Next Article in Journal
Functional and Evolutionary Characterization of the NSP6 Protein in SARS-CoV-2 Omicron Variants
Previous Article in Journal
Streamlined Production, Protection, and Purification of Enzyme Biocatalysts Using Virus-like Particles and a Cell-Free Protein Synthesis System
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
SynBio
Volume 3
Issue 1
10.3390/synbio3010006
synbio-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

The Role of the Sda Carbohydrate Antigen and That of Its Cognate Glycosyltransferase B4GALNT2 in Health and Disease

by
Martina Duca
,
Nadia Malagolini
and
Fabio Dall’Olio
*
Department of Medical and Surgical Sciences (DIMEC), University of Bologna, General Pathology Building, Via San Giacomo 14, 40126 Bologna, Italy
*
Author to whom correspondence should be addressed.
SynBio 2025, 3(1), 6; https://doi.org/10.3390/synbio3010006
Submission received: 4 June 2024 / Revised: 5 September 2024 / Accepted: 24 January 2025 / Published: 3 March 2025
Browse Figures
Review Reports Versions Notes

Abstract

The carbohydrate antigen Sda is expressed on the cells and secretions of the vast majority of Caucasians. The epitope is formed by a terminal GalNAc residue β4-linked to an α3-sialylated galactose. Different carbohydrate chains N- or O-linked to glycoproteins can be terminated by this epitope. The final step of Sda biosynthesis is catalyzed by the GalNAc transferase B4GALNT2. In this review, we discuss the multifaceted aspects of B4GALNT2/Sda in fertility and pregnancy, susceptibility to infectious diseases, cancer, chronic kidney diseases, and Duchenne muscular dystrophy. We show how multiple synthetic biology approaches have been adopted to investigate its role.
Keywords: Sda antigen; B4GALNT2; uromodulin; Tamm–Horsfall glycoproteins; influenza virus; Duchenne muscular dystrophy; synthetic biology Sda antigen; B4GALNT2; uromodulin; Tamm–Horsfall glycoproteins; influenza virus; Duchenne muscular dystrophy; synthetic biology

Share and Cite

MDPI and ACS Style

Duca, M.; Malagolini, N.; Dall’Olio, F. The Role of the Sda Carbohydrate Antigen and That of Its Cognate Glycosyltransferase B4GALNT2 in Health and Disease. SynBio 2025, 3, 6. https://doi.org/10.3390/synbio3010006

AMA Style

Duca M, Malagolini N, Dall’Olio F. The Role of the Sda Carbohydrate Antigen and That of Its Cognate Glycosyltransferase B4GALNT2 in Health and Disease. SynBio. 2025; 3(1):6. https://doi.org/10.3390/synbio3010006

Chicago/Turabian Style

Duca, Martina, Nadia Malagolini, and Fabio Dall’Olio. 2025. "The Role of the Sda Carbohydrate Antigen and That of Its Cognate Glycosyltransferase B4GALNT2 in Health and Disease" SynBio 3, no. 1: 6. https://doi.org/10.3390/synbio3010006

APA Style

Duca, M., Malagolini, N., & Dall’Olio, F. (2025). The Role of the Sda Carbohydrate Antigen and That of Its Cognate Glycosyltransferase B4GALNT2 in Health and Disease. SynBio, 3(1), 6. https://doi.org/10.3390/synbio3010006

Article Metrics

Back to TopTop