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Volume 23
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10.3390/ijms23063040
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Article

On the Efficacy of ZnO Nanostructures against SARS-CoV-2

by
Maria Chiara Sportelli
1,†,
Margherita Izzi
1,†,
Daniela Loconsole
2,
Anna Sallustio
3,
Rosaria Anna Picca
1,
Roberto Felici
4,
Maria Chironna
2,* and
Nicola Cioffi
1,*
1
Chemistry Department, University of Bari Aldo Moro, Via Orabona, 4, 70126 Bari, Italy
2
Department of Biomedical Sciences and Human Oncology-Hygiene Section, University of Bari Aldo Moro, Piazza Giulio Cesare, 11, 70124 Bari, Italy
3
Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari, Piazza G. Cesare, 11, 70124 Bari, Italy
4
CNR-SPIN, Area Della Ricerca di Tor Vergata, Via del Fosso del Cavaliere, 100, 00133 Rome, Italy
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2022, 23(6), 3040; https://doi.org/10.3390/ijms23063040
Submission received: 17 February 2022 / Revised: 8 March 2022 / Accepted: 9 March 2022 / Published: 11 March 2022
(This article belongs to the Special Issue Recent Advances in Nanotechnology for Antibacterials and Antimicrobials)
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Abstract

In 2019, the new coronavirus disease (COVID-19), related to the severe acute respiratory syndrome coronavirus (SARS-CoV-2), started spreading around the word, giving rise to the world pandemic we are still facing. Since then, many strategies for the prevention and control of COVID-19 have been studied and implemented. In addition to pharmacological treatments and vaccines, it is mandatory to ensure the cleaning and disinfection of the skin and inanimate surfaces, especially in those contexts where the contagion could spread quickly, such as hospitals and clinical laboratories, schools, transport, and public places in general. Here, we report the efficacy of ZnO nanoparticles (ZnONPs) against SARS-CoV-2. NPs were produced using an ecofriendly method and fully characterized; their antiviral activity was tested in vitro against SARS-CoV-2, showing a decrease in viral load between 70% and 90%, as a function of the material’s composition. Application of these nano-antimicrobials as coatings for commonly touched surfaces is envisaged.
Keywords: zinc oxide; nano-antimicrobials; green synthesis; antiviral; COVID-19; nucleocapsid protein; nasopharyngeal swab; SARS-CoV-2 zinc oxide; nano-antimicrobials; green synthesis; antiviral; COVID-19; nucleocapsid protein; nasopharyngeal swab; SARS-CoV-2

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MDPI and ACS Style

Sportelli, M.C.; Izzi, M.; Loconsole, D.; Sallustio, A.; Picca, R.A.; Felici, R.; Chironna, M.; Cioffi, N. On the Efficacy of ZnO Nanostructures against SARS-CoV-2. Int. J. Mol. Sci. 2022, 23, 3040. https://doi.org/10.3390/ijms23063040

AMA Style

Sportelli MC, Izzi M, Loconsole D, Sallustio A, Picca RA, Felici R, Chironna M, Cioffi N. On the Efficacy of ZnO Nanostructures against SARS-CoV-2. International Journal of Molecular Sciences. 2022; 23(6):3040. https://doi.org/10.3390/ijms23063040

Chicago/Turabian Style

Sportelli, Maria Chiara, Margherita Izzi, Daniela Loconsole, Anna Sallustio, Rosaria Anna Picca, Roberto Felici, Maria Chironna, and Nicola Cioffi. 2022. "On the Efficacy of ZnO Nanostructures against SARS-CoV-2" International Journal of Molecular Sciences 23, no. 6: 3040. https://doi.org/10.3390/ijms23063040

APA Style

Sportelli, M. C., Izzi, M., Loconsole, D., Sallustio, A., Picca, R. A., Felici, R., Chironna, M., & Cioffi, N. (2022). On the Efficacy of ZnO Nanostructures against SARS-CoV-2. International Journal of Molecular Sciences, 23(6), 3040. https://doi.org/10.3390/ijms23063040

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