The Role of Leukemia Inhibitory Factor in Counteracting the Immunopathology of Acute and Chronic Lung Inflammatory Diseases
Abstract
:1. Introduction
2. LIF Gene Regulation
3. LIF Protein Structure
Receptor Binding
4. LIF Downstream Pathways
4.1. STAT3
4.2. PI(3)Kinase Signaling
4.3. MAPK Signaling
5. Regulators of LIF Gene Expression
5.1. Hypoxia-Inducible Factors
5.2. IL-1β and IL-6
5.3. TGF-β
5.4. NF-κB RelA
5.5. P53
5.6. Activating Transcription Factor (AT) 3
5.7. TLR5
6. LIF Signaling in Pulmonary Diseases
6.1. Non-Small Cell Lung Cancer (NSCLC)
6.2. Acute Viral Lung Injury
6.3. Acute COPD Exacerbation
6.4. Acute Respiratory Distress Syndrome (ARDS)
6.5. Idiopathic Pulmonary Fibrosis (IPF)
6.6. Asthma
7. Immune System Interaction
7.1. Promoting Surfactant Synthesis
7.2. Acute Inflammatory Response Regulation
7.3. Innate Immunity Regulation
7.4. Adaptive Immunity Regulation
8. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Yu, H.; Zaveri, S.; Pillai, M.; Taluru, H.; Schaible, M.; Chaddha, S.; Ahmed, A.; Tfaili, S.; Geraghty, P. The Role of Leukemia Inhibitory Factor in Counteracting the Immunopathology of Acute and Chronic Lung Inflammatory Diseases. J. Respir. 2023, 3, 86-100. https://doi.org/10.3390/jor3020009
Yu H, Zaveri S, Pillai M, Taluru H, Schaible M, Chaddha S, Ahmed A, Tfaili S, Geraghty P. The Role of Leukemia Inhibitory Factor in Counteracting the Immunopathology of Acute and Chronic Lung Inflammatory Diseases. Journal of Respiration. 2023; 3(2):86-100. https://doi.org/10.3390/jor3020009
Chicago/Turabian StyleYu, Howard, Sahil Zaveri, Meshach Pillai, Harsha Taluru, Michael Schaible, Sahil Chaddha, Asad Ahmed, Said Tfaili, and Patrick Geraghty. 2023. "The Role of Leukemia Inhibitory Factor in Counteracting the Immunopathology of Acute and Chronic Lung Inflammatory Diseases" Journal of Respiration 3, no. 2: 86-100. https://doi.org/10.3390/jor3020009