Multiple Micronutrient Powder Reduces Vitamin E Deficiency in Brazilian Children: A Pragmatic, Controlled Clinical Trial
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design and Population
2.2. Data Collection
2.3. Groups and Interventions
2.4. Anthropometric Assessment
2.5. Biochemical Assessment
2.6. Statistical Analysis
2.7. Ethical Aspects
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
AGP | Alpha-1-glycoprotein |
CG | Control group |
CRP | C-reactive protein |
ENFAC | Estudo Nacional de Fortificação Caseira da Alimentação Complementar |
ICF | Informed Consent Form |
HIV | Human Immunodeficiency Virus |
HPLC | High Performance Liquid Chromatography |
IG | Intervention group |
IRIS | International Research on Infant Supplementation |
IQR | Interquartile range |
PSE | Health at School Program |
PR | Prevalence ratio |
SD | Standard deviation |
WHO | World Health Organization |
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Variable | CG (n = 117) | IG (n = 107) | p Value |
---|---|---|---|
Age of child (months), mean, and SD | 13.65 ± 0.87 | 12.94 ± 0.94 | <0.001 1 |
Female gender, n (%) | 55 (47.01) | 53 (49.53) | 0.71 2 |
Birth weight, mean and SD | 3247.5 ± 469.8 | 3288.5 ± 426.1 | 0.49 3 |
Maternal education <9 years, n (%) | 33 (28.45) | 21 (19.81) | 0.13 2 |
Mother’s age (years), median (IQR) | 28 (24; 32) | 27 (22; 31) | 0.18 1 |
Current breastfeeding, n (%) | 67 (57.26) | 59 (55.14) | 0.75 2 |
Number of prenatal consultations, median (IQR) | 8 (6;10) | 8 (6;9) | 0.80 1 |
Race, n (%) | 0.95 4 | ||
White | 9 (7.76) | 10 (9.35) | |
Brown | 102 (87.93) | 93 (86.92) | |
Black | 5 (4.31) | 4 (3.74) |
Variable | CG (n = 117) | IG (n = 107) | p Value |
---|---|---|---|
Anthropometric data | |||
Weight (kg), mean and SD | 10.02 ± 1.20 | 9.85 ± 1.19 | 0.29 1 |
Length (cm), median (IQR) | 77 (75; 79) | 77.8 (75; 79.5) | 0.68 2 |
LAZ (Z-score), mean and SD | 0.07 ± 1.13 | 0.41 ± 1.09 | 0.02 1 |
Clinical data | |||
Presence of fever, n (%) | 39 (33.33) | 24 (22.43) | 0.07 3 |
Presence of cough, n (%) | 53 (45.30) | 21 (19.63) | <0.001 3 |
Presence of wheezing, n (%) | 35 (29.91) | 16 (14.95) | 0.008 3 |
Presence of diarrhea, n (%) | 27 (23.08) | 22 (20.56) | 0.65 3 |
Biochemical data | |||
Serum α-tocopherol (µmol/L), median (IQR) | 3.6 (0.09; 9.7) | 17.2 (12.9; 21.2) | <0.001 2 |
CRP (mg/L), median (IQR) | 0.5 (0.2; 1.5) | 0.3 (0.2; 1.0) | 0.19 2 |
AGP (mg/dL), median (IQR) | 74.5 (61.8; 109.5) | 72.4 (61.4; 92.3) | 0.08 2 |
Variable | CG (n = 117) | IG (n = 107) | p Value |
---|---|---|---|
Biochemical data | |||
Vitamin E deficiency (<11.6 µmol/L), n (%) | 95 (85.6) | 16 (14.4) | <0.001 1 |
Vitamin E deficiency, adjusted PR (95% CI) | 1 | 0.18 (0.11; 0.30) | <0.001 2 |
CRP > 5 mg/L, n (%) | 14 (12.39) | 6 (5.83) | 0.096 1 |
CRP > 5 mg/L, adjusted PR (95% CI) | 1 | 0.40 (0.13; 1.29) | 0.13 2 |
AGP > 100 mg/dL, n (%) | 37 (33.04) | 20 (19.42) | 0.024 1 |
AGP, adjusted PR (95% CI) | 1 | 0.52 (0.31; 0.85) | 0.009 3 |
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M. C. Lobo, L.; M. Schincaglia, R.; G. Peixoto, M.d.R.; C. M. Hadler, M.C., ENFAC Working Group. Multiple Micronutrient Powder Reduces Vitamin E Deficiency in Brazilian Children: A Pragmatic, Controlled Clinical Trial. Nutrients 2019, 11, 2730. https://doi.org/10.3390/nu11112730
M. C. Lobo L, M. Schincaglia R, G. Peixoto MdR, C. M. Hadler MC ENFAC Working Group. Multiple Micronutrient Powder Reduces Vitamin E Deficiency in Brazilian Children: A Pragmatic, Controlled Clinical Trial. Nutrients. 2019; 11(11):2730. https://doi.org/10.3390/nu11112730
Chicago/Turabian StyleM. C. Lobo, Lina, Raquel M. Schincaglia, Maria do Rosário G. Peixoto, and Maria Claret C. M. Hadler ENFAC Working Group. 2019. "Multiple Micronutrient Powder Reduces Vitamin E Deficiency in Brazilian Children: A Pragmatic, Controlled Clinical Trial" Nutrients 11, no. 11: 2730. https://doi.org/10.3390/nu11112730