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Clinics and Practice
Special Issues
Urologic Oncology: Recent Advances and Future Perspectives
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Urologic Oncology: Recent Advances and Future Perspectives

A special issue of Clinics and Practice (ISSN 2039-7283).

Deadline for manuscript submissions: closed (15 September 2024) | Viewed by 3130

Special Issue Editors

Prof. Dr. Riccardo Autorino

E-Mail Website
Guest Editor
Department of Urology, Rush University Medical Center, Chicago, IL, USA
Interests: prostate cancer; laparoscopic surgery; minimally invasive surgery; surgical oncology; robotic surgery; bladder cancer
Special Issues, Collections and Topics in MDPI journals
Dr. Celeste Manfredi

E-Mail Website
Guest Editor
1. Unit of Urology, Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy
2. Department of Urology, Rush University Medical Center, Chicago, IL, USA
Interests: urology; uro-oncology; andrology; sexual medicine; benign prostatic hyperplasia
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Urologic cancer research is a dynamic and critical field dedicated to unraveling the characteristics of tumors affecting the genitourinary system. Its primary aim is to advance our understanding of urologic cancer in order to improve the management of these complex diseases.

Researchers tirelessly explore the intricate genetic and molecular mechanisms underlying the initiation and progression of urological cancers, paving the way for personalized diagnostic and therapeutic strategies. Robotic surgery has become widespread, being already a cornerstone in the treatment of many urologic malignancies. Continuous efforts are being conducted by scientists to improve the accuracy of diagnostic tools, the efficacy and safety of medical treatments, the outcomes of surgical techniques, and, ultimately, the patients' prognosis and quality of life.

In this Special Issue, we invite authors to submit papers on recent advances and future perspectives regarding epidemiology, risk factors, pathophysiology, diagnosis, and/or treatment of the main urologic tumors.

Prof. Dr. Riccardo Autorino
Dr. Celeste Manfredi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Clinics and Practice is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • prostate cancer
  • bladder cancer
  • upper tract urothelial cancer
  • testicular cancer
  • renal cancer
  • adrenal cancer
  • penis cancer
  • robotic surgery
  • personalized medicine

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Published Papers (1 paper)

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Research

13 pages, 875 KiB  
Article
Tissue-Based Genomic Testing in Prostate Cancer: 10-Year Analysis of National Trends on the Use of Prolaris, Decipher, ProMark, and Oncotype DX
by Eugenio Bologna, Francesco Ditonno, Leslie Claire Licari, Antonio Franco, Celeste Manfredi, Spencer Mossack, Savio Domenico Pandolfo, Cosimo De Nunzio, Giuseppe Simone, Costantino Leonardo and Giorgio Franco
Clin. Pract. 2024, 14(2), 508-520; https://doi.org/10.3390/clinpract14020039 - 19 Mar 2024
Cited by 5 | Viewed by 2283
Abstract
Background: Prostate cancer (PCa) management is moving towards patient-tailored strategies. Advances in molecular and genetic profiling of tumor tissues, integrated with clinical risk assessments, provide deeper insights into disease aggressiveness. This study aims to offer a comprehensive overview of the pivotal genomic tests [...] Read more.
Background: Prostate cancer (PCa) management is moving towards patient-tailored strategies. Advances in molecular and genetic profiling of tumor tissues, integrated with clinical risk assessments, provide deeper insights into disease aggressiveness. This study aims to offer a comprehensive overview of the pivotal genomic tests supporting PCa treatment decisions, analyzing—through real-world data—trends in their use and the growth of supporting literature evidence. Methods: A retrospective analysis was conducted using the extensive PearlDiver™ Mariner database, which contains de-identified patient records, in compliance with the Health Insurance Portability and Accountability Act (HIPAA). The International Classification of Diseases (ICD) and Current Procedural Terminology (CPT) codes were employed to identify patients diagnosed with PCa during the study period—2011 to 2021. We determined the utilization of primary tissue-based genetic tests (Oncocyte DX®, Prolaris®, Decipher®, and ProMark®) across all patients diagnosed with PCa. Subsequently, within the overall PCa cohort, patients who underwent radical prostatectomy (RP) and received genetic testing postoperatively were identified. The yearly distribution of these tests and the corresponding trends were illustrated with graphs. Results: During the study period, 1,561,203 patients with a PCa diagnosis were recorded. Of these, 20,748 underwent tissue-based genetic testing following diagnosis, representing 1.3% of the total cohort. An increasing trend was observed in the use of all genetic tests. Linear regression analysis showed a statistically significant increase over time in the use of individual tests (all p-values < 0.05). Among the patients who underwent RP, 3076 received genetic analysis following surgery, representing 1.27% of this group. Conclusions: Our analysis indicates a growing trend in the utilization of tissue-based genomic testing for PCa. Nevertheless, they are utilized in less than 2% of PCa patients, whether at initial diagnosis or after surgical treatment. Although it is anticipated that their use may increase as more scientific evidence becomes available, their role requires further elucidation. Full article
(This article belongs to the Special Issue Urologic Oncology: Recent Advances and Future Perspectives)
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