Recent Advances in the Discovery of Anti-Inflammatory Compounds

A special issue of Future Pharmacology (ISSN 2673-9879).

Deadline for manuscript submissions: 28 February 2026 | Viewed by 358

Special Issue Editors


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Guest Editor
Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
Interests: cardiovascular pathophysiology; oxidative stress; neuroinflammation; ischemia-reperfusion injury; nitric-oxide; immune response

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Guest Editor
Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia
Interests: drug discovery; synthesis; characterization; computational chemistry; anti-inflammatory drugs; anticancer drugs

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Guest Editor
Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia
Interests: drug discovery; synthesis; characterization; computational chemistry; anti-inflammatory drugs; anticancer drugs; in vitro enzyme inhibition

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to this Special Issue, which aims to highlight recent progress in the identification, design, and development of novel compounds with anti-inflammatory activity, including both synthetic molecules and natural products.

Inflammation is a complex biological response to harmful stimuli such as pathogens, cell damage, or irritants. Although it is a crucial component of the body’s defense system, chronic or uncontrolled inflammation has been strongly associated with the pathogenesis of a wide range of diseases, including autoimmune disorders, neurodegenerative diseases, cardiovascular conditions, metabolic syndromes, and cancer. Therefore, the discovery of novel compounds with improved pharmacological profiles, improved selectivity, and lower toxicity is of particular importance.

This Special Issue aims to provide a comprehensive overview of current trends, challenges, and breakthroughs in the discovery of new anti-inflammatory compounds. We welcome original research and review articles that address the design, synthesis, characterization, and biological evaluation of novel anti-inflammatory agents, as well as studies employing computational approaches and in vitro/in vivo assays to elucidate their mechanisms of action and therapeutic potential.

We look forward to receiving your contributions to this exciting Special Issue and advancing the field of anti-inflammatory drug discovery together.

Dr. Ivan M. Srejović
Dr. Nikola Nedeljkovic
Dr. Miloš Nikolić
Guest Editors

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Keywords

  • anti-inflammatory agents
  • acute and chronic inflammation
  • drug discovery
  • synthetic derivatives
  • natural product chemistry
  • in silico, in vitro, and in vivo evaluation

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Published Papers (1 paper)

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Research

27 pages, 5735 KB  
Article
Targeting Oxidative Stress and Inflammation with Vitis vinifera Leaf Extract: A Combined Experimental and Computational Pharmacological Study
by Sanja Djakovic, Marina Nikolic, Ivan Srejovic, Nikola Nedeljkovic, Marko Karovic, Jovana Bradic, Marijana Andjic, Vladimir Jakovljevic and Milos Nikolic
Future Pharmacol. 2025, 5(3), 52; https://doi.org/10.3390/futurepharmacol5030052 - 14 Sep 2025
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Abstract
Objectives: Our study aimed to examine the antioxidative and anti-inflammatory potential of the lyophilized aqueous leaf extract of Vitis vinifera. Methods: The antioxidant capacity of the extract was evaluated using the DPPH and FRAP assays. The in vivo phase of [...] Read more.
Objectives: Our study aimed to examine the antioxidative and anti-inflammatory potential of the lyophilized aqueous leaf extract of Vitis vinifera. Methods: The antioxidant capacity of the extract was evaluated using the DPPH and FRAP assays. The in vivo phase of the study included 40 male Wistar albino rats. One half of the animals were used to induce the carrageenan model of acute inflammation, while the other half were used for examination of the extract effect on the redox state. Rats from the experimental group drank tap water containing 150 mg/kg Vitis vinifera extract for 14 days, while control animals received saline at the same volume. The molecular docking studies of polyphenols present in the leaf extract were conducted in AutoDock Vina. Results: In vitro assessment of the antioxidative capacity of the applied extract revealed significant free radical scavenging activity (IC50 value 11.63 µg/mL), along with a pronounced ferric reducing ability (0.143 at 700 nm). Moreover, animal treatment with the extract led to significant paw edema inhibition (30.34%, 35.06%, and 41.54% in the second, third, and fourth hours, respectively) and to pro-oxidative marker reduction. Additionally, Vitis vinifera extract significantly increased catalase activity and glutathione levels. The in silico results showed that rutin binds to cyclooxygenase 1 (−8.2 kcal/mol) and 2 (−8.3 kcal/mol), as well as to antioxidant enzymes (catalase: −8.6 kcal/mol, SOD: −7.4 kcal/mol), indicating its key role in mediating the biological activity of the tested extract. Conclusions: This study highlights the significant antioxidant and anti-inflammatory potential of V. vinifera lyophilized aqueous leaf extract from the Serbian market, supported by both in vivo and in silico analyses. Full article
(This article belongs to the Special Issue Recent Advances in the Discovery of Anti-Inflammatory Compounds)
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