Special Issue "Novel Therapeutic Modalities for Multiple Sclerosis"

A special issue of Sci (ISSN 2413-4155).

Deadline for manuscript submissions: closed (15 May 2021).

Special Issue Editors

Prof. Dr. Azzam A. Maghazachi
E-Mail Website
Guest Editor
Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah 27272, UAE
Interests: cancer; oncology; multiple sclerosis; autoimmune diseases; immunology; chemokines; hematology; drug mechanisms of action (MOA)
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Jennifer Hundt
E-Mail Website
Guest Editor
LIED - Lübecker Institut für Experimentelle Dermatologie, Universität zu Lübeck, 23562 Lübeck, Germany
Interests: dermatology; Experimental Dermatology; hair; human epithelial progenitor cell

Special Issue Information

Dear Colleagues,

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) that affects several million patients worldwide. Several drugs have been developed to treat this disease, which are mainly directed toward patients with relapsing–remitting MS. However, these drugs are pleotropic, and their mechanisms of action (MOA) vary between switching the immune system towards anti-inflammatory type 2 response, or preventing autoreactive T cells from extravasation into the CNS. Immunomodulatory drugs such as Avonex (interferon β-1), Copaxone (glatiramer acetate), Gilenya (fingolimod), Tecfidera (dimethyl fumarate), Novantrone (mitoxantrone), and Aubagio (teriflunomide), among others, have been used as disease-modifying therapy. Further, monoclonal antibodies which target specific molecules have also been used. Among these are Tysabri (Natalizumab), Lemtrada (alemtuzumab), and Ocrevus (ocrelizumab). Recent work has showen that drugs used to treat cancer patients such as Rituxan (rituximab), Actemra (Tocilizumab or atlizumab), and Avastin (bevacizumab) can also be used to treat MS patients.

However, all of the above-mentioned drugs do not cure MS and can only improve the quality of life of MS patients by reducing the periods of relapse and increasing the periods of remission. Before translating the effects of these drugs into actual treatment, they must be examined for their ability to reduce clinical scores in the established mouse model of MS, namely experimental autoimmune encephalomyelitis (EAE). Therefore, this model is considered an important one for investigating the effects and MOA of any new drug that could eventually be used to treat patients.

This Research Topic will focus on new therapeutic modalities to treat MS patients or EAE mice that aim to modulate the immune system in these pathologies. In addition, the Research Topic will also discuss new information or novel MOA for the drugs already used from an immunological perspective. Emphasis will be directed towards drugs and monoclonal antibodies which are not only important as prophylactic and therapeutic tools, but also as tools to prevent developing the disease, particularly in those patients who will be stratified based on genetic data for a more personalized approach to treatment. We welcome the submission of Original Research, Review and Mini-Review articles covering the following topics:

  • Development of new drugs and monoclonal antibodies that target the immune system with the aim of treating and/or preventing MS in humans or in mouse model;
  • Investigating the MOA of novel drugs or monoclonal antibodies from an immunological perspective;
  • Exploring the roles of B cells, T cells, dendritic cells, and natural killer cells in MS disease and how these populations can be modulated therapeutically in MS and EAE;
  • Investigating the pharmacokinetics and pharmacogenomics of novel drugs or monoclonal antibodies;
  • Novel understanding for already used drugs to treat patients or animals affected by the disease.

Prof. Dr. Azzam A. Maghazachi
Prof. Dr. Jennifer Hundt
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Multiple sclerosis
  • Experimental autoimmune encephalomyelitis
  • Drugs
  • Therapy
  • Innate immunity
  • Adaptive immunity
  • Bioinformatics
  • Epigenetics
  • Monoclonal antibodies
  • Mechanisms of action.

Published Papers (1 paper)

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Role of Peripheral Immune Cells in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis
Sci 2021, 3(1), 12; https://doi.org/10.3390/sci3010012 - 01 Feb 2021
Cited by 2 | Viewed by 2048
Multiple sclerosis (MS) is a chronic autoimmune disease that affects the myelination of the neurons present in the central nervous system (CNS). The exact etiology of MS development is unclear, but various environmental and genetic factors might play a role in initiating the [...] Read more.
Multiple sclerosis (MS) is a chronic autoimmune disease that affects the myelination of the neurons present in the central nervous system (CNS). The exact etiology of MS development is unclear, but various environmental and genetic factors might play a role in initiating the disease. Experimental autoimmune encephalomyelitis (EAE) is a mouse model that is used to study the pathophysiology of MS disease as well as the effects of possible therapeutic agents. In addition, autoreactive immune cells trigger an inflammatory process upon the recognition of CNS antigens, which leads to destruction of the neurons. These include innate immune cells such as macrophages, dendritic cells, and natural killer cells. Additionally, the activation and extravasation of adaptive immune cells such as CD4+ T cells into the CNS may lead to further exacerbation of the disease. However, many studies revealed that immune cells could have either a protective or pathological role in MS. In this review, we highlight the roles of innate and adaptive immune cellular and soluble players that contribute to the pathogenesis of MS and EAE, which may be used as potential targets for therapy. Full article
(This article belongs to the Special Issue Novel Therapeutic Modalities for Multiple Sclerosis)
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