Advances in Medicinal Chemistry for Drug Discovery and Development

A special issue of AppliedChem (ISSN 2673-9623).

Deadline for manuscript submissions: 31 May 2026 | Viewed by 191

Special Issue Editor


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Guest Editor
Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY 40506, USA
Interests: anticancer; heterocyclic compounds; small molecules; drug discovery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

While remarkable progress has been made in combating many diseases, the global burden of cancer, cardiovascular and cerebrovascular diseases, and diabetes continues to grow. For these conditions, gaps in our understanding of pathogenesis, along with limitations in current medical technologies, continue to pose significant challenges. Thus, innovative approaches and novel next-generation drugs are urgently needed. Natural products and designed small heterocyclic molecules remain invaluable in this effort, forming the basis of most drugs used in clinical practice. We invite researchers to contribute original studies and insightful reviews that highlight breakthroughs, opportunities, and challenges in harnessing natural and designed molecules for drug discovery.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  • Discovery of novel natural and synthesized drug molecules;
  • Structural determination of bioactive molecules;
  • Advances in the application of established molecules in drug discovery;
  • Computer-aided drug design and molecular modeling approaches;
  • Structure–activity relationship (SAR) studies between molecules and their biological targets.

Dr. Suresh Narva
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. AppliedChem is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • anticancer
  • heterocyclic compounds
  • small molecules
  • drug discovery

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Published Papers

This special issue is now open for submission.
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