Advancements in Clinical Applications of Immune Checkpoint Inhibitors

A special issue of Reports (ISSN 2571-841X).

Deadline for manuscript submissions: closed (30 November 2024) | Viewed by 993

Special Issue Editors


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Guest Editor
Department of Respiratory Medicine, Sendai City Hospital, Sendai 982-8502, Miyagi, Japan
Interests: HIV; infection
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Guest Editor
Department of Obstetrics and Gynecology, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
Interests: epigenetics; DNA demethylation; ubiquitin ligase; gynecologic oncology
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Special Issue Information

Dear Colleagues,

It has been more than ten years since the clinical use of immune checkpoint inhibitors (ICIs), and we are still trying to utilize them more effectively.

This Special Issue aims to compile a collection of articles that highlight the latest advancements in the clinical research of immune checkpoint inhibitors, including but not limited to the following:

  • Clinical trials evaluating the efficacy and safety of immune checkpoint inhibitors in different cancer types.
  • Combination therapies involving immune checkpoint inhibitors.
  • Management of adverse events related to immune checkpoint inhibitors.
  • Biomarkers related to immune checkpoint inhibitor therapy.
  • Timing to stop ICIs.

We invite the submission of original research articles, reviews, and case reports in this field.

Dr. Yugo Ashino
Dr. Ichiro Onoyama
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • immune checkpoint inhibitors
  • immune checkpoints
  • immunotherapy
  • combination therapies
  • immune-related adverse events (irAEs) and treatment-related adverse events (TRAEs)

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Published Papers (1 paper)

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6 pages, 1637 KiB  
Case Report
Pembrolizumab Induced Recall Dermatitis Occurring 5 Years After Radiotherapy
by Caroline J. Cushman, Fuad Abaleka, Andrew F. Ibrahim, Kiran Yalamanchili, Seshadri Thirumala and Donald Quick
Reports 2024, 7(4), 91; https://doi.org/10.3390/reports7040091 - 4 Nov 2024
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Abstract
Background and Clinical Significance: Radiation recall dermatitis (RRD) following immune checkpoint inhibitor (ICI) therapy has been infrequently reported. Case Presentation: We present a 47-year-old female patient who developed RRD of the breast following three doses of pembrolizumab administered as an adjuvant treatment post-nephrectomy [...] Read more.
Background and Clinical Significance: Radiation recall dermatitis (RRD) following immune checkpoint inhibitor (ICI) therapy has been infrequently reported. Case Presentation: We present a 47-year-old female patient who developed RRD of the breast following three doses of pembrolizumab administered as an adjuvant treatment post-nephrectomy for Stage III renal cell carcinoma (RCC). Notably, the affected breast had previously undergone external beam radiotherapy 247 weeks earlier for Stage IA invasive ductal carcinoma. She had received no prior chemotherapy at any point. RRD manifested as breast induration, erythema, and peau d’orange, and contraction of breast volume was noted following three cycles of pembrolizumab on week 17 (400 mg dose every 6 weeks). The dermatitis responded rapidly to systemic corticosteroids and no treatment interruption was needed. Conclusions: To date, this is the longest reported interval from completion of radiotherapy to RRD. A literature search underscores the variability in presentation and management of ICI-associated RRD. Full article
(This article belongs to the Special Issue Advancements in Clinical Applications of Immune Checkpoint Inhibitors)
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