Genetic Basis of Rare Inherited Dentin Disorders
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".
Deadline for manuscript submissions: closed (20 December 2024) | Viewed by 351
Special Issue Editors
Interests: biomaterials; dentistry; biomolecular medicine; dental development and regeneration; organ-on-a-chip; tissue Engineering
Special Issues, Collections and Topics in MDPI journals
Interests: tooth development; amelogenesis; dentinogenesis; rare diseases; NGS; WES; WGS
Special Issue Information
Dear Colleagues,
Inherited Dentin Disorders (IDDs) encompass two groups of diseases: dentinogenesis imperfecta (DI) and dentin dysplasia (DD), characterized by abnormal dentin structure and arise from disturbances in the dentinogenesis process. These anomalies affect either the primary dentition, or both the primary and permanent dentitions. They are characterized by great diversity in phenotypic expression and they can be associated with syndromes, such as osteogenesis imperfecta (OI) or isolated forms. For most of them, the predominant mode of inheritance is autosomal dominant. Thanks to a better understanding of the genes responsible for IDDs, the Schields’s classification has recently been revised, based on the correlation between genetic data and the phenotypic manifestations of the diseases.
This special issue aims to provide new insights into the pathophysiology and molecular basis of IDDs, with a focus on both fundamental and translational studies. Participants in this issue might to highlight the genetic heterogeneity of mutations found in disease-specific genes, explore genotype-phenotype associations, investigate innovative cellular or animal models or new tissue engineering technologies applied to the study of the molecular events underlying these abnormalities, describe the development and improvement of diagnostic tools and describe new therapeutic approaches. Research articles and critical reviews are welcome in this issue.
Dr. Isaac-Maximiliano Bugueno
Prof. Dr. Agnès Bloch-Zupan
Guest Editors
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Keywords
- dentinogenesis
- dentinogenesis imperfecta
- dentin dysplasia
- molecular diagnostics
- genetics
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