To Phosphorylate and to Be Phosphorylated: From Physiology to Therapeutic Opportunities in LRRK2-Linked Parkinson’s Disease

Dear Colleagues,

Genetic variation around the Leucine-rich repeat kinase 2 (LRRK2) gene affects the risk of both familial and sporadic Parkinson's disease. As LRRK2 mutations are a gain-of-function process, small molecules targeting its kinase activity are currently under clinical evaluation as Parkinson’s therapeutics. LRRK2 is a complex kinase/GTPase controlling multiple endolysosomal and cytoskeletal processes by phosphorylating a subset of RAB GTPases in neuronal and immune cells. LRRK2 itself is extensively phosphorylated and increasing evidence points to a complex interplay among kinases and phosphatases acting directly on LRRK2 or indirectly on its binding/substrate partners. This Special Issue aims to collect the critical research of major experts in the LRRK2 field to draw a comprehensive overview of how phosphorylation affects the pathophysiology of LRRK2 and how the “phospho-LRRKome” may inform novel therapeutical approaches against Parkinson's disease.

Dr. Elisa Greggio
Dr. Salvatore Novello
Guest Editors

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• LRRK2
• kinases
• phosphatases
• therapeutics
• Parkinson’s disease