Microbes and Medicine—Papers from the 2025 OBASM Meeting

A special issue of Drugs and Drug Candidates (ISSN 2813-2998).

Deadline for manuscript submissions: 30 October 2025 | Viewed by 441

Special Issue Editors


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Guest Editor
Department of Biology and Toxicology, Ashland Univeristy, Ashland, OH 44805, USA
Interests: bacteriophage; phage therapy; host range; phage evolution; phage receptor; phage-host co-evolution
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Guest Editor
Department of Biology and Earth Science, Otterbein University, Westerville, OH, USA
Interests: bacterial signaling pathways; biochemistry; microscopy; microbial genetics; genetics; bioinformatics

Special Issue Information

Dear Colleagues,

The 2025 annual meeting of the Ohio Branch of the American Society for Microbiology (OBASM) will be held April 4–5 at Otterbein University in Westerville, Ohio. The conference has been designed to provide an overview of all aspects of microbiology, with sessions designed for senior through student researchers. Sessions include talks focusing on medical microbiology and environmental microbiology, examining basic science and applications. More information about the conference can be found at https://ohiobranchasm.org/meetings/meeting-information.

Meeting participants are invited to contribute articles to a Special Issue of Drugs and Drug Candidates. Articles should fall within the scope of the journal, including, but not limited to, papers on

  • Development of new drugs for infectious diseases;
  • Studies of genes that could be potential targets for therapeutic agents;
  • Microbiome modification;
  • Strategies to overcome antimicrobial agent resistance;
  • In vitro and in vivo model evaluation and efficacy testing.

Both review and research articles are sought. Please reach out to the guest editors for questions concerning whether a paper will fit with this Special Issue. While authors do not need to have attended the meeting, the journal has generously waived the article processing fees for attendees of the 2025 OBASM meeting.

Prof. Dr. Paul Hyman
Dr. Jennifer A. Bennett
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Drugs and Drug Candidates is an international peer-reviewed open access quarterly journal published by MDPI.

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Keywords

  • antibiotics
  • antibiotic discovery
  • antibiotic resistance (or antimicrobial resistance)
  • drug design
  • drug discovery
  • medical microbiology
  • microbiology
  • microbes
  • microbiome
  • phage therapy

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Published Papers (1 paper)

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Research

22 pages, 6509 KiB  
Article
Development of Ofloxacin-Loaded CS/PVA Hydrogel for the Treatment of Metritis in Bovine
by Priyanka Kumari, Manish Kumar Shukla, Ashutosh Tripathi, Janmejay Pandey and Amit K. Goyal
Drugs Drug Candidates 2025, 4(2), 17; https://doi.org/10.3390/ddc4020017 - 16 Apr 2025
Viewed by 249
Abstract
Background: Metritis, a common postpartum uterine infection in bovines, poses substantial challenges in livestock management, including compromised fertility and economic losses. Poor uterine drug penetration and systemic side effects, necessitating innovative localised delivery systems and limiting current systemic antibiotic treatments. Aim: [...] Read more.
Background: Metritis, a common postpartum uterine infection in bovines, poses substantial challenges in livestock management, including compromised fertility and economic losses. Poor uterine drug penetration and systemic side effects, necessitating innovative localised delivery systems and limiting current systemic antibiotic treatments. Aim: This study aimed to develop and evaluate the potential effect of the ofloxacin-loaded hydrogel as a localised drug delivery system to treat metritis in bovine. The focus was on achieving sustained drug release, enhanced antibacterial efficacy and reduced inflammation in the endometrium. Materials and Methods: The CS/PVA hydrogel was synthesised using a freeze–thaw method and further optimised for drug encapsulation efficiency (96.7 ± 2.1%), stability and biocompatibility. Physicochemical characterisation included swelling behaviour, mechanical properties and rheological analysis. In vitro drug release profiles in the simulated uterine fluid were assessed over 72 h and antibacterial activity was tested against common uterine pathogens such as Escherichia coli and S. aureus. In vivo studies were conducted on bovines diagnosed with endometritis to evaluate clinical recovery. Results: The SEM image of the ofloxacin-loaded CS/PVA hydrogel resulted in a smooth and porous structure demonstrating larger pore size than the blank. The rheological study suggested higher stability and elastic behaviour. Antibacterial assays on E. coli and S. aureus revealed significant inhibition zones, respectively, indicating potent efficacy. In vivo, evaluated on treated bovine, reduced bacterial loads were exhibited (2.86 × 105A CFU/mL → 6.37 × 102B CFU/mL), clinical improvement was marked and uterine inflammation was resolved. Conclusions: Ofloxacin-loaded hydrogels represent a promising localised treatment for bovine metritis, offering sustained antibacterial action and improved clinical outcomes. This approach addresses the limitations of systemic antibiotic therapies and provides a practical solution for enhanced veterinary care. Further studies are recommended to validate these findings in more extensive field trials and explore commercialisation potential. Full article
(This article belongs to the Special Issue Microbes and Medicine—Papers from the 2025 OBASM Meeting)
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