Treadmill Exercise Prevents Cognitive Impairments in Adolescent Intermittent Ethanol Rats by Reducing the Excessive Activation of Microglia Cell in the Hippocampus
Abstract
:1. Introduction
2. Results
2.1. Treadmill Exercise Prevented AIE-Induced Decline in Spatial Learning and Memory in Young Adult Rats
2.2. Treadmill Exercise Reversed AIE-Induced Inflammation in the Hippocampus of Young Adult Rats
2.3. Treadmill Exercise Decreased AIE-Induced Excessive Activation of Microglia in the Hippocampus of Young Adult Rats
2.4. Effects of Treadmill Exercise on the Protein Levels of CB1R, CB2R and MAGL in the Hippocampus of Young Adult Rats
3. Discussion
4. Materials and Methods
4.1. Animals
4.2. Adolescent Intermittent Ethanol (AIE) Paradigm
4.3. Treadmill Exercise Protocol
4.4. Eight-Arm Radial Maze Test
4.5. Enzyme-Linked Immunosorbent Assay (ELISA)
4.6. Immunofluorescent Staining
4.7. Western Blots
4.8. Statistical Analysis
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Guo, Y.; Yan, M.; Li, L.; Zhao, L.; Li, Y. Treadmill Exercise Prevents Cognitive Impairments in Adolescent Intermittent Ethanol Rats by Reducing the Excessive Activation of Microglia Cell in the Hippocampus. Int. J. Mol. Sci. 2022, 23, 14701. https://doi.org/10.3390/ijms232314701
Guo Y, Yan M, Li L, Zhao L, Li Y. Treadmill Exercise Prevents Cognitive Impairments in Adolescent Intermittent Ethanol Rats by Reducing the Excessive Activation of Microglia Cell in the Hippocampus. International Journal of Molecular Sciences. 2022; 23(23):14701. https://doi.org/10.3390/ijms232314701
Chicago/Turabian StyleGuo, Yanxia, Min Yan, Li Li, Li Zhao, and Yan Li. 2022. "Treadmill Exercise Prevents Cognitive Impairments in Adolescent Intermittent Ethanol Rats by Reducing the Excessive Activation of Microglia Cell in the Hippocampus" International Journal of Molecular Sciences 23, no. 23: 14701. https://doi.org/10.3390/ijms232314701