Oxidative Stress in Antibiotic Toxic Optic Neuropathy Mimicking Acute LHON in a Patient with Exacerbation of Cystic Fibrosis
Abstract
:1. Introduction
2. Case Description
3. Discussion
4. Conclusions
Author Contributions
Funding
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Timeline | Clinical Progression |
---|---|
≥1 year prior to the symptoms’ onset | Combination antibiotic therapy with linezolid, azithromycin, ciprofloxacin, and tobramycin |
May/June 2020 | Hearing worsening; paresthesia in the hands, stomach and feet |
July 2020 | Blurry vision in both eyes |
24 July–3 August 2020: hospitalization | At admission: BCVA RE, 0.5; LE, 0.5. At discharge: BCVA RE, 0.3; LE, 0.3 Ishihara color plate score: RE, 9/21; LE, 13/21; no relative afferent pupillary defect; central scotomas in both eyes Hyperemic and swollen optic discs, tortuous and distended vessels Diagnostic tests: full blood panel, serology, head and cervical spine MRI, genetic testing, ENT examination, neurological, electrophysiology Discontinued ciprofloxacin and linezolid, started on supplemental therapy with biotin; Vitamins B1, B6, and B12; and idebenone |
September 2020 | Subjective improvement in visual acuity (as subsequently reported by the patient) |
October 2020 | Lung transplant |
18 January 2021: first outpatient follow-up | BCVA RE, 0.9; LE, 0.8 Ishihara plates: full Kinetic Goldmann perimetry: no scotoma Fundi normal, no visible disc edema |
4 February 2021 | Repeat electrophysiology: a slightly reduced PERG N95 wave in the RE; normal in the LE; significantly improved VEP signals from both eyes Macular OCT: GCL thinning in both eyes |
22 March 2021: second outpatient follow-up | BCVA RE, 1.0; LE, 1.0 Ishihara plates: full Automated static perimetry (Octopus, G2 TOP strategy) within normal limits |
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Kovač, L.; Volk, M.; Šuštar Habjan, M.; Hawlina, M. Oxidative Stress in Antibiotic Toxic Optic Neuropathy Mimicking Acute LHON in a Patient with Exacerbation of Cystic Fibrosis. Stresses 2023, 3, 387-396. https://doi.org/10.3390/stresses3010028
Kovač L, Volk M, Šuštar Habjan M, Hawlina M. Oxidative Stress in Antibiotic Toxic Optic Neuropathy Mimicking Acute LHON in a Patient with Exacerbation of Cystic Fibrosis. Stresses. 2023; 3(1):387-396. https://doi.org/10.3390/stresses3010028
Chicago/Turabian StyleKovač, Lea, Marija Volk, Maja Šuštar Habjan, and Marko Hawlina. 2023. "Oxidative Stress in Antibiotic Toxic Optic Neuropathy Mimicking Acute LHON in a Patient with Exacerbation of Cystic Fibrosis" Stresses 3, no. 1: 387-396. https://doi.org/10.3390/stresses3010028
APA StyleKovač, L., Volk, M., Šuštar Habjan, M., & Hawlina, M. (2023). Oxidative Stress in Antibiotic Toxic Optic Neuropathy Mimicking Acute LHON in a Patient with Exacerbation of Cystic Fibrosis. Stresses, 3(1), 387-396. https://doi.org/10.3390/stresses3010028