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Review
Peer-Review Record

Plant-Derived Natural Products: A Source for Drug Discovery and Development

Drugs Drug Candidates 2024, 3(1), 184-207; https://doi.org/10.3390/ddc3010011
by Noureddine Chaachouay 1,* and Lahcen Zidane 2
Reviewer 2: Anonymous
Reviewer 3: Anonymous
Reviewer 4: Anonymous
Drugs Drug Candidates 2024, 3(1), 184-207; https://doi.org/10.3390/ddc3010011
Submission received: 8 November 2023 / Revised: 21 December 2023 / Accepted: 25 January 2024 / Published: 19 February 2024
(This article belongs to the Section Drug Candidates from Natural Sources)

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

Comments:

Introduction should be enlarged discussing previous review on the topic.

All manuscript needs more in-depth discussion, including more examples and approaches. In-depth discussion on the secondary metabolites and the use of plant-derived products in the Traditional Pharmacopeias are needed.

Author Response

Dear Prof.

Please see attached document

Author Response File: Author Response.pdf

Reviewer 2 Report

Comments and Suggestions for Authors

It a an review article that try summarizes an overview the plant-derived natural products as drug discovery and candidates in drug development. The idea is fine, however in many part the review is too general. This is my main critical concern. Therefore, I recommend to provide more details to this review.   Minor comments    The Figure 1 is informative and good designed. Table 1 Berberis vulgaris – should be Berberis vulgaris L.  As in chapter 3 you gave a historical overview , the 3. 3 and 3.4 should be over changed; i.e give Quinine: A Malaria Breakthrough from Cinchona (17th Century) before 3.3. Aspirin: A Gift from the Willow Tree (19th Century); his will allow you to maintain the chronological order.

 L 70 – you declared the review of 97 papers, meanwhile in the Reference list I found 165 papers????

 L 165  Give some more detailed information

Scientists can use the innate protective mechanisms of plants to create medications that specifically target certain illnesses or situations [44].

L 293  = you mentioned the report; what report; the reference is needed

L 305-311 be more consequent; for polyphenols the examples are given; give the examples also for flavonoids; fruits vegetables – it very broad; be more precise

L 313-317 – no references at all. ; and very general statement is given. Present more details.

L 358 -359 Moreover, natural products exhibit a broader spectrum of molecular attributes, such as reduced structural diversity, partition coefficient, and molecular mass [103, 104].

Again, it is very broad statement; give some examples

L 455-468 – no references; it is required in review article. 

 

Author Response

Dear Prof.

Please see attached document

Author Response File: Author Response.pdf

Reviewer 3 Report

Comments and Suggestions for Authors

In review article entitled “Plant-Derived Natural Products: A Source for Drug Discovery and Development” current advancements and future approaches for discovering natural items such as health and wellness-promoting remedies were discussed. Due to medicinal chemists' increasing interest in natural substance drug development, various innovative techniques and technological advances have been created for natural ingredients' selection, identification, isolation, characterization, and biological screening.

The paper is interesting, the methodology is adequate and explicitly stated, the subject is very topical and for this reason, I recommend the publication of this study.

Author Response

Dear Prof.

Please see attached document

Author Response File: Author Response.pdf

Reviewer 4 Report

Comments and Suggestions for Authors

The review is well organized but check the labeling of different chapter (page 7 from 5.6 to 3 ?) In the 5.2 extraction part You described very quickly and with old method! Now there are ecoextraction methods and new biobased solvants.

Author Response

Dear Prof.

Please see attached document

Author Response File: Author Response.pdf

Round 2

Reviewer 1 Report

Comments and Suggestions for Authors

The authors have changed their manuscript according to the reviewer`s recommendation. 

Reviewer 2 Report

Comments and Suggestions for Authors

My comments have been properly  addressed

Reviewer 4 Report

Comments and Suggestions for Authors

The manuscript is more understandable and better described the differents aspects of Drug design using natural compounds. Please recheck the number in chapter 3 ! chapter 6 you could cite the Nagoya protocol for protection of biodiversity.

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