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Volume 35
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10.3390/IECB2023-14570
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Proceeding Paper

Micro-Weighing Based Biosensor with Adaptive Interferometry †

by
Timofey Efimov
1,2,*,
Vadim Kumeiko
2,
Roman Romashko
1,2,
Mikhail Shmelev
2 and
Evgeni Rassolov
2
1
Institute of Automation and Control Processes of the Far Eastern Branch of the Russian Academy of Sciences, 690041 Vladivostok, Russia
2
School of Biomedicine, Far Eastern Federal University, 690922 Vladivostok, Russia
*
Author to whom correspondence should be addressed.
†
Presented at the 3rd International Electronic Conference on Biosensors, 8–21 May 2023; Available online: https://iecb2023.sciforum.net/.
Eng. Proc. 2023, 35(1), 10; https://doi.org/10.3390/IECB2023-14570
Published: 8 May 2023
(This article belongs to the Proceedings of The 3rd International Electronic Conference on Biosensors)
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Abstract

In this work, an adaptive holographic interferometer was implemented for the measurement of a micromechanical oscillator frequency. A silicon micro-cantilever mounted on a piezoquartz plate was used as the sensing element. Out-of-plane vibrations of the cantilever were excited using a sinusoidal electrical signal. The cantilever vibrations were measured with the adaptive interferometer using two waves coupling in a semi-insulating photorefractive CdTe:V crystal. In the experiment, the mass of absorbed molecules of bovine serum albumin (BSA) was measured at various concentrations of water solution. The biosensor demonstrated the ability to measure the concentration of BSA in water solutions with a concentration of 0.2 mg/mL. The result shows the possibility of using adaptive interferometry to detect the vibration of micromechanical sensors and the potential prospects for building biosensors based on them.
Keywords: biosensor; micromechanical oscillator; laser biosensor; holographic interferometry; mass sensor; adaptive interferometer biosensor; micromechanical oscillator; laser biosensor; holographic interferometry; mass sensor; adaptive interferometer

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MDPI and ACS Style

Efimov, T.; Kumeiko, V.; Romashko, R.; Shmelev, M.; Rassolov, E. Micro-Weighing Based Biosensor with Adaptive Interferometry. Eng. Proc. 2023, 35, 10. https://doi.org/10.3390/IECB2023-14570

AMA Style

Efimov T, Kumeiko V, Romashko R, Shmelev M, Rassolov E. Micro-Weighing Based Biosensor with Adaptive Interferometry. Engineering Proceedings. 2023; 35(1):10. https://doi.org/10.3390/IECB2023-14570

Chicago/Turabian Style

Efimov, Timofey, Vadim Kumeiko, Roman Romashko, Mikhail Shmelev, and Evgeni Rassolov. 2023. "Micro-Weighing Based Biosensor with Adaptive Interferometry" Engineering Proceedings 35, no. 1: 10. https://doi.org/10.3390/IECB2023-14570

APA Style

Efimov, T., Kumeiko, V., Romashko, R., Shmelev, M., & Rassolov, E. (2023). Micro-Weighing Based Biosensor with Adaptive Interferometry. Engineering Proceedings, 35(1), 10. https://doi.org/10.3390/IECB2023-14570

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