Genetic and Epigenetic Mechanisms in Gametogenesis and Early Development: Insights from Models, Stem Cells, and Human Disorders

Dear Colleagues,

The successful transmission of genetic information across generations depends on the precise coordination of gametogenesis and the earliest stages of embryonic development. Over the past decade, rapid advances in genetics, epigenomics, single-cell technologies, and imaging have reshaped our understanding of how germ cells are specified, how epigenetic programs are established and reprogrammed, and how these processes collectively influence fertilization, early lineage decisions, and developmental competence.

Gametogenesis is governed by the complex interplay among transcriptional networks, chromatin remodeling, and tightly regulated epigenetic marks. These mechanisms ensure not only the proper formation and maturation of sperm and oocytes but also the establishment of totipotency and developmental potential in the zygote. Meanwhile, early embryo development represents a critical window during which epigenetic asymmetry is resolved, parental genomes undergo extensive reprogramming, and the foundation for embryonic and extraembryonic lineages is laid. Disruptions to these processes can lead to infertility, early pregnancy loss, congenital disorders, or long-term health consequences.

This Special Issue will bring together original research articles, reviews, and perspectives to enhance our understanding of the genetic and epigenetic mechanisms driving gametogenesis and early embryogenesis. Contributions may include, but are not limited to, the following topics:

• Molecular and cellular regulation of germ cell specification and maturation;
• Epigenetic reprogramming during fertilization and early cleavage stages;
• Chromatin architecture, non-coding RNAs, and regulatory networks in early development;
• Genetic and epigenetic determinants of oocyte and sperm quality;
• Molecular causes of infertility or early developmental failure;
• Comparative or evolutionary perspectives on germline and early embryo biology.

We look forward to receiving contributions that will advance this field and help elucidate the fundamental mechanisms underlying successful reproduction and early development.

Prof. Dr. Lon J. van Winkle
Prof. Dr. Philip Iannaccone
Dr. Rebecca Jean Ryznar
Guest Editors

Prof. Dr. Lon J. van Winkle
Prof. Dr. Philip Iannaccone
Prof. Dr. Rebecca Jean Ryznar
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• gametogenesis
• germline development
• early embryogenesis
• epigenetic regulation
• chromatin organization
• cell fate
• developmental gene regulation
• embryonic lineage formation
• evolutionary developmental biology