Genetic and Epigenetic Mechanisms on Psoriasis
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".
Deadline for manuscript submissions: closed (10 June 2022) | Viewed by 396
Special Issue Editor
Medical Center, Faculty of Medicine, Institute of Human Genetics, University of Freiburg, 79106 Freiburg, Germany
Interests: genodermatoses; keratinization disorders; ichthyoses; psoriasis; NGS; genotyping; association studies; whole exome sequencing
Interests: genodermatoses; keratinization disorders; ichthyoses; psoriasis; NGS; genotyping; association studies; whole exome sequencing
Special Issue Information
Dear Colleagues,
Psoriasis is a multifactorial disease, predominantly caused by genetic factors. Psoriasis vulgaris (PV) accounts for about 90% of cases, and one third of psoriasis patients are also affected by psoriatic arthritis (PsA).
Psoriasis is a clearly hereditary disease; twin studies have shown that identical twins are 2–3 times more likely to have psoriasis than dizygotic twins. In the last 2 decades, over 80 different genetic loci have been identified. Human leukocyte antigen (HLA) genes are most strongly associated with psoriasis risk, particularly HLA-C*06:02.
This Special Issue aims to provide a comprehensive and updated overview of genetic and epigenetic mechanisms of psoriasis. This includes genetic studies based on genomic analyses using the latest NGS methods, which may reveal new diagnostic biomarkers, or model systems that can explain pathophysiological mechanisms and provide new therapeutic approaches. To expand knowledge on such complex topics, contributions from experts in the field are needed in the form of research papers and critical reviews.
Psoriasis is a multifactorial disease, predominantly caused by genetic factors. Psoriasis vulgaris (PV) accounts for about 90% of cases, and one third of psoriasis patients are also affected by psoriatic arthritis (PsA).
Psoriasis is a clearly hereditary disease; twin studies have shown that identical twins are 2–3 times more likely to have psoriasis than dizygotic twins. In the last 2 decades, over 80 different genetic loci have been identified. Human leukocyte antigen (HLA) genes are most strongly associated with psoriasis risk, particularly HLA-C*06:02.
This Special Issue aims to provide a comprehensive and updated overview of genetic and epigenetic mechanisms of psoriasis. This includes genetic studies based on genomic analyses using the latest NGS methods, which may reveal new diagnostic biomarkers, or model systems that can explain pathophysiological mechanisms and provide new therapeutic approaches. To expand knowledge on such complex topics, contributions from experts in the field are needed in the form of research papers and critical reviews.
Prof. Dr. Judith Fischer
Guest Editor
Keywords
- psoriasis genetics
- epigenetic mechanisms in psoriasis
- psoriasis risk genes
- psoriasis pathways
- therapeutic targets
- psoriasis and biologicals
- NGS
- whole-exome sequencing WES
- whole-genome sequencing WGS
- genomic analyses
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