fine particles that occur in a gravel bed river have important consequences for its stream ecology, water quality, and overall sediment budgeting. This is particularly relevant in water bodies that experience periodic alternation between sediment supply-limited conditions and high sediment loads, such as downstream from a dam. While experimental efforts have been spent to investigate fine sediment erosion and transport in gravel bed rivers, a comprehensive overview of the leading processes is hampered by the difficulties in performing flow field measurements below the gravel crest level. In this work, a new two-dimensional, semi-implicit numerical scheme for the solution of the Navier-Stokes equations in the presence of deposited and erodible sediment is presented, and tested against analytical solutions and performing numerical tests. The scheme is mass-conservative, computationally efficient, and allows for a fine discretization of the computational domain. Overall, this makes the model suitable to appreciate small-scales phenomena such as inter-grain circulation cells, thus offering a valid alternative to evaluate the shear stress distribution, on which erosion and transport processes depend, compared to traditional experimental approaches. In this work, we present proof-of-concept of the proposed model, while future research will focus on its extension to a three-dimensional and parallelized version, and on its application to real case studies. Full article

The use of Pumps-as-Turbines (PaTs) to replace hydraulic turbines as energy-recovery units in industrial and civil applications is widening the penetration of hydropower in small-scale plants. PaTs show advantages in terms of installation costs and the availability of solutions. Water Distribution Networks (WDNs) represent a potential application where PaTs can be installed to recover water-pressure energy. In this work, a MATLAB©–Simulink model of a WDN branch located in South-Tyrol (Italy) was developed. The flow rate of the WDN was assessed though a measurement campaign showing high daily variability, which negatively affect PaT performance. To let the machine operate close to the Best Efficiency Point (BEP), four different operating strategies were studied to meet the constraint of a fixed pressure equal to 4 bar downstream the WDN branch, required to supply water to users. A PaT speed control strategy was implemented, granting better exploitation of flow rates even in the presence of high daily fluctuations. Energy recovery was 23% higher than that of the reference thanks to an advanced strategy based on controlling PaT rotational speed when the flow rate is smaller than that of the design, and operating in off-design conditions when flow rate is higher than that of the BEP. Full article