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Pediatric Reports
Volume 3
Issue 3
10.4081/pr.2011.e18
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Case Report

Combination Antifungal Therapy and Surgery for the Treatment of Invasive Pulmonary Aspergillosis After Hematopoietic Stem Cell Transplantation

by
Simone Cesaro
,
Marta Pillon
*,
Elisabetta Calore
,
Rita Alaggio
,
Piergiorgio Gamba
,
Silvia Bergamo
,
Chiara Mainardi
,
Tiziana Toffolutti
,
Anna Pegoraro
and
Chiara Messina
1
Pediatric Hematology Oncology,Department of Pediatrics, Padova, Italy
2
Department of Pathology, University of Padova, Italy
3
Pediatric Surgery, Departmentof Pediatrics, Padova, Italy
4
PediatricRadiology, Department of Pediatrics, Padova, Italy
*
Author to whom correspondence should be addressed.
Pediatr. Rep. 2011, 3(3), e18; https://doi.org/10.4081/pr.2011.e18
Submission received: 31 March 2011 / Revised: 14 June 2011 / Accepted: 14 June 2011 / Published: 13 July 2011

Abstract

An 8-year old boy, affected by severe aplastic anemia, developed a probable pulmonary invasive aspergillosis (IA) early after a second unrelated allogeneic hematopoietic stem cell transplant (HSCT). He was treated promptly with the combination of liposomal amphotericin B and caspofungin. Despite the initial stabilization, the patient deteriorated and the antifungal therapy was switched to voriconazole and caspofungin. The patient gradually improved and was discharged home on day +29 post-HSCT on oral voriconazole. On day +119, a sudden episode of hemoptysis occurred and a right superior lobectomy was decided to remove the residual aspergilloma. The patient is now alive and well more than 24 months from HSCT. This case demonstrated that antifungal combination therapy and surgery are valid options to cure pulmonary IA even in patients at high-risk and severely immunosuppressed.
Keywords: Aspergillosis spp.; hematopoietic stem cell transplantation; severe aplastic anemia Aspergillosis spp.; hematopoietic stem cell transplantation; severe aplastic anemia

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MDPI and ACS Style

Cesaro, S.; Pillon, M.; Calore, E.; Alaggio, R.; Gamba, P.; Bergamo, S.; Mainardi, C.; Toffolutti, T.; Pegoraro, A.; Messina, C. Combination Antifungal Therapy and Surgery for the Treatment of Invasive Pulmonary Aspergillosis After Hematopoietic Stem Cell Transplantation. Pediatr. Rep. 2011, 3, e18. https://doi.org/10.4081/pr.2011.e18

AMA Style

Cesaro S, Pillon M, Calore E, Alaggio R, Gamba P, Bergamo S, Mainardi C, Toffolutti T, Pegoraro A, Messina C. Combination Antifungal Therapy and Surgery for the Treatment of Invasive Pulmonary Aspergillosis After Hematopoietic Stem Cell Transplantation. Pediatric Reports. 2011; 3(3):e18. https://doi.org/10.4081/pr.2011.e18

Chicago/Turabian Style

Cesaro, Simone, Marta Pillon, Elisabetta Calore, Rita Alaggio, Piergiorgio Gamba, Silvia Bergamo, Chiara Mainardi, Tiziana Toffolutti, Anna Pegoraro, and Chiara Messina. 2011. "Combination Antifungal Therapy and Surgery for the Treatment of Invasive Pulmonary Aspergillosis After Hematopoietic Stem Cell Transplantation" Pediatric Reports 3, no. 3: e18. https://doi.org/10.4081/pr.2011.e18

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