Do Exercise, Physical Activity, Dietetic, or Combined Interventions Improve Body Weight in New Kidney Transplant Recipients? A Narrative Systematic Review and Meta-Analysis
, Emily McBride 4, James Greenwood 5, Kate Bramham 2,6, Joseph Chilcot 7 and Sharlene A. Greenwood 1,2,3Round 1
Reviewer 1 Report
Interesting review and meta-analysis about the impact of exercise and physical activity on the outcome of kidney transplant patients based on a search on seven databases from 1985 to 2021.
This manuscript provides a lot of data on weight gain in patients after solid organ transplantation focussing on renal transplant recipients.
The influence of body weight in SOT was analyzed in different papers showing that weight gain increases the risk of death with a functioning kidney and that kidney transplant outcomes were adversely affected by obesity.
The reviewer did a very careful search of the literature and providde the results based on adequate statistical descriptions and methods.
It was of special interest to read this systematic review and meta-analysis about body weight and BMI within the first year after renal transplantation.
Author Response
Dear Reviewer 1,
Firstly, thank you for taking the time to read and review our manuscript.
We have made the following changes:
- Some grammatical errors were rectified
- A typo on the risk-of-bias of one study (in-text) was rectified
- The journal comments on referencing style and referencing list have been actioned with thanks.
We hope the manuscript is now fit for submission to Kidney and dialysis.
Please do let us know if there is anything else you require.
Many thanks,
Ellen Castle- on behalf of the co-authors listed.
Reviewer 2 Report
The current manuscript aims to examine the effect of exercise, physical activity, dietary and/or combined interventions on body weight and body mass index (BMI) within the first year of kidney transplantation. The authors did not find a significant impact of these interventions on clinical outcomes.
Overall, the manuscript is well written and methodology is adequate. I do not feel that the results of this meta-analysis could add something new in the literature since the studies analyzed are mainly characterized by small samples and limited power; moreover, a high heterogeneity of type and duration of interventions are described, limiting the impact of the current analysis.
The manuscript is suitable for publication according to the journal's priority
Author Response
Dear Reviewer 2,
Thank you kindly for your time reviewing our manuscript.
We have made the following changes:
- Some grammatical errors were rectified
- A typo on the risk-of-bias of one study (in-text) was rectified
- The journal comments on referencing style and referencing list have been actioned with thanks.
We hope the manuscript is now fit for submission to Kidney and dialysis.
Please do let us know if there is anything else you require.
Many thanks,
Ellen Castle- on behalf of the co-authors listed.
