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Proceeding Paper

Synthesis of Heterocycles and Nucleosides Forming Higher—Order Structures †

1
Department of Medicinal Chemistry, University of Szeged, H-6720 Szeged, Hungary
2
MTA-SZTE Biomimetic Systems Research Group, Eötvös Loránd Research Network, H-6720 Szeged, Hungary
3
Institute of Physics, University of Pécs, H-7624 Pécs, Hungary
*
Author to whom correspondence should be addressed.
Presented at the 25th International Electronic Conference on Synthetic Organic Chemistry, 15–30 November 2021; Available online: https://ecsoc-25.sciforum.net/.
Academic Editor: Julio A. Seijas
Chem. Proc. 2022, 8(1), 4; https://doi.org/10.3390/ecsoc-25-11705
Published: 14 November 2021
Nucleic acid analogues play a multifaceted role in biology and materials science. Our efforts towards unveiling these roles led to xanthine derivatives that form higher–order structures with quadruplex-forming abilities. In this paper we present further modifications of the xanthine core resulting into 9-deaza and 8-aza-9-deaza heterocycles (pyrrolo[3,2-d]pyrimidines and pyrazolo[4,3-d]pyrimidines, respectively) that form tetrads and other higher–order structures. Additionally, the ring contraction of 5-fluoro-2′,3′-O-isopropylideneuridine gave rise to the formation of an imidazolidine-4-carboxylic acid nucleoside derivative. Our computational predictions forecasted that the latter derivative will form stable triads. View Full-Text
Keywords: heterocycles; pyrrolo[3,2-d]pyrimidines; pyrazolo[4,3-d]pyrimidines; nucleosides; higher–order structures heterocycles; pyrrolo[3,2-d]pyrimidines; pyrazolo[4,3-d]pyrimidines; nucleosides; higher–order structures
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MDPI and ACS Style

Váradi, Z.; Paragi, G.; Kupihár, Z.; Kele, Z.; Kovács, L. Synthesis of Heterocycles and Nucleosides Forming Higher—Order Structures. Chem. Proc. 2022, 8, 4. https://doi.org/10.3390/ecsoc-25-11705

AMA Style

Váradi Z, Paragi G, Kupihár Z, Kele Z, Kovács L. Synthesis of Heterocycles and Nucleosides Forming Higher—Order Structures. Chemistry Proceedings. 2022; 8(1):4. https://doi.org/10.3390/ecsoc-25-11705

Chicago/Turabian Style

Váradi, Zoltán, Gábor Paragi, Zoltán Kupihár, Zoltán Kele, and Lajos Kovács. 2022. "Synthesis of Heterocycles and Nucleosides Forming Higher—Order Structures" Chemistry Proceedings 8, no. 1: 4. https://doi.org/10.3390/ecsoc-25-11705

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