Advances in Genetics and Genomics of Liver Diseases
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 25 July 2025 | Viewed by 106
Special Issue Editors
Interests: GWAS; steatotic liver disease; CRISPR; variant to function
Interests: nonalcoholic fatty liver disease; alcoholic liver disease; liver transplant; fibrogenesis; single-cell transcriptomics; spatial transcriptomics
Special Issue Information
Dear Colleagues,
Precision medicine and genomic analysis have transformed clinical practice in adult oncology and pediatric medicine. Genomic approaches are increasingly being used in hepatology clinical practice, and in the research setting, human genetics and genomics have been used to successfully improve our understanding of the underlying biology of both rare and common forms of liver disease. Indeed, in recent years, directed therapies for metabolic-dysfunction-associated steatohepatitis have entered the clinic based on target discovery from human genome-wide association studies.
However, the majority of the inherited basis of chronic liver disease remains unexplained. There remains great potential to discover novel disease mechanisms and novel therapeutic targets through human genetic studies. Even for existing genetic association studies in liver disease, understanding the connection of genomic loci to target genes, relevant cell types, and disease mechanism remains poorly understood for the vast majority of disease-associated loci.
This Special Issue invites novel studies and review articles that address all facets of the study of the genetics and genomics of chronic liver disease. These include, but are not limited to, clinical genomics, research genomics, functional genomics, the genetic basis of Mendelian liver diseases, the genetic basis of common liver diseases, epidemiology, meta-analysis, variant-to-function approaches, single-cell studies, molecular mechanisms of disease, preclinical research, case series, novel case reports, or efforts to develop new therapeutics targeting known or novel causal genes and pathways. We look forward to your contributions.
Dr. Aaron Hakim
Dr. Z. Gordon Jiang
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- GWAS
- human genetics
- chronic liver disease
- causal genes
- disease mechanisms
- Mendelian liver diseases
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