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Review

Spatial Transcriptomics in Human Cardiac Tissue

by
Quynh Nguyen
1,2,3,
Lin Wei Tung
2,4,
Bruce Lin
2,4,
Raam Sivakumar
3,5,
Funda Sar
6,
Gurpreet Singhera
3,7,
Ying Wang
3,8,
Jeremy Parker
2,3,9,
Stephane Le Bihan
6,
Amrit Singh
3,5,
Fabio M.V. Rossi
2,4,
Colin Collins
6,10,
Jamil Bashir
1,11 and
Zachary Laksman
2,3,9,11,*
1
Division of Cardiac Surgery, Department of Surgery, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
2
School of Biomedical Engineering, University of British Columbia, Vancouver, BC V6T 2B9, Canada
3
Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC V6Z 1Y6, Canada
4
Department of Medical Genetics, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
5
Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
6
Vancouver Prostate Centre, Vancouver, BC V6H 3Z6, Canada
7
Department of Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
8
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
9
Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
10
Department of Urologic Sciences, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
11
St. Paul’s Hospital, Vancouver, BC V6Z 1Y6, Canada
 
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*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2025, 26(3), 995; https://doi.org/10.3390/ijms26030995
Submission received: 28 December 2024 / Revised: 21 January 2025 / Accepted: 23 January 2025 / Published: 24 January 2025
(This article belongs to the Special Issue New Insights in Translational Bioinformatics: Second Edition)
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Abstract

Spatial transcriptomics has transformed our understanding of gene expression by preserving the spatial context within tissues. This review focuses on the application of spatial transcriptomics in human cardiac tissues, exploring current technologies with a focus on commercially available platforms. We also highlight key studies utilizing spatial transcriptomics to investigate cardiac development, electro-anatomy, immunology, and ischemic heart disease. These studies demonstrate how spatial transcriptomics can be used in conjunction with other omics technologies to provide a more comprehensive picture of human health and disease. Despite its transformative potential, spatial transcriptomics comes with several challenges that limit its widespread adoption and broader application. By addressing these limitations and fostering interdisciplinary collaboration, spatial transcriptomics has the potential to become an essential tool in cardiovascular research. We hope this review serves as a practical guide for researchers interested in adopting spatial transcriptomics, particularly those with limited prior experience, by providing insights into current technologies, applications, and considerations for successful implementation.
Keywords: spatial transcriptomics; cardiovascular diseases; Visium; STomics; CurioSeeker; Xenium; GeoMX; CosMX; Molecular Cartography; MERSCOPE spatial transcriptomics; cardiovascular diseases; Visium; STomics; CurioSeeker; Xenium; GeoMX; CosMX; Molecular Cartography; MERSCOPE

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MDPI and ACS Style

Nguyen, Q.; Tung, L.W.; Lin, B.; Sivakumar, R.; Sar, F.; Singhera, G.; Wang, Y.; Parker, J.; Le Bihan, S.; Singh, A.; et al. Spatial Transcriptomics in Human Cardiac Tissue. Int. J. Mol. Sci. 2025, 26, 995. https://doi.org/10.3390/ijms26030995

AMA Style

Nguyen Q, Tung LW, Lin B, Sivakumar R, Sar F, Singhera G, Wang Y, Parker J, Le Bihan S, Singh A, et al. Spatial Transcriptomics in Human Cardiac Tissue. International Journal of Molecular Sciences. 2025; 26(3):995. https://doi.org/10.3390/ijms26030995

Chicago/Turabian Style

Nguyen, Quynh, Lin Wei Tung, Bruce Lin, Raam Sivakumar, Funda Sar, Gurpreet Singhera, Ying Wang, Jeremy Parker, Stephane Le Bihan, Amrit Singh, and et al. 2025. "Spatial Transcriptomics in Human Cardiac Tissue" International Journal of Molecular Sciences 26, no. 3: 995. https://doi.org/10.3390/ijms26030995

APA Style

Nguyen, Q., Tung, L. W., Lin, B., Sivakumar, R., Sar, F., Singhera, G., Wang, Y., Parker, J., Le Bihan, S., Singh, A., M.V. Rossi, F., Collins, C., Bashir, J., & Laksman, Z. (2025). Spatial Transcriptomics in Human Cardiac Tissue. International Journal of Molecular Sciences, 26(3), 995. https://doi.org/10.3390/ijms26030995

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