Heat Shock Proteins Mediate Intercellular Communications within the Tumor Microenvironment through Extracellular Vesicles
Abstract
:1. Introduction
2. Extracellular Vesicle (EV)-Mediated Stress Propagation during Tumor Development and Progression
3. Heat Shock Protein (HSP) Secretion by EVs Triggered by Chemo- or Radiotherapy
4. Transfer of Therapy Resistance Mediated by HSP-EVs’ Release by Tumor Cells
5. Cancer Cell Intrinsic Mechanism Modulated by HSP-EVs That Impact Therapy Response
6. Immunological Roles of Cancer HSP-EVs That Impact Therapy Response
7. Future Perspectives
8. Concluding Remarks
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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HSP | Cell Type and Reference |
---|---|
HSP20 | Gynecologic cancer cells [51] |
HSP27 HSC70 HSP70 HSP90 | B cells [29] |
HSP60 | Human lung carcinoma cells [52] |
HSP60 HSP70 | H292, A549 and K562 tumor cell lines [31] |
HSP60 HSP70 HSP90 | Hepatocellular carcinoma cells [53] |
HSP70 | Human peripheral blood mononuclear cells [54] |
HSP70 | Natural killer cells [46] |
HSP70 | Choriocarcinoma cells [23] |
HSP72 | Breast adenocarcinoma cells Erythroleukemic cells [55] |
HSC73 | Dendritic cells [25] |
HSP70 HSP90 | Prostate cancer cell [56] |
mt-HSP70 | Breast cancer cells [32] |
GRP78 | Colon cancer cells [57] |
HSP90 | Cancer stem cell-like [58] |
Chaperone | Activity | |
---|---|---|
Pro-Tumor | Anti-Tumor | |
HSP70 | Promote cell-survival, protect againist oxidative stress and others, promote protein folding and degradation, and promote cell migration and invasion. | Induce tumor cells’ apoptotic death and sensitize them to chemo- or radiotherapies. |
HSP72 | Promote angiogenesis, protect cancer cells from oxidative stress. Supress apoptosis and promote cell invation, and migration. | Favor arresting of tumor growth, promote apoptosis, sensitize to chemotherapy. |
HSP90 | Promote protein folding and stabilization of multiple proteins, promote cell survival, and suppress apoptosis. | Promote apoptosis, sensitize to chemo- and radiotherapy. |
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Saito, R.F.; Machado, C.M.L.; Lomba, A.L.O.; Otake, A.H.; Rangel, M.C. Heat Shock Proteins Mediate Intercellular Communications within the Tumor Microenvironment through Extracellular Vesicles. Appl. Biosci. 2024, 3, 45-58. https://doi.org/10.3390/applbiosci3010003
Saito RF, Machado CML, Lomba ALO, Otake AH, Rangel MC. Heat Shock Proteins Mediate Intercellular Communications within the Tumor Microenvironment through Extracellular Vesicles. Applied Biosciences. 2024; 3(1):45-58. https://doi.org/10.3390/applbiosci3010003
Chicago/Turabian StyleSaito, Renata F., Camila Maria Longo Machado, Ana Luiza Oliveira Lomba, Andréia Hanada Otake, and Maria Cristina Rangel. 2024. "Heat Shock Proteins Mediate Intercellular Communications within the Tumor Microenvironment through Extracellular Vesicles" Applied Biosciences 3, no. 1: 45-58. https://doi.org/10.3390/applbiosci3010003