Search Results (5)

CANYVAL-C is a formation-flying mission that demonstrates a coronagraph utilizing two CubeSats. The coronagraph is a space telescope that blocks sunlight to examine the overcast regions around the sun. It is composed of optical and occult segments. Two spacecraft were aligned with respect to an inertial system to configure a virtual telescope using inertial alignment hold technology. The relative orbit control scenario for this mission involves rendezvous, differential air drag control, and inertial alignment holding. Orbit control algorithms and simple strategies that can be automatically constructed onboard have also been developed. For each maneuver, the control performance under the errors from navigation, attitude determination and control, and propulsion systems were assessed via Monte Carlo simulation, taking into account the hardware specifications and operations. In addition to the algorithm and strategy of this mission, the relative orbit control scenario was evaluated for its practicability using Monte Carlo simulations. The feasibility of this mission is ensured by a statistical analysis of the prospect of its success during its operation. Full article

Myxoma virus (MyxV) is a rabbit-specific poxvirus. However, its ability to selectively target tumor cells has established it as a safe and effective anticancer therapy. To strengthen its preclinical efficacy, transgenes that can prolong cancer cell infection and enhance anti-tumor effector functions are currently being investigated. We engineered MyxV armed with CD47, to turn on a ‘do not eat me’ signal within infected cells with actively replicating viruses, and with IFN-γ to further activate host immune anticancer responses. Tumor suppressive activities were significantly enhanced by the dual-armed MyxV_CD47/IFN-γ compared to parental MyxV or single-armed MyxV_CD47 or MyxV_IFN-γ. In addition, significant increases in IFN-γ+ CD8+T-cells and CD4+ T-cells populations within tumor-infiltrating lymphocytes (TIL) were observed after MyxV_CD47/IFN-γ treatment. Notably, all groups treated with MyxV showed a marked reduction in Foxp3+ CD4+ regulatory T-cells (Tregs) within TIL. We also show that MyxV infection induces PD-L1 up-regulation in cancer cells, and combinational treatment of MyxV with anti-mouse PD-L1 antibodies (αPD-L1) further controlled tumor burden and increased survival in the syngeneic melanoma model B16F10. Our data demonstrate that a CD47 and IFNγ dual-armed MyxV is an effective oncolytic viral immunotherapeutic. These findings strongly support further preclinical investigations to develop next-generation MyxV-based immunotherapy approaches. Full article

With growth in data volume from space missions, interest in laser communications has increased, owing to their importance for high-speed data transfer in the commercial and defense fields, spaceborne remote sensing, and surveillance. Here, we propose a novel system for space-to-space laser communication, a very high-speed inter-satellite link system using an infrared optical terminal and nanosatellite (VISION), which is aimed at establishing and validating miniaturized laser crosslink systems and several space technologies using two 6U nanosatellites in formation flying. An optical link budget analysis is conducted to derive the signal-to-noise ratio requirements and allocate the system budget; the optical link margin should be greater than 10 dB to guarantee communication with practical limitations. The payload is a laser transceiver with a deployable space telescope to enhance the gain of the beam transmission and reception. Nanosatellites, including precise formation flying GNC systems, are designed and analyzed. The attitude control system ensures pointing and tracking errors within tens of arcsec, and they are equipped with a propulsion system that can change the inter-satellite distance rapidly and accurately. This novel concept of laser crosslink systems is expected to make a significant contribution to the future design and construction of high-speed space-to-space networks. Full article

For the low-cost improvement of laser communication, which is critical for various applications such as surveillance systems, a study was conducted on relative distance control based on orbital drift rate modulations for multiple CubeSats during formation flying. The VISION mission covered in this paper comprises two CubeSats to demonstrate laser communication technology in space. During the mission, the deputy CubeSat changes the relative distance to execute mission objectives within various scenarios. Impulsive controls decrease, maintain, and increase the relative distance between the CubeSats by changing the orbital drift rates. The simulation results indicated that the desired orbital operation can be conducted within a given $\Delta \mathit{V}$ budget. In addition, the errors in the orbit determination, thrust maneuvers, and time synchronization were analyzed to satisfy the mission requirements. The mass-to-area ratio should be matched to adjust the relative distance between satellites with different properties by drift rate modulation. The proposed orbit control method appropriately operated the VISION mission by adjusting the drift rate modulation. The results of this study serve as a basis for the development of complex orbit control simulations and detailed designs that reflect the characteristics of the thrust module and operational aspects. Full article

The CANYVAL-C (CubeSat Astronomy by NASA and Yonsei using a virtual telescope alignment for coronagraph) is a space science demonstration mission that involves taking several images of the solar corona with two CubeSats—1U CubeSat (Timon) and 2U CubeSat (Pumbaa)—in formation flying. In this study, we developed and evaluated structural and thermal designs of the CubeSats Timon and Pumbaa through finite element analyses, considering the nonlinearity effects of the nylon wire of the deployable solar panels installed in Pumbaa. On-orbit thermal analyses were performed with an accurate analytical model for a visible camera on Timon and a micro propulsion system on Pumbaa, which has a narrow operating temperature range. Finally, the analytical models were correlated for enhancing the reliability of the numerical analysis. The test results indicated that the CubeSats are structurally safe with respect to the launch environment and can activate each component under the space thermal environment. The natural frequency of the nylon wire for the deployable solar panels was found to increase significantly as the wire was tightened strongly. The conditions of the thermal vacuum and cycling testing were implemented in the thermal analytical model, which reduced the differences between the analysis and testing. Full article