Extramedullary Hematopoiesis in Myelodysplastic Syndromes: A Systematic Literature Review
Abstract
:1. Introduction
2. Methods
3. Results and Discussion
Funding
Conflicts of Interest
Abbreviations
MDS | Myelodysplastic syndromes |
EMH | Extramedullary hematopoiesis |
References
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Variables 1 | All (n = 41) |
---|---|
Baseline characteristics | |
Age (years) | 70 (64–76) |
Male (%) | 27 (71.1) (n = 38) |
Hemoglobin (g/dL) | 8.2 (7.4–9.4) (n = 20) |
MDS subtype (%) | |
Ring sideroblasts | 11 (30.6) |
Excess blasts | 5 (12.2) |
EMH onset (%) | |
Symptomatic onset | 27 (65.9) |
After MDS diagnosis | 27 (73.0) (n = 37) |
Temporal relationship with prior growth factor use | 4 (9.8) |
EMH location (%) | |
Spleen and/or liver | 15 (36.6) |
Paravertebral region | 10 (24.4) |
Other sites 2 | 16 (39.0) |
EMH treatment (%) | (n = 38) |
Observation | 20 (52.6) |
Surgery | 14 (36.8) |
Radiation | 5 (13.2) |
MDS treatment (%) | (n = 27) |
Transfusion | 17 (63.0) |
Recombinant erythropoietin | 5 (18.5) |
Granulocyte-colony stimulating factor | 2 (7.4) |
Lenalidomide or thalidomide | 2 (7.4) |
Azacitidine | 1 (3.7) |
Outcomes | (n = 36) |
Death at last follow-up | 19 (52.8) |
Secondary acute myeloid leukemia | 4 (11.1) |
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Wang, C.; Shi, Y. Extramedullary Hematopoiesis in Myelodysplastic Syndromes: A Systematic Literature Review. Hemato 2022, 3, 569-573. https://doi.org/10.3390/hemato3030039
Wang C, Shi Y. Extramedullary Hematopoiesis in Myelodysplastic Syndromes: A Systematic Literature Review. Hemato. 2022; 3(3):569-573. https://doi.org/10.3390/hemato3030039
Chicago/Turabian StyleWang, Chen, and Yiyun Shi. 2022. "Extramedullary Hematopoiesis in Myelodysplastic Syndromes: A Systematic Literature Review" Hemato 3, no. 3: 569-573. https://doi.org/10.3390/hemato3030039