Alcohol-Induced Liver Disease: Clinical, Molecular Mechanism, Pathology, Therapeutics

Dear Colleagues,

Alcohol-induced Liver Disease (ALD) is presented as steatosis caused by alcohol misuse. Often, ALD occurs in conjunction with other metabolic disorders such as high cholesterol, obesity, and diabetes. ALD is underdiagnosed due to a lack of evidence of heavy drinking or symptoms. Alcoholic Steatohepatitis (ASH) is a severe form of ALD, where fibrosis of the liver tissue occurs. It is a serious condition that can progress to cirrhosis and potentially result in the need for liver transplantation or death. 

Other possible subjects include the following:

1. Consumption of alcoholic beverages belongs to the everyday "diet" in many countries, independent of the time of the day, during meals or outside of the meals, and independent of the type of alcohol. This has to be taken into account when approaching a patient with ALD. Often, in fact, it may be difficult to diagnose a pure alcoholic liver disease, to establish a follow-up schedule to eventually prevent liver cirrhosis and cancer development.
2. History of liver cirrhosis and HCC development before and after the era of viral hepatitis in the Western world.
3. Alcoholic beverage and tobacco consumption: synergistic damaging noxae?
4. ALD and distilled alcoholic beverages.
5. Diagnostic tests of alcohol consumption.
6. Animal models of alcoholic liver damage.
7. Sugar (glucose, fructose, xylose) and alcohol consumption synergistic effects in liver damage.

Prof. Dr. Giuliano Ramadori
Prof. Dr. Manuela G. Neuman
Guest Editors

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• alcohol-induced liver damage
• acute alcoholic hepatitis
• viruses and alcohol drinking
• models of alcohol toxicity
• hyper-glycemia and alcohol
• fructose, glucose and alcohol liver disease
• role of alcohol industry in safe drinking