Search Results (5)

Background: Meropenem–vaborbactam (MEM-VAB) is a novel carbapenem-beta-lactamase-inhibitor combination that demonstrates activity against carbapenem-resistant (CR) Gram-negative bacteria, and more specifically KPC-producers, since vaborbactam is an effective inhibitor of KPC enzymes in vitro. This study aimed to describe the initial uses and efficacy of MEM-VAB for compassionate treatment during the first 21 months following its early access in France. Method: A national multicenter retrospective study was conducted, including all patients who received at least one dose of MEM-VAB between 20 July 2020, and 5 April 2022. Clinical characteristics and outcomes were collected using a standardized questionnaire. The minimum inhibitory concentration (MIC) of antimicrobials, and complete genome sequencing of bacteria were performed when bacterial isolates were available. Results: Ultimately, 21 patients from 15 French hospitals were included in the study. The main indication for MEM-VAB treatment was respiratory tract infections (n = 9). The targeted bacteria included Pseudomonas aeruginosa (n = 12), Klebsiella pneumoniae (n = 3), Enterobacter spp (n = 3), Citrobacter freundii (n = 1), Escherichia coli (n = 1), and Burkholderia multivorans (n = 1). Overall, no significant advantage of vaborbactam over meropenem alone was observed across all strains of P. aeruginosa in terms of in vitro susceptibility. However, MEM-VAB demonstrated a notable impact, compared to carbapenem alone, on the MIC for the two KPC-3-producing K. pneumoniae and B. multivorans. Conclusions: MEM-VAB seems effective as a salvage treatment in compassionate use, but vaborbactam was shown to lack benefits compared to meropenem in treating P. aeruginosa-related infections. Therefore, it is crucial to compare meropenem to MEM-VAB MICs, particularly for P. aeruginosa, before prescribing MEM-VAB. Full article

We measured the radiation tolerance of commercially available diamonds grown by the Chemical Vapor Deposition process by measuring the charge created by a 120 GeV hadron beam in a 50 $\mathsf{\mu }\mathrm{m}$ pitch strip detector fabricated on each diamond sample before and after irradiation. We irradiated one group of samples with 70 MeV protons, a second group of samples with fast reactor neutrons (defined as energy greater than $0.1$ MeV), and a third group of samples with 200 MeV pions, in steps, to ($8.8\pm 0.9$) × 10¹⁵ protons/cm², ($1.43\pm 0.14$) × 10¹⁶ neutrons/cm², and ($6.5\pm 1.4$) × 10¹⁴ pions/cm², respectively. By observing the charge induced due to the separation of electron–hole pairs created by the passage of the hadron beam through each sample, on an event-by-event basis, as a function of irradiation fluence, we conclude all datasets can be described by a first-order damage equation and independently calculate the damage constant for 70 MeV protons, fast reactor neutrons, and 200 MeV pions. We find the damage constant for diamond irradiated with 70 MeV protons to be $1.62\pm 0.07\left(\mathrm{stat}\right)\pm 0.16\left(\mathrm{syst}\right)\times$ 10⁻¹⁸ cm²$/(p\mathsf{\mu }\mathrm{m})$, the damage constant for diamond irradiated with fast reactor neutrons to be $2.65\pm 0.13\left(\mathrm{stat}\right)\pm 0.18\left(\mathrm{syst}\right)\times$ 10⁻¹⁸ cm²$/(n\mathsf{\mu }\mathrm{m})$, and the damage constant for diamond irradiated with 200 MeV pions to be $2.0\pm 0.2\left(\mathrm{stat}\right)\pm 0.5\left(\mathrm{syst}\right)\times$ 10⁻¹⁸ cm²$/(\pi \mathsf{\mu }\mathrm{m})$. The damage constants from this measurement were analyzed together with our previously published 24 GeV proton irradiation and 800 MeV proton irradiation damage constant data to derive the first comprehensive set of relative damage constants for Chemical Vapor Deposition diamond. We find 70 MeV protons are 2.60 ± 0.29 times more damaging than 24 GeV protons, fast reactor neutrons are 4.3 ± 0.4 times more damaging than 24 GeV protons, and 200 MeV pions are 3.2 ± 0.8 more damaging than 24 GeV protons. We also observe the measured data can be described by a universal damage curve for all proton, neutron, and pion irradiations we performed of Chemical Vapor Deposition diamond. Finally, we confirm the spatial uniformity of the collected charge increases with fluence for polycrystalline Chemical Vapor Deposition diamond, and this effect can also be described by a universal curve. Full article

Micrographic image analysis, tomography and the Archimedes method are commonly used to analyze the porosity of Selective Laser Melting (SLM)-produced parts and then to estimate the relative density. This article deals with the limitation of the relative density results to conclude on the quality of a part manufactured by additive manufacturing and focuses on the interpretation of the relative density result. To achieve this aim, two experimental methods are used: the image analysis method, which provides local information on the distribution of porosity, and the Archimedes method, which provides access to global information. To investigate this, two different grades of aluminum alloy, AlSi7Mg0.6 and AM205, were used in this study. The study concludes that an analysis of the metallographic images to calculate the relative density of the part depends on the areas chosen for the analysis. In addition, the results show that the Archimedes method has limitations, particularly related to the choice of reference materials for calculating relative density. It can be observed, for example, that, depending on the experimental conditions, the calculation can lead to relative densities higher than 100%, which is inconsistent. This article shows that it is essential that a result of relative density obtained from Archimedes measurements be supplemented by an indication of the reference density used. Full article

Dendrimers are nanosized, arborescent macromolecules synthesized in a stepwise fashion with attractive degrees of functionality and structure definition. This is one of the reasons why they are widely used for biomedical applications. Previously, we have shown that a poly(phosphorhydrazone) (PPH) dendrimer capped with anionic azabisphosphonate groups (so-called ABP dendrimer) has immuno-modulatory and anti-inflammatory properties towards human immune cells in vitro. Thereafter, we have shown that the ABP dendrimer has a promising therapeutic efficacy to treat models of acute and chronic inflammatory disorders in animal models. In these models, the active pharmaceutical ingredient was administered systematically (intravenous and oral administrations), but also loco-regionally in the vitreous tissue. Herein, we assessed the therapeutic efficacy of the ABP dendrimer in the preclinical mouse model of psoriasis induced by imiquimod. The ABP dendrimer was administered in phosphate-buffered saline solution via either systemic injection or topical application. We show that the topical application enabled the control of both the clinical and histopathological scores, and the control of the infiltration of macrophages in the skin of treated mice. Full article

In recent years, technological advancements have led to the industrialization of the laser powder bed fusion process. Despite all of the advancements, quality assurance, reliability, and lack of repeatability of the laser powder bed fusion process still hinder risk-averse industries from adopting it wholeheartedly. The process-induced defects or drifts can have a detrimental effect on the quality of the final part, which could lead to catastrophic failure of the finished part. It led to the development of in situ monitoring systems to effectively monitor the process signatures during printing. Nevertheless, post-processing of the in situ data and defect detection in an automated fashion are major challenges. Nowadays, many studies have been focused on incorporating machine learning approaches to solve this problem and develop a feedback control loop system to monitor the process in real-time. In our study, we review the types of process defects that can be monitored via process signatures captured by in situ sensing devices and recent advancements in the field of data analytics for easy and automated defect detection. We also discuss the working principles of the most common in situ sensing sensors to have a better understanding of the process. Commercially available in situ monitoring devices on laser powder bed fusion systems are also reviewed. This review is inspired by the work of Grasso and Colosimo, which presented an overall review of powder bed fusion technology. Full article