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Proceeding Paper

Rapid, Low-Cost Production of Multilayer Molds for PDMS Lab-on-Chip Devices †

by
Eldas M. Maesela
1,2,
Mandla Msimanga
2,
Masibulele Kakaza
1 and
Manfred R. Scriba
1,*
1
Future Production: Chemicals, Centre for Nano-Structured and Advanced Materials, Council for Scientific and Industrial Research, Pretoria 0184, South Africa
2
Department of Physics, Faculty of Science, Tshwane University of Technology, Pretoria 0083, South Africa
*
Author to whom correspondence should be addressed.
Presented at the Micro Manufacturing Convergence Conference, Stellenbosch, South Africa, 7–9 July 2024.
Eng. Proc. 2025, 109(1), 3; https://doi.org/10.3390/engproc2025109003
Published: 8 September 2025
(This article belongs to the Proceedings of Micro Manufacturing Convergence Conference)

Abstract

We present a simple, rapid and low-cost multi-layer mold fabrication method for production of polydimethylsiloxane (PDMS) lab-on-chip (LOC) devices. The new approach offers resource-strained researchers access to microfluidic lab-on-chip fabrication for medical diagnostics, food security and environmental monitoring applications. In this work, photomasks were designed on PowerPoint (2021) and printed on Pelikan transparency sheets using a Canon PIXMA iX6840 Inkjet printer. The photomasks were then tested for ultraviolet (UV) transmission and compared to the masks produced for circuit board manufacture. Another low-cost approach for the alignment of multi-exposure masks was also developed and tested by producing three-layer photoresist pyramid-like structures on silicon (Si) wafer using the soft lithography process.
Keywords: PDMS; lab-on-chip; photoresist; inkjet-printing; molds; lithography PDMS; lab-on-chip; photoresist; inkjet-printing; molds; lithography

Share and Cite

MDPI and ACS Style

Maesela, E.M.; Msimanga, M.; Kakaza, M.; Scriba, M.R. Rapid, Low-Cost Production of Multilayer Molds for PDMS Lab-on-Chip Devices. Eng. Proc. 2025, 109, 3. https://doi.org/10.3390/engproc2025109003

AMA Style

Maesela EM, Msimanga M, Kakaza M, Scriba MR. Rapid, Low-Cost Production of Multilayer Molds for PDMS Lab-on-Chip Devices. Engineering Proceedings. 2025; 109(1):3. https://doi.org/10.3390/engproc2025109003

Chicago/Turabian Style

Maesela, Eldas M., Mandla Msimanga, Masibulele Kakaza, and Manfred R. Scriba. 2025. "Rapid, Low-Cost Production of Multilayer Molds for PDMS Lab-on-Chip Devices" Engineering Proceedings 109, no. 1: 3. https://doi.org/10.3390/engproc2025109003

APA Style

Maesela, E. M., Msimanga, M., Kakaza, M., & Scriba, M. R. (2025). Rapid, Low-Cost Production of Multilayer Molds for PDMS Lab-on-Chip Devices. Engineering Proceedings, 109(1), 3. https://doi.org/10.3390/engproc2025109003

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