Prevalence of Escherichia coli Producing Extended Spectrum Beta-Lactamase (ESBL) Driven Septicaemia in Children Aged 0–2 Years in Two Districts Hospitals in Yaounde, Cameroon
Abstract
:1. Introduction
2. Results
2.1. E. coli Isolation from Blood Culture and ESBL Production
2.2. Resistance Profile of E. coli Strains to β-Lactams
2.3. E. coli Antibiotic Susceptibility Testing to Other Antibiotic Families
2.4. Univariate and Multivariate Analyses of Factors Associated with E. coli Producing ESBL
3. Discussion
4. Materials and Methods
4.1. Study Type and Location
4.2. Study Duration
4.3. Sample Collection
4.4. Bacteria Culture and Identification
4.5. Antibiotic Susceptibility Testing for ESBL Phenotype
4.6. Data Analysis and Interpretation
4.7. Ethical Considerations
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Factors | Total (N) | E. coli ESBL n (%) | E. coli Non-ESBL n (%) | p-Value |
---|---|---|---|---|
Admission (≥3 months) | ||||
No | 268 | 22 (8.21%) | 246 (91.79%) | |
Yes | 32 | 09 (28.13%) | 23 (71.88%) | 0.03 |
Use of Antibiotic | ||||
No | 230 | 17 (7.39%) | 213 (92.61%) | |
Yes | 70 | 14 (20%) | 56 (80%) | 0.02 |
Β-lactams (N = 70) | ||||
No | 04 | 1 (25%) | 3 (75%) | |
Yes | 66 | 12 (18.19%) | 48 (72.72%) | 0.003 |
Quinolone (N = 70) | ||||
No | 37 | 13 (35.14%) | 24 (64.87%) | |
Yes | 33 | 5 (15.15%) | 28 (84.85%) | 0.45 |
Aminosides (N = 70) | ||||
No | 10 | 2 (20%) | 8 (80%) | |
Yes | 60 | 12 (20%) | 48 (80%) | 0.24 |
Others | ||||
Bacterial infection | 1 | 0 (0.0%) | 1 (100%) | 0.99 |
Immunodeficiency | 233 | 14 (6.10%) | 219 (94%) | 0.0001 |
Blood Transfusion | 20 | 0 (0.0%) | 20 (100%) | 0.06 |
Factors | aOR | 95% CI | p-Value |
---|---|---|---|
Admission (≥3 months) | |||
No | 1 | ||
Yes | 2.94 | [0.97–8.91] | 0.06 |
On Antibiotic | |||
No | 1 | ||
Yes | 1.97 | [1.02–3.83] | 0.04 |
Β-lactams | |||
No | 1 | ||
Yes | 3.54 | [1.28–9.80] | 0.01 |
Aminosides | |||
No | 1 | ||
Yes | 1 | [1–1.33] | 0.41 |
Associated factors | |||
Immunodeficiency | 19.93 | [8.82–45.32] | 0.0001 |
Blood transfusion | 2.48 | [0.95–6.45] | 0.06 |
Bacterial infection | 3.45 | [1.19–2.95] | 0.99 |
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Djuikoue, C.I.; Djouela Djoulako, P.D.; Wouambo, R.K.; Lacmago, S.T.; Dayomo, A.; Kamga, H.G.; Thumamo Pokam, B.D.; Apalata, T. Prevalence of Escherichia coli Producing Extended Spectrum Beta-Lactamase (ESBL) Driven Septicaemia in Children Aged 0–2 Years in Two Districts Hospitals in Yaounde, Cameroon. Bacteria 2022, 1, 294-301. https://doi.org/10.3390/bacteria1040022
Djuikoue CI, Djouela Djoulako PD, Wouambo RK, Lacmago ST, Dayomo A, Kamga HG, Thumamo Pokam BD, Apalata T. Prevalence of Escherichia coli Producing Extended Spectrum Beta-Lactamase (ESBL) Driven Septicaemia in Children Aged 0–2 Years in Two Districts Hospitals in Yaounde, Cameroon. Bacteria. 2022; 1(4):294-301. https://doi.org/10.3390/bacteria1040022
Chicago/Turabian StyleDjuikoue, Cécile Ingrid, Paule Dana Djouela Djoulako, Rodrigue Kamga Wouambo, Suzie Titsamp Lacmago, Audrey Dayomo, Hortense Gonsu Kamga, Benjamin D. Thumamo Pokam, and Teke Apalata. 2022. "Prevalence of Escherichia coli Producing Extended Spectrum Beta-Lactamase (ESBL) Driven Septicaemia in Children Aged 0–2 Years in Two Districts Hospitals in Yaounde, Cameroon" Bacteria 1, no. 4: 294-301. https://doi.org/10.3390/bacteria1040022