Obesities

Background/Objectives: The high prevalence of obesity and obesity-associated diseases in the United States and worldwide places a tremendous burden on public health. Although lifestyle interventions, such as calorie-restricted diets and increased exercise, are generically recommended to individuals with overweight and obesity, it is well acknowledged that individual responses to the same lifestyle intervention vary significantly, underscoring the importance of individualized or precision nutrition-based approaches in obesity management. Methods: In a recent randomized, parallel-arm pilot study, manuka honey (21 g) was given daily to overweight and obese participants aged 40–75 years for four weeks. The levels of plasma interleukin (IL)-6 at the baseline and after honey treatment were measured. The 14 female participants were stratified into responder (R) and non-responder (NR) groups, based on their circulating IL-6 level changes. Plasma and fecal samples from the R and NR groups were subjected to untargeted metabolomics analysis and 16S rRNA analysis, respectively. Results: Among the female participants with overweight and obesity, 50% had reduced plasma levels of IL-6 after honey intake, and other 50% showed no such responses. Untargeted metabolomics analysis demonstrated that 22 metabolites markedly increased and eight decreased in the R group, relative to the NR group. A decrease in circulating glutamic acid could potentially predict the responsiveness to honey intake. 16S rRNA analysis showed that 23 and 14 genera were uniquely enriched in the R and NR groups, respectively. Enriched Bacteroides and Akkermansia in the R group are capable of metabolizing glutamic acid and thus may contribute to the decreased level of circulating glutamic acid. Conclusions: In this pilot study, participants with overweight and obesity showed different responses to honey intake. Circulating glutamic acid may have the potential to predict the responsiveness of patients to honey and provide guidance for precision nutrition-based dietary intervention.

Obesity is a global health concern affecting all income levels, with body mass index (BMI) traditionally used for diagnosis. However, BMI does not accurately reflect body composition. Normal weight obesity (NWO) describes individuals with a normal BMI but elevated body fat percentage and has been associated with metabolic abnormalities and reduced physical fitness. This cross-sectional study included 384 adults aged 18–40 years with a BMI between 18.5 and 24.9 kg/m². Anthropometric measurements and body composition were assessed using an InBody H20 bioelectrical impedance device, and handgrip strength was measured with a Camry electronic dynamometer. NWO was defined as body fat percentage ≥20% in men and ≥30% in women. The overall prevalence of NWO was 77.3%. Although prevalence appeared higher in men than in women, this difference was not statistically significant after adjustment for multiple comparisons. Participants with NWO showed significantly higher body fat percentage, visceral fat index, hip circumference, and blood pressure compared with normal weight non-obese individuals after Holm–Bonferroni correction. Skeletal muscle mass was lower in the NWO group, although this difference did not remain statistically significant after adjustment. Multivariate logistic regression identified right-hand grip strength as an independent protective factor against NWO.

In our surgical center, we have observed a high occurrence of hiccups and rhinorrhea following bariatric surgery. This retrospective study aimed to assess the frequency of post-prandial hiccups and rhinorrhea following bariatric surgery and explore potential behavioral and clinical associations. The study was performed at Cannizzaro Hospital (Catania, Italy), an institution accredited by SICOB (Italian Society for Bariatric and Metabolic Surgery) as a national referral center. The cohort included bariatric patients who completed a preoperative psychological evaluation and adhered to a one-year post-surgical follow-up between October 2022 and November 2023. Data on eating behaviors, mental status and dietary habits were collected for each patient before surgery, while clinical records, including the recurrence of hiccups and rhinorrhea, were acquired at the following time points: baseline and 1, 3, 6 and 12 months post-surgery. Post-prandial hiccups and/or rhinorrhea were reported by 49.5% of patients at 1 month and persisted in 46.8% after 12 months. No significant associations were found between the symptoms and weight loss, BES score, or psychological traits, except for slight associations with smoking and carbonated beverage intake. In our cohort, the etiology of hiccups and rhinorrhea appears unrelated to behavioral or psychological factors and may instead reflect vagal hyper-responsiveness after gastric fundus resection.