The Bitter Side of Sugar Consumption: A Mitochondrial Perspective on Diabetes Development
Round 1
Reviewer 1 Report
The review is well written. The authors have explained how dietary sugars alters mitochondrial function and promotes type-2 diabetes in adults and offspring.
It would be more informative if the authors could explain briefly about the impact of dietary sugars on mitochondrial dynamics (fission, fusion, mitophagy processes).
Minor comments:
Line 30 – 32: If there are any most recent demographic reports, please include those.
Line 113 – 114: Please include appropriate reference for the sentence “This has been vastly……”.
Line 159: Please include appropriate reference for the sentence “... and hepatic tissue of mice.”
Line 195 – 197: Please include reference for human studies.
Lines 214- 215: Please include suitable reference for human retinal pigment epithelial cells study.
Figure 1 legend: Please expand the following: GSH, GSSG, NDUFA, UQCRFS, Mt- ND4.
Figure 1: Gpx should be as GPx.
References 40 and 41: Same reference duplicated. Remove one.
Author Response
Please, see the attachment.
Author Response File: 
Author Response.pdf
Reviewer 2 Report
I thank the journal for giving me an opportunity to review the paper titled “The Bitter Side of Sugar Consumption: A Mitochondrial Perspective on Diabetes Development” by Diniz et al. This comprehensive review presents information on the link between the increased consumption of DS resulting in mitochondrial dysfunction associated with the development of T2D because of the accumulation of AGE products. The review also touches upon maternal high sugar diet and AGE consumption during gestation that can affect offspring later during their life with T2D. Overall, the review is excellent and very well-written. There are some minor points that the authors are requested to consider before this review can be accepted for publication.
• For section 2: a small flowchart as in suggested paper (PMID: 24843427, figure 2), to show a relation between mitochondrial dysfunction resulting in T2D may be helpful for the readers (authors can tweak it based on relevance to DS perhaps?).
• A clinical perspective on the topic is currently missing and it would be worthy to include a subsection on this, possibly before the conclusions and future perspective section. For example, please expand based on suggested references: PMID: 33969706, PMID: 30601700, PMID: 27444792, PMID: 33024433, PMID: 33804637
Author Response
Please, see the attachment.
Author Response File: Author Response.pdf
