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Review

Programmed Cell Death in SARS-CoV-2 Infection: A Short Review

1
Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA
2
Division of Pulmonary, Allergy, Critical Care Medicine, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Cesar A. Moran
J. Respir. 2021, 1(4), 223-228; https://doi.org/10.3390/jor1040021
Received: 16 August 2021 / Revised: 13 September 2021 / Accepted: 21 September 2021 / Published: 24 September 2021
(This article belongs to the Collection Feature Papers in Journal of Respiration)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the latest variant in the coronavirus family, causing COVID-19, has resulted in global pandemic since early 2020 leading to severe public health concern. So far, the pandemic has caused more than 200 million infections and 4 million deaths worldwide. Most of the studies are focused on developing prevention, intervention, and therapeutic strategies. However, underlying pathophysiology of the disease is important as well, which needs further attention. Cell death is one of the major causative mechanisms that leads to severe inflammation, and it is also an a posteriori consequence of the hyperinflammatory storm that renders poor prognosis of the disease. Substantial cell death has been reported in biopsy samples from post mortem patients. Among the distinct cell death pathways, apoptosis, the regulated programmed cell death plays an important role in the pathogenesis of the disease. Understanding the role of SARS-CoV-2 infection in apoptosis is critical to linearize the pathogenesis of the virus as well as the resultant disease, that may uncover novel therapeutic targets in treatment of COVID-19 patients. Here, we review the current progress on the underlying molecular mechanism(s) of SARS-CoV-2-induced apoptosis, not only at the level of the virus but also at its individual proteins. View Full-Text
Keywords: severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); apoptosis; ORF3a; ORF6a; NSP6; ORF7a; ORF8 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); apoptosis; ORF3a; ORF6a; NSP6; ORF7a; ORF8
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MDPI and ACS Style

Deshpande, R.; Zou, C. Programmed Cell Death in SARS-CoV-2 Infection: A Short Review. J. Respir. 2021, 1, 223-228. https://doi.org/10.3390/jor1040021

AMA Style

Deshpande R, Zou C. Programmed Cell Death in SARS-CoV-2 Infection: A Short Review. Journal of Respiration. 2021; 1(4):223-228. https://doi.org/10.3390/jor1040021

Chicago/Turabian Style

Deshpande, Rushikesh, and Chunbin Zou. 2021. "Programmed Cell Death in SARS-CoV-2 Infection: A Short Review" Journal of Respiration 1, no. 4: 223-228. https://doi.org/10.3390/jor1040021

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