Advanced Diagnostic and Treatment Approach in Pediatric Hepatology
A special issue of Pediatric Reports (ISSN 2036-7503).
Deadline for manuscript submissions: 30 September 2026 | Viewed by 1020
Special Issue Editor
2. 2nd Pediatric Clinic, Emergency Clinical Hospital for Children, 400177 Cluj-Napoca, Romania
Interests: pediatrics; hepatology; gastroenterology; nutrition; metabolic diseases; immunology; non-invasive evaluation methods; e-learning; social pediatrics
Special Issue Information
Dear Colleagues,
Contemporary pediatric hepatology has reached a crucial turning point, driven by significant advances in diagnostic tools and treatment options. This Special Issue covers the full range of pediatric liver diseases, reflecting the changing practice of clinical care.
Advanced diagnostics have revolutionized clinical management across various disease entities. Non-invasive imaging techniques, including ultrasound and magnetic resonance elastography, now enable accurate assessment of fibrosis without procedural risk. Next-generation sequencing has transformed the identification of inherited cholestatic liver diseases, enabling rapid genetic diagnosis. Advanced serological and immunologic profiling has changed disease stratification in autoimmune hepatitis, allowing for mechanistically informed treatment choices. A better understanding of the gut–liver axis clarifies the bidirectional relationship between inflammatory bowel disease and autoimmune hepatobiliary disorders.
The therapeutic paradigm has shifted toward mechanistically informed, disease-modifying treatments, improving the outcomes across pediatric hepatology. Bile acid transporter inhibitors have revolutionized the management of genetic cholestasis, potentially delaying or preventing the need for transplantation. In autoimmune hepatitis, novel immunosuppressive agents have expanded treatment options. Direct-acting antivirals continue to advance in pediatric viral hepatitis management, while a better understanding of gut–liver interactions informs integrated management of IBD-associated hepatobiliary disease.
Liver transplantation remains the definitive treatment for end-stage liver disease and certain metabolic disorders, with significantly improved outcomes. Modern strategies, including living donor transplantation, advanced immunosuppressive therapies, and improved long-term follow-up, have resulted in 20-year patient survival rates exceeding 95%.
This Special Issue aims to include contributions that focus on diagnostic innovation, therapeutic progress, and transplantation outcomes throughout the entire spectrum of pediatric liver disease. These articles showcase the field's development toward mechanistically driven, genotype-guided, and outcome-centered care, which aligns with current principles of pediatric hepatology practice. We believe this collection will become a key resource for clinicians, researchers, and trainees involved in pediatric liver disease management and will drive further progress in this quickly advancing field.
Dr. Tudor Lucian Pop
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pediatric Reports is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- pediatric hepatology
- autoimmune liver diseases
- genetic cholestasis
- chronic viral hepatitis
- acute liver failure
- rare diseases
- next-generation sequencing
- non-invasive imaging
- direct-acting antivirals
- bile acid transporter inhibitors
- disease-modifying therapy
- liver transplantation
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