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Gout, Urate, and Crystal Deposition Disease, Volume 2, Issue 3

September 2024 - 5 articles

Cover Story: Age-related calcification is an increasing concern, impacting tissues throughout the body and affecting millions of people. This review examines the current understanding of how aging contributes to calcification in various human tissues. Additionally, we explore the murine models that have proven valuable for investigating the complexities of this process. Finally, we delve into the molecular mechanisms by which aging influences calcification, including cellular senescence, reduced pyrophosphate levels, and heightened oxidative stress and pro-mineralizing cytokines. View this paper
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Articles (5)

  • Conference Report
  • Open Access
2,925 Views
40 Pages

The 15th European Crystal Network (ECN) Workshop—2024 ECN Abstract Proceedings

  • Frédéric Lioté,
  • Fernando Perez-Ruiz,
  • Hang-Korng Ea,
  • Tristan Pascart,
  • Tony Merriman and
  • Alexander So

15th Anniversary this year: the ECN workshop is set up in Paris, down town. Every year ECN workshop offers a unique opportunity for clinicians and researchers interested in crystals, inflammation, crystal-induced diseases including gout, to present t...

  • Review
  • Open Access
2 Citations
5,882 Views
9 Pages

Periarticular Calcifications: Clinical Features and Treatment Options

  • Romain Dalla-Torre,
  • Benoit Le Goff and
  • Christelle Darrieutort-Laffite

Periarticular calcifications are a common condition for rheumatologists. They are characterized by deposition of carbonated apatite in tendons or connective tissues around joints. It most commonly affects patients between 30 and 60, and the main loca...

  • Article
  • Open Access
2,587 Views
14 Pages

Obesity-Associated Hyperuricemia in Female Mice: A Reevaluation

  • Andrew P. Giromini,
  • Sonia R. Salvatore,
  • Brooke A. Maxwell,
  • Sara E. Lewis,
  • Michael R. Gunther,
  • Marco Fazzari,
  • Francisco J. Schopfer,
  • Roberta Leonardi and
  • Eric E. Kelley

Many preclinical reports have coalesced to identify a strong association between obesity and increased levels of uric acid (UA) in tissues and, importantly, in the circulation (hyperuricemia). Unfortunately, nearly all these studies were conducted wi...

  • Review
  • Open Access
3 Citations
4,274 Views
16 Pages

Age-Associated Calcification: Insights from Murine Models

  • Sonia Nasi,
  • Mario Romani and
  • Nathalie Busso

Calcification refers to the deposition of calcium-containing crystals either intracellularly or within the extracellular matrix. Physiologic calcification is a normal process occurring during bone and tooth development and growth. In contrast, pathol...

  • Review
  • Open Access
3 Citations
6,324 Views
16 Pages

Gout Basic Research: 2023 in Review

  • Maria Muntiu,
  • Leo A. B. Joosten and
  • Tania O. Crişan

Gout is a prevalent form of inflammatory arthritis caused by the crystallization of uric acid in the joints and soft tissues, leading to acute, painful attacks. Activation of the NLRP3 inflammasome in mononuclear cells, along with inflammasome-indepe...

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Gout Urate Cryst. Depos. Dis. - ISSN 2813-4583Creative Common CC BY license