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Reprod. Med.
Special Issues
Pathology and Diagnosis of Gynecologic Diseases, 3rd Edition
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Pathology and Diagnosis of Gynecologic Diseases, 3rd Edition

A special issue of Reproductive Medicine (ISSN 2673-3897).

Deadline for manuscript submissions: 31 December 2025 | Viewed by 1246

Special Issue Editors

Dr. Cinzia Giacometti

E-Mail Website
Guest Editor
Pathology Unit, Pederzoli Hospital, 37019 Peschiera del Garda, Italy
Interests: feto-placental pathology; gynecologic pathology; breast pathology
Special Issues, Collections and Topics in MDPI journals
Dr. Mariateresa Mirandola

E-Mail
Guest Editor Assistant
Gynecology Unit, Pederzoli Hospital, 37019 Peschiera del Garda, Verona, Italy
Interests: gynecological oncology

Special Issue Information

Dear Colleagues,

When approaching diagnostic pathology in gynecologic diseases, many different scenarios can be encountered: benign lesions mimick malignant ones, and vice versa; hormonal effects (either menstrual, pregnancy, or therapy-related) alter normal histology and create artifacts; systemic diseases (such as diabetes and connective tissue diseases) influence the hormonal status and affect placentation and gestation; genetic imbalance (BRCA, p53, mismatch repair protein deficiency) can cause breast, endometrial, and ovary cancer. This female “cosmos”, in which so much is interconnected and happens as a result of something else, is complex, and diagnostic challenges, tough differential diagnosis, and pitfalls are routinely encountered.

Against this background, this Special Issue focuses on different, and innovative approaches to the diagnosis, use, and application of alternative/ancillary techniques (immunohistochemistry, in situ hybridization, and molecular biology) and methodological perspectives.

We warmly invite experts to contribute the following:

  • Original research articles, also on animal models;
  • Review articles/mini reviews;
  • Short communications/expert points of view;
  • Interesting images on rare entities.

You may choose our Joint Special Issue in Diagnostics.

Dr. Cinzia Giacometti
Guest Editor

Dr. Mariateresa Mirandola
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Reproductive Medicine is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gynecologic pathology
  • breast pathology
  • placental pathology
  • diagnostic pitfalls
  • differential diagnosis
  • molecular biology
  • immunohistochemistry
  • in situ hybridization

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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12 pages, 459 KB  
Article
The Role of the Setting in Controlling Anxiety and Pain During Outpatient Operative Hysteroscopy: The Experience of a Hysteroscopy Unit in North Italy
by Alessandro Messina, Alessio Massaro, Eleonora Dalmasso, Ilaria Giovannini, Giovanni Lipari, Paolo Alessi, Tiziana Bruno, Sofia Vegro, Daniela Caronia, Federica Savasta, Valentino Remorgida, Alessandro Libretti and Bianca Masturzo
Reprod. Med. 2025, 6(3), 25; https://doi.org/10.3390/reprodmed6030025 - 12 Sep 2025
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Abstract
Background/Objectives: Outpatient operative hysteroscopy is a cornerstone in the management of intrauterine pathologies within reproductive medicine. However, procedural pain and anxiety remain key barriers leading to failed procedures and referrals for surgery under general anesthesia. This study aimed to assess whether a comfort-enhanced [...] Read more.
Background/Objectives: Outpatient operative hysteroscopy is a cornerstone in the management of intrauterine pathologies within reproductive medicine. However, procedural pain and anxiety remain key barriers leading to failed procedures and referrals for surgery under general anesthesia. This study aimed to assess whether a comfort-enhanced procedural environment could reduce perceived pain and increase procedural success rates. Methods: Analysis of 970 consecutive patients who underwent outpatient operative hysteroscopy at the Hysteroscopy Unit of “Degli Infermi” Hospital (Biella, Italy): 470 in 2023 under standard conditions, 500 in 2024 with an enhanced setting. Surgical technique, analgesic/sedation policies and operators were unchanged. The primary outcome was referral to the OR for completion of the procedure. Secondary outcomes included patient-reported pain assessed by Visual Analog Scale (VAS) in a consecutive subsample. Differences between years were evaluated with appropriate parametric/non-parametric tests. Results: Implementation of the enhanced environment was associated with a lower OR referral rate in 2023 versus 2024. Post hoc power for this comparison was approximately 60%. Mean VAS scores also decreased in 2024, with post hoc power >99%. No adverse events were recorded. Conclusions: Environmental and interpersonal modifications were associated with meaningful decline in reported pain and OR referrals. Prospective studies incorporating systematic case-mix and validated anxiety measures are warranted to confirm these results. Full article
(This article belongs to the Special Issue Pathology and Diagnosis of Gynecologic Diseases, 3rd Edition)
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14 pages, 588 KB  
Systematic Review
Exploring the Role of Anti-Adhesion Gel in Outpatient Operative Hysteroscopy
by Alessandro Messina, Safae El Motarajji, Ilaria Giovannini, Alessandro Libretti, Federica Savasta, Valentino Remorgida, Livio Leo and Bianca Masturzo
Reprod. Med. 2025, 6(3), 22; https://doi.org/10.3390/reprodmed6030022 - 28 Aug 2025
Viewed by 537
Abstract
Background: Outpatient operative hysteroscopy is a minimally invasive procedure widely used for the diagnosis and treatment of intrauterine pathologies, including intrauterine adhesions (IUAs), which significantly affect fertility. Despite its therapeutic potential, the procedure itself may predispose patients to de novo adhesion formation. This [...] Read more.
Background: Outpatient operative hysteroscopy is a minimally invasive procedure widely used for the diagnosis and treatment of intrauterine pathologies, including intrauterine adhesions (IUAs), which significantly affect fertility. Despite its therapeutic potential, the procedure itself may predispose patients to de novo adhesion formation. This review evaluates the effectiveness of anti-adhesion gels, particularly hyaluronic-acid-based formulations, in preventing IUAs and improving reproductive outcomes after outpatient operative hysteroscopy. Materials and Methods: A systematic search was performed in PubMed, CINAHL, Embase, and Web of Science for studies published between January 2020 and May 2025. Inclusion and exclusion criteria were defined using PICO guidelines. Relevant studies were screened and selected by two independent reviewers. Results: Anti-adhesion gels, especially hyaluronic acid and its derivatives, were associated with a lower recurrence of IUAs and improved reproductive outcomes. Combination therapies, such as hyaluronic acid gel with intrauterine devices (IUDs), showed better efficacy than monotherapy. Several studies also reported increased endometrial thickness, higher implantation rates, and improved pregnancy outcomes, although live birth rates remained inconsistent. Conclusions: Hyaluronic-acid-based anti-adhesion gels appear effective in reducing postoperative adhesion formation and enhancing reproductive outcomes in outpatient hysteroscopy. The best results are seen with multimodal preventive strategies. However, heterogeneity across studies highlights the need for standardized, prospective, randomized controlled trials to establish optimal clinical use. Full article
(This article belongs to the Special Issue Pathology and Diagnosis of Gynecologic Diseases, 3rd Edition)
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