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Review

From Exosome Glycobiology to Exosome Glycotechnology, the Role of Natural Occurring Polysaccharides

1
Department of Neuroscience and Brain Technologies (NBT), Istituto Italiano di Tecnologia (IIT), Via Morego, 16163 Genova, Italy
2
Institute for Microelectronics and Microsystems (IMM), CNR, Via Monteroni, 73100 Lecce, Italy
*
Author to whom correspondence should be addressed.
Equally contribution to the work.
Academic Editor: Cédric Delattre
Polysaccharides 2021, 2(2), 311-338; https://doi.org/10.3390/polysaccharides2020021
Received: 1 April 2021 / Revised: 27 April 2021 / Accepted: 27 April 2021 / Published: 7 May 2021
(This article belongs to the Collection Current Opinion in Polysaccharides)
Exosomes (EXOs) are nano-sized informative shuttles acting as endogenous mediators of cell-to-cell communication. Their innate ability to target specific cells and deliver functional cargo is recently claimed as a promising theranostic strategy. The glycan profile, actively involved in the EXO biogenesis, release, sorting and function, is highly cell type-specific and frequently altered in pathological conditions. Therefore, the modulation of EXO glyco-composition has recently been considered an attractive tool in the design of novel therapeutics. In addition to the available approaches involving conventional glyco-engineering, soft technology is becoming more and more attractive for better exploiting EXO glycan tasks and optimizing EXO delivery platforms. This review, first, explores the main functions of EXO glycans and associates the potential implications of the reported new findings across the nanomedicine applications. The state-of-the-art of the last decade concerning the role of natural polysaccharides—as targeting molecules and in 3D soft structure manufacture matrices—is then analysed and highlighted, as an advancing EXO biofunction toolkit. The promising results, integrating the biopolymers area to the EXO-based bio-nanofabrication and bio-nanotechnology field, lay the foundation for further investigation and offer a new perspective in drug delivery and personalized medicine progress. View Full-Text
Keywords: extracellular vesicle; exosome; nanocarrier; glycobiology; glycotechnology; polysaccharide-based hydrogel; targeted drug delivery; precision medicine; biomarker extracellular vesicle; exosome; nanocarrier; glycobiology; glycotechnology; polysaccharide-based hydrogel; targeted drug delivery; precision medicine; biomarker
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MDPI and ACS Style

Della Rosa, G.; Ruggeri, C.; Aloisi, A. From Exosome Glycobiology to Exosome Glycotechnology, the Role of Natural Occurring Polysaccharides. Polysaccharides 2021, 2, 311-338. https://doi.org/10.3390/polysaccharides2020021

AMA Style

Della Rosa G, Ruggeri C, Aloisi A. From Exosome Glycobiology to Exosome Glycotechnology, the Role of Natural Occurring Polysaccharides. Polysaccharides. 2021; 2(2):311-338. https://doi.org/10.3390/polysaccharides2020021

Chicago/Turabian Style

Della Rosa, Giulia, Clarissa Ruggeri, and Alessandra Aloisi. 2021. "From Exosome Glycobiology to Exosome Glycotechnology, the Role of Natural Occurring Polysaccharides" Polysaccharides 2, no. 2: 311-338. https://doi.org/10.3390/polysaccharides2020021

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