Autoimmunity Induced Thrombosis
A special issue of Antibodies (ISSN 2073-4468). This special issue belongs to the section "Antibody-Based Diagnostics".
Deadline for manuscript submissions: closed (20 January 2023) | Viewed by 258
Special Issue Editor
Interests: hemostasis; coagulation; thrombosis; fibrinolysis; autoantibodies; pathogenicity; laboratory methods; molecular mechanisms
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Although rare and isolated, some thrombotic events are induced by the development of autoantibodies to hemostasis proteins, to blood cells, or to factors involved in coagulation and fibrinolysis. Circumstances associated to these autoimmune complications concern infectious diseases, drug treatments, or pathologies like malignancy. Many studies aim to understand the causative factors which provoke this immune response in very rare individuals, whilst the vast majority are preserved. The unexpected and hazardous complex formation of infectious components or drugs with body proteins could lead to this immunization, but individual factors could also be responsible.
Many different autoantibodies which can favor the occurrence of thrombotic diseases have been reported. They concern, for example, β2-glyco-protein 1, prothrombin, thrombin, protein S, factor V, thrombomodulin, platelet factor 4, ADAMTS-13, and annexin V. Other autoantibodies are more associated to bleeding disorders like those targeted to factor VIII, von Willebrand factor, or to platelet surface glyco-proteins, and will not be addressed in this Issue.
Identifying a pathogenic autoantibody and characterizing it is essential to first stop or control the inducing cause. Dedicated and highly specialized laboratory tools are available for these investigations. The capture antigen used is critical to allow the correct binding activity, and must expose the epitopes involved in pathogenicity.
Potential therapies for these complications aim to treat the symptoms (e.g., through the use of anticoagulants), or to reduce the autoimmune response with drugs like corticoids.
This Issue aims to review autoantibodies involved in thrombotic complications, the causes provoking their development, pathological mechanisms and outcome, and available treatments.
The topics of interest for this Special Issue include, but are not limited to:
- Basic and fundamental aspects;
- The various thrombotic diseases induced by autoantibodies, often acquired (drug, malignancy or infection induced);
- Laboratory diagnosis of these antibodies;
- Medical care for affected patients;
- Follow-up of disease course.
Dr. Jean Amiral
Guest Editor
Manuscript Submission Information
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