A Greater Reduction in Intrahepatic Fat Content after a Lifestyle Intervention Is Related to a Better Inflammatory and Oxidative Status †
by
, , , and
Margalida Monserrat Mesquida
1,2,3
,
Maria Magdalena Quetglas-Llabrés
1,2,3,
Sofía Montemayor
1,2,3,
Catalina Maria Mascaró
1,2,3,
Silvia Tejada
4,
Antoni Pons
1,2,3,
Josep A. Tur
1,2,3 and
Antoni Sureda
1,2,3,* 1
Research Group in Community Nutrition and Oxidative Stress, University of the Balearic Islands (IUNICS), 07122 Palma de Mallorca, Spain
2
Health Research Institute of Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain
3
CIBER Physiopathology of Obesity and Nutrition (CIBEROBN), Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain
4
Laboratory of Neurophysiology, University of the Balearic Islands (IUNICS), 07120 Palma de Mallorca, Spain
*
Author to whom correspondence should be addressed.
†
Presented at the 2nd International Electronic Conference on Nutrients, 15–31 March 2022; Available online: https://iecn2022.sciforum.net/ .
Biol. Life Sci. Forum 2022, 12(1), 9; https://doi.org/10.3390/IECN2022-12374
Published: 14 March 2022
(This article belongs to the Proceedings of The 2nd International Electronic Conference on Nutrients)
Abstract
:Non-alcoholic fatty liver disease (NAFLD) is a disease characterized by the excessive accumulation of lipids in the liver parenchyma. To date, there is no effective pharmacological treatment against NAFLD; however, lifestyle modifications, including physical activity and the adoption of healthy eating habits, are therapeutic approaches against this disease. The aim of this study was to evaluate the relationship between the improvement of the intrahepatic fat content (IFC) in patients with NAFLD and metabolic syndrome and biomarkers of oxidative stress and inflammation after 6 months of lifestyle intervention, which included a hypocaloric diet and the promotion of physical activity. Patients diagnosed with NAFLD (n = 60 adults; 40–60 years old) living in the Balearic Islands, Spain were classified in tertiles according to the improvement of IFC measured by Magnetic Resonance Imaging (MRI). Pro/antioxidant and inflammatory biomarkers were determined in plasma before and after the lifestyle intervention. The greatest improvement in IFC was directly related to a better cardiorespiratory fitness, determined with the Chester step test. Significant greater reductions in weight, body mass index, alanine aminotransferase and triglycerides were observed in the group with the greatest improvement in IFC compared to the one that improved the least after the intervention. No significant differences were detected in glucose, cholesterol and in aspartate aminotransferase. Similarly, the reduction in catalase plasma activity, irisin and cytokeratin 18 levels were significantly higher in the group with the highest degree of IFC reduction, whereas no differences were observed in superoxide dismutase activity and in malondialdehyde and protein carbonyl levels. A progressive decrease in reactive oxygen species production by peripheral blood mononuclear cells activated with lipopolysaccharide was observed after the lifestyle intervention. The present data show that a greater reduction in IFC is related to an improvement in pro/antioxidant and pro-inflammatory status and better cardiorespiratory fitness in NAFLD patients.
Supplementary Materials
The following are available online at https://www.mdpi.com/article/10.3390/IECN2022-12374/s1.
Author Contributions
Conceptualization, A.S., A.P. and J.A.T.; methodology, M.M.M., M.M.Q.-L., A.S., S.M., C.M.M. and S.T.; investigation, M.M.M., M.M.Q.-L., S.M., C.M.M. and S.T.; data curation, M.M.M. and M.M.Q.-L.; writing—original draft preparation, M.M.M. and M.M.Q.-L.; writing—review and editing, A.S. and J.A.T.; project administration, A.S. and J.A.T.; funding acquisition, J.A.T. All authors have read and agreed to the published version of the manuscript.
Funding
This research was funded by Fundació La Marató TV3 (Spain) with grant number 201630.10.
Institutional Review Board Statement
The study was conducted in accordance with the Declaration of Helsinki, and approved by the Ethics Committee of the Balearic Islands (IB 2251/14 PI).
Informed Consent Statement
Informed consent was obtained from all subjects involved in the study.
Data Availability Statement
Requestors wishing to access the trial data used in this study can make a request to the corresponding author.
Conflicts of Interest
The authors declare no conflict of interest.
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© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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MDPI and ACS Style
Mesquida, M.M.; Quetglas-Llabrés, M.M.; Montemayor, S.; Mascaró, C.M.; Tejada, S.; Pons, A.; Tur, J.A.; Sureda, A. A Greater Reduction in Intrahepatic Fat Content after a Lifestyle Intervention Is Related to a Better Inflammatory and Oxidative Status. Biol. Life Sci. Forum 2022, 12, 9. https://doi.org/10.3390/IECN2022-12374
AMA Style
Mesquida MM, Quetglas-Llabrés MM, Montemayor S, Mascaró CM, Tejada S, Pons A, Tur JA, Sureda A. A Greater Reduction in Intrahepatic Fat Content after a Lifestyle Intervention Is Related to a Better Inflammatory and Oxidative Status. Biology and Life Sciences Forum. 2022; 12(1):9. https://doi.org/10.3390/IECN2022-12374
Chicago/Turabian StyleMesquida, Margalida Monserrat, Maria Magdalena Quetglas-Llabrés, Sofía Montemayor, Catalina Maria Mascaró, Silvia Tejada, Antoni Pons, Josep A. Tur, and Antoni Sureda. 2022. "A Greater Reduction in Intrahepatic Fat Content after a Lifestyle Intervention Is Related to a Better Inflammatory and Oxidative Status" Biology and Life Sciences Forum 12, no. 1: 9. https://doi.org/10.3390/IECN2022-12374
