Leishmaniasis in Europe and the Mediterranean Region

Special Issue Editors


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Guest Editor
1. National Reference Centre for Tropical Diseases, Infectious Diseases Department, WHO Collaborating Centre for Clinical Management of Leishmaniasis, Ramón y Cajal University Hospital, IRYCIS, Madrid, Spain
2. CIBERINFEC, Instituto de Salud Carlos III, Madrid, Spain
Interests: leishmaniasis; neglected tropical diseases; imported infectious diseases; migrants’ health; malaria; immunosupression

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Guest Editor
1. Infectious Diseases Section, Internal Medicine Department, University Hospital of Fuenlabrada, Madrid, Spain
2. CIBERINFEC, Instituto de Salud Carlos III, Madrid, Spain
Interests: leishmaniasis; neglected tropical diseases; malaria; immunosupression; human immunodeficiency virus (HIV)

Special Issue Information

Dear Colleagues,

Leishmaniasis, a vector-borne parasitic disease caused by protozoa of the genus Leishmania, remains a significant global health challenge, particularly in endemic regions such as South America, Africa, and the Indian subcontinent. However, the epidemiology of leishmaniasis in Europe and the Mediterranean region has attracted mounting attention due to several factors. These include the under-reporting of cases, non-HIV immunosuppression, and the potential impact of climate change on the distribution of vector species.

Although considered a neglected disease, leishmaniasis is a growing public health problem in Europe. Under-reporting remains a major problem, hampering accurate assessment of the disease burden. In addition, the increasing prevalence of visceral leishmaniasis (VL) in immunosuppressed patients—such as those receiving immunomodulatory therapies—highlights the need for better diagnostic and management strategies. Recent research efforts have focused on identifying reliable immunological markers in the cure of VL, which could improve patient monitoring and treatment outcomes.

Climate change is another pressing factor, as rising temperatures may facilitate the northward expansion of Phlebotomus sandfly vectors, increasing the risk of autochthonous transmission in previously non-endemic areas of northern Europe. In addition, imported cases due to travel and migration highlight the need for increased awareness and preparedness among healthcare professionals.

Addressing these challenges requires a One Health approach that integrates human, animal, and environmental health perspectives. There is an urgent need for improving the training of health workers, increasing public awareness, and developing novel therapeutic strategies. This Special Issue of Tropical Medicine and Infectious Diseases seeks high quality papers on epidemiological trends, clinical management, novel diagnostic and therapeutic approaches, and policy recommendations for the control of leishmaniasis in Europe and the Mediterranean. We invite researchers and clinicians to submit their work contributing to the advancement of knowledge and providing solutions for this evolving public health threat.

Dr. Begoña Monge-Maillo
Dr. Juan Víctor San Martín-López
Guest Editors

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Keywords

  • visceral leishmaniasis
  • cutaneous leishmaniasis
  • mucocutaneous leishmaniasis
  • Leishmania infantum
  • Leishmania major
  • Leishmania tropica
  • imported leishmaniasis
  • immunosupression
  • one health
  • climate change
  • biomarkers

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Published Papers (1 paper)

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Research

18 pages, 665 KB  
Communication
Agreement Document for the Study of Leishmaniasis from a One Health Approach in Spain
by Joaquina Martín-Sánchez, Jose M. Requena, Montserrat Gállego, Maribel Jiménez, Ricardo Molina, Paul Nguewa, Francisco Morillas-Márquez, José M. Pérez-Victoria, Begoña Monge-Maillo, Manuel Morales-Yuste and Clotilde Marín
Trop. Med. Infect. Dis. 2025, 10(9), 269; https://doi.org/10.3390/tropicalmed10090269 - 18 Sep 2025
Viewed by 635
Abstract
Background: Leishmaniasis, a vector-borne disease caused by the parasite Leishmania, is a public health concern in Europe. Although Spain is an endemic country, it lacks a national surveillance network. To address this, the creation of a research and surveillance network is [...] Read more.
Background: Leishmaniasis, a vector-borne disease caused by the parasite Leishmania, is a public health concern in Europe. Although Spain is an endemic country, it lacks a national surveillance network. To address this, the creation of a research and surveillance network is proposed, which would integrate data from various fields and enhance control and public health strategies. Objectives: The first objective is to gather epidemiological data on vectors, reservoirs, and transmission rates in Spain, with a particular focus on the role of dogs and wildlife as primary reservoirs. The plan includes establishing forums, databases, and specialised training programmes. The second objective is to improve case surveillance and reporting by establishing a comprehensive national registry. Implementing molecular diagnostics and bioinformatics tools will aid analysis of retrospective data and tracking of disease evolution. The third objective is to develop a standardised method for the molecular characterisation of Leishmania, using techniques such as PCR and genomic sequencing to detect virulence and resistance patterns. Key actions include collecting isolates, sharing analytical tools and providing genomic training. The fourth objective is to identify new therapeutic targets in response to toxicity and resistance to current treatments by studying specific enzymes (FeSOD, HDAC), metabolic pathways, and natural products. Ultimately, establishing the Leishmaniasis Surveillance Network will support a “One Health” approach and promote interdisciplinary collaboration towards a national control plan. Methods: We created the Working Group on Leishmaniasis funded by the Spanish Society of Tropical Medicine and International Health as a leishmaniasis forum for meetings and discussions on weaknesses and gaps we find in the knowledge and management of the infection based on the background of each academic and healthcare research group. Expected Impact: This study will promote the articulation of a Leishmaniasis Surveillance Network aiming to bring together the main stakeholders in the research and management of leishmaniasis in Spain. Full article
(This article belongs to the Special Issue Leishmaniasis in Europe and the Mediterranean Region)
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