Advances in Alzheimer’s Disease and Related Dementias

A special issue of NeuroSci (ISSN 2673-4087).

Deadline for manuscript submissions: closed (31 August 2022) | Viewed by 10529

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Special Issue Information

Dear Colleagues, 

Alzheimer’s disease and related dementias remain the leading cause of death and disability worldwide. However, the current beta-amyloid (Aβ) and tau-targeting therapies for Alzheimer’s disease failed in the clinical trials, and whether Aβ accumulation is the cause or consequence of Alzheimer’s disease is unclear. Major advances have been made by investigating novel mechanisms underlying neuroinflammation, neuronal death, synaptic dysfunction, cerebrovascular dysfunction etc., which contribute to the development of Alzheimer’s disease and related dementias. The role of risk factors including aging, cardiovascular diseases, and metabolic disorders are also attracting attention by researchers to investigate the novel mechanisms underlying the pathogenesis of Alzheimer’s disease and related dementias. The present Special Issue aims to include research in all the areas related to studies in Alzheimer’s disease and related dementias. We invite manuscripts in the form of original research, reviews, mini-reviews, and short communications investigating/commenting on the novel mechanisms of pathogenesis of Alzheimer’s disease and related dementias. 

Potential topics include, but are not limited to:

  • Beta-amyloid (Aβ) and tau pathology
  • Neuronal death and synaptic dysfunction
  • Neuroinflammation
  • Risk factors: Lifestyle, cardiovascular diseases, and metabolic disorders et al. in the contribution to Alzheimer's dementia and related dementias
  • Cerebrovascular dysfunction, blood–brain barrier leakage, cerebral blood flow dysregulation, neurovascular coupling, cerebrovascular remodeling et al. in Alzheimer's and related dementias
  • Immune system in the pathogenesis of Alzheimer's disease and related dementias
  • Novel therapies for the treatment of Alzheimer's disease and related dementias.

Dr. Shaoxun Wang
Guest Editor

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Published Papers (1 paper)

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Review

22 pages, 2431 KiB  
Review
Does Dementia Have a Microbial Cause?
by Remi L. Landry and Monica E. Embers
NeuroSci 2022, 3(2), 262-283; https://doi.org/10.3390/neurosci3020019 - 17 May 2022
Cited by 6 | Viewed by 10061
Abstract
The potential contribution of pathogenic microbes to dementia-inducing disease is a subject of considerable importance. Alzheimer’s disease (AD) is a neurocognitive disease that slowly destroys brain function, leading to cognitive decline and behavioral and psychiatric disorders. The histopathology of AD is associated with [...] Read more.
The potential contribution of pathogenic microbes to dementia-inducing disease is a subject of considerable importance. Alzheimer’s disease (AD) is a neurocognitive disease that slowly destroys brain function, leading to cognitive decline and behavioral and psychiatric disorders. The histopathology of AD is associated with neuronal loss and progressive synaptic dysfunction, accompanied by the deposition of amyloid-β (Aβ) peptide in the form of parenchymal plaques and abnormal aggregated tau protein in the form of neurofibrillary tangles. Observational, epidemiological, experimental, and pathological studies have generated evidence for the complexity and possible polymicrobial causality in dementia-inducing diseases. The AD pathogen hypothesis states that pathogens and microbes act as triggers, interacting with genetic factors to initiate the accumulation of Aβ, hyperphosphorylated tau protein (p-tau), and inflammation in the brain. Evidence indicates that Borrelia sp., HSV-1, VZV (HHV-2), HHV-6/7, oral pathogens, Chlamydophila pneumoniae, and Candida albicans can infect the central nervous system (CNS), evade the immune system, and consequently prevail in the AD brain. Researchers have made significant progress in understanding the multifactorial and overlapping factors that are thought to take part in the etiopathogenesis of dementia; however, the cause of AD remains unclear. Full article
(This article belongs to the Special Issue Advances in Alzheimer’s Disease and Related Dementias)
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