Immunopathogenesis of Malaria
A special issue of Tropical Medicine and Infectious Disease (ISSN 2414-6366). This special issue belongs to the section "Vector-Borne Diseases".
Deadline for manuscript submissions: closed (10 November 2023) | Viewed by 412
Special Issue Editor
Special Issue Information
Dear Colleagues,
This Special Issue will focus on innate immunity to malaria infection and its immunopathology. Malaria remains a public health issue, especially in endemic regions, with more than 200 million cases and about half a million deaths annually. Children and pregnant women are more vulnerable to being infected with malaria. During malaria infection, Plasmodium-specific pathogen-associated molecular patterns are recognized by the host immune system; this is followed by the activation of several intracellular signaling pathways, such as the inflammasome, nuclear factor kappa b, and type I interferon pathways. These pathways play important key roles in malaria immunology and in the control of parasite replication, as well as its ultimate elimination by the host. However, the parasite may evade host immune responses, including the induction of negative regulators to inhibit and escape host immune responses and initiate pathology. Our understanding of these mechanisms remains very limited; therefore, malaria continues to be a major public health issue. In addition, the parasite can develop resistance to antimalarial drugs and an efficient vaccine is still needed. To broaden our molecular mechanistic understanding of innate immunity to malaria, and its immunopathogenesis, we need more basic research to understand why stubborn malaria parasites still circulate inside the host, leading to severe cases. A better understanding of these parasite–host interactions at the molecular levels will aid the design of better treatments and preventive strategies.
Dr. Demba Sarr
Guest Editor
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Keywords
- malaria
- innate immunity
- immunopathogenesis
- Plasmodium
- molecular mechanisms
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