Immune Modulatory Effects of Ketogenic Diet in Different Disease Conditions
Abstract
:1. Introduction
2. Immune Modulation by Ketogenic Diet in Viral Infection
3. Ketogenic Diet Mediated Immune Regulation in Cancer
4. Ketogenic Diet Mediated Immune Regulation in Cardiovascular Diseases
5. Ketogenic Diet Mediated Immune Modulation in Central Nervous System Diseases
6. Keto Diet Complications:
7. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Type of Ketogenic Diet (KD) | Mechanism of Action | Conclusions/Effects | References |
---|---|---|---|
Medium-Chain Triglycerides (MCT) | Reduced Leukocyte Count | Anti-Tumor Effect | [79] |
Eucaloric Ketogenic Diet (EKD) | M1 Recruitment of Neutrophil and Platelets in Thrombo-Inflammation | Prevention of Cytokine Storm in COVID-19. | [80] |
Very Low Calorie Ketogenic Diet (VLCKD) | Altered Leukocyte Methylation | Obesity Prevention | [81] |
KD | Reduced WBC & Neutrophil Count | In Epilepsy, baseline immunosuppression does not worsen with KD. | [82] |
KD | Enhanced activity of Th1 cells | Promoted cellular immune function in a CT26 colon tumor allografts mouse model. | [33] |
KD | Suppression of Th1 & Th17 | Protection against autoinflammation (Central Nervous System). | [83] |
KD | Suppression of macrophages & neutrophils | Attenuation of autoinflammation (Muckle-Wells syndrome/ Gout) | [83] |
KD | Activation of protective γδ T cells and decreases myeloid cell subset | Ketogenesis-induced protection from mCoV-A59-driven inflammatory damage in aging. | [17] |
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Srivastava, S.; Pawar, V.A.; Tyagi, A.; Sharma, K.P.; Kumar, V.; Shukla, S.K. Immune Modulatory Effects of Ketogenic Diet in Different Disease Conditions. Immuno 2023, 3, 1-15. https://doi.org/10.3390/immuno3010001
Srivastava S, Pawar VA, Tyagi A, Sharma KP, Kumar V, Shukla SK. Immune Modulatory Effects of Ketogenic Diet in Different Disease Conditions. Immuno. 2023; 3(1):1-15. https://doi.org/10.3390/immuno3010001
Chicago/Turabian StyleSrivastava, Shivani, Vishakha Anand Pawar, Anuradha Tyagi, Kanti Prakash Sharma, Vinay Kumar, and Surendra Kumar Shukla. 2023. "Immune Modulatory Effects of Ketogenic Diet in Different Disease Conditions" Immuno 3, no. 1: 1-15. https://doi.org/10.3390/immuno3010001