Advancing Precision Medicine for Lung Cancer Through Genomics
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".
Deadline for manuscript submissions: 25 May 2026 | Viewed by 82
Special Issue Editor
2. Genomics Core Facility, G-STeP, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy
Interests: genomics; lung cancer; liquid biopsy; tissue biopsy; molecular biology; cancer genomics; precision medicine; next-generation sequencing; proteogenomics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Lung cancer is a complex molecular disease driven by several genomic alterations occurring in pulmonary cells, often triggered by carcinogens in tobacco smoke, environmental pollutants, or occupational hazards. Recent advancements in genomics and multi-omics approaches have revealed that lung cancer development and evolution involves sequential genetic and epigenetic changes in tumor cells.
Breakthroughs in next-generation sequencing (NGS) and single-cell genomics have enabled comprehensive profiling of tumor heterogeneity, identifying actionable mutations and resistance mechanisms. These discoveries have directly informed the development of targeted therapies, which have revolutionized treatment for patients with specific genomic alterations. Additionally, liquid biopsy technologies and circulating tumor DNA (ctDNA) analysis now allow non-invasive monitoring of tumor dynamics and resistance emergence, critical for adaptive precision medicine strategies.
This Special Issue seeks to highlight cutting-edge genomic insights that advance precision medicine for lung cancer. We invite original research and reviews on the following topics:
- Discovery of novel biomarkers for early detection, prognosis, and treatment prediction.
- Validation of genomic targets for next-generation therapies, including small-molecule inhibitors, bispecific antibodies, and gene-editing technologies.
- Bioinformatics and statistical methodologies for integrating multi-omics data to refine risk stratification and therapeutic decision-making.
- Translational studies demonstrating the clinical utility of genomic profiling in personalized treatment pathways.
By bridging genomic discovery with clinical application, this collection aims to accelerate the development of individualized therapeutic strategies, ultimately improving outcomes for lung cancer patients through precision medicine.
Dr. Elisa De Paolis
Guest Editor
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- lung cancer
- liquid biopsy
- tissue biopsy
- next-generation sequencing
- genomics
- clinical medicine
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