Role of Lipid Composition on the Mechanical and Biochemical Vulnerability of Myelin and Its Implications for Demyelinating Disorders
Round 1
Reviewer 1 Report
Comments and Suggestions for AuthorsThe manuscript is a review entitled “Role of Lipid Composition on the Mechanical and Biochemical Vulnerability of Myelin. Implications for Multiple Sclerosis and Other Demyelinating Disorders”.
The authors analyze the role of myelin lipid composition from both mechanical and biochemical perspectives. They discuss how lipid alterations may contribute to demyelinating diseases such as multiple sclerosis. Furthermore, the innovative concept of myelin as a dynamic energy reservoir is introduced, linking nutrition, metabolism, and myelin plasticity.
- The Introduction is extensive but could be more focused on the review’s objectives, avoiding repetition of well-known basic notions.
- Although recent studies (up to 2023) are cited, some sections lack a connection to the most up-to-date literature on lipid metabolism in multiple sclerosis (e.g., clinical studies or nutritional trials). This could be expanded.
- The existing figures (myelin schematics) are useful, but representations directly linking lipid composition with mechanical/biochemical vulnerability are missing. A summary diagram (mechanisms + related pathologies) would greatly improve readability.
- The image quality is poor, and Table 1 should be enlarged with a bigger font size.
Author Response
The manuscript is a review entitled “Role of Lipid Composition on the Mechanical and Biochemical Vulnerability of Myelin. Implications for Multiple Sclerosis and Other Demyelinating Disorders”.
The authors analyze the role of myelin lipid composition from both mechanical and biochemical perspectives. They discuss how lipid alterations may contribute to demyelinating diseases such as multiple sclerosis. Furthermore, the innovative concept of myelin as a dynamic energy reservoir is introduced, linking nutrition, metabolism, and myelin plasticity.
Comment 1.
The Introduction is extensive but could be more focused on the review’s objectives, avoiding repetition of well-known basic notions.
Response 1. We thank the reviewer for the observations. We have rewritten the introduction.
Comment 2.
Although recent studies (up to 2023) are cited, some sections lack a connection to the most up-to-date literature on lipid metabolism in multiple sclerosis (e.g., clinical studies or nutritional trials). This could be expanded.
Response 2. We thank the reviewer for the observations. We have rewritten - and expanded with recent references - Sections 4 and 5.
Comment 3.
The existing figures (myelin schematics) are useful, but representations directly linking lipid composition with mechanical/biochemical vulnerability are missing. A summary diagram (mechanisms + related pathologies) would greatly improve readability.
Response 3. We thank the reviewer for the observations. We added figure 3 in the Introduction Section.
Comment 4.
The image quality is poor, and Table 1 should be enlarged with a bigger font size.
Response 4. We thank the reviewer for the observations. We worked in the quality of images and table.
Reviewer 2 Report
Comments and Suggestions for AuthorsThis article summarizes the main lines of knowledge concerning the structure of myelin. Although the knowledge developed is generally well known, it is clearly summarized by the authors. Of interest lies in the last chapter summarizing the relatively new data concerning the capacity of myelin to synthesize energy by oxidation of fatty acids.
The article is well written, clear, comprehensive, a little long which is expected for the review of such a vast subject. We have no real criticism to make. The images are pretty and appropriate. Perhaps it would have been interesting to develop the last part and illustrate it, even if we still lack perspective on the role of this energy mechanism.
Author Response
This article summarizes the main lines of knowledge concerning the structure of myelin. Although the knowledge developed is generally well known, it is clearly summarized by the authors. Of interest lies in the last chapter summarizing the relatively new data concerning the capacity of myelin to synthesize energy by oxidation of fatty acids.
The article is well written, clear, comprehensive, a little long which is expected for the review of such a vast subject. We have no real criticism to make. The images are pretty and appropriate.
Comment 1.
Perhaps it would have been interesting to develop the last part and illustrate it, even if we still lack perspective on the role of this energy mechanism.
Response 1. We thank the reviewer for the observations. We have rewritten - and expanded with recent references - Sections 4 and 5.
