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Perspective

The Role of 3D Printing in Advancing Automated Manufacturing Systems: Opportunities and Challenges

by
Antreas Kantaros
*,
Christos Drosos
,
Michail Papoutsidakis
*,
Evangelos Pallis
and
Theodore Ganetsos
Department of Industrial Design and Production Engineering, University of West Attica, 12244 Athens, Greece
*
Authors to whom correspondence should be addressed.
Automation 2025, 6(2), 21; https://doi.org/10.3390/automation6020021
Submission received: 21 April 2025 / Revised: 19 May 2025 / Accepted: 22 May 2025 / Published: 26 May 2025

Abstract

:
The integration of 3D printing technologies in automated manufacturing systems marks a significant progression in the manufacturing industry, enabling elevated degrees of customization, efficiency, and sustainability. This paper explores the synergy between 3D printing and automation by conducting a critical literature review combined with case study analysis, focusing on their roles in enhancing production lines within the framework of Industry 4.0 and smart factories. Key opportunities presented by this integration include mass customization at scale, reduced material waste, and improved just-in-time manufacturing processes. However, challenges related to quality control, scalability, and workforce adaptation remain critical issues that require careful consideration. The study also examines the emerging role of hybrid manufacturing systems that combine additive and subtractive processes, alongside the growing need for standardized regulations and frameworks to ensure consistency and safety. Case studies are highlighted, showcasing real-world applications of automated 3D printing technologies and AI-driven print optimization techniques. In conclusion, this paper contributes to advancing the scholarly understanding of automated 3D printing by synthesizing technical, organizational, and regulatory insights and outlining future trajectories for sustainable and agile production ecosystems.

1. Introduction

Automation in manufacturing refers to the application of control systems, ma-chinery, and information technologies to manage industrial production processes with minimal or no human intervention [1]. Its evolution has been central to the advancement of modern industry, beginning with mechanical automation during the First Industrial Revolution and progressing through the introduction of electrical automation and computer numerical control (CNC) in the 20th century [2,3]. Today, automation encompasses a wide spectrum of technologies ranging from simple mechanized operations to highly sophisticated cyber–physical systems (CPSs) integrated within smart factories [4]. These systems rely on real-time data acquisition, sensor-driven feedback loops, and software-based process orchestration to improve accuracy, productivity, and consistency across the production lifecycle [5,6].
The implementation of automation in manufacturing has consistently aimed to achieve several core objectives: increasing operational efficiency, reducing production costs, improving product quality, and ensuring workplace safety [7]. Over time, these objectives have expanded to include responsiveness to market changes, customization capabilities, and environmental sustainability [8]. Key enablers of automation include programmable logic controllers (PLCs) [9,10], industrial robotics [11], automated guided vehicles (AGVs) [12], and enterprise resource planning (ERP) systems [13]. The integration of these technologies has led to the creation of highly automated manufacturing cells and entire production lines capable of executing complex tasks with high precision and minimal downtime. Notably, sectors such as automotive, electronics, and pharmaceuticals have extensively adopted automation to manage high-volume, high-precision manufacturing demands [14,15].
In the current era, automation is being transformed by the emergence of Industry X—a concept that fuses physical production with digital technologies including the Internet of Things (IoT), artificial intelligence (AI), and big data analytics [16,17,18,19,20,21,22,23]. These advances have given rise to smart manufacturing environments wherein machines can autonomously monitor, diagnose, and adapt to production conditions. Furthermore, digital twins [24,25,26], edge computing [27,28], and cloud-based control systems [29,30] now enable predictive maintenance and dynamic resource allocation, pushing the boundaries of traditional automation. In this context, the integration of additive manufacturing, or 3D printing, is increasingly recognized as a key enabler of further automation, offering new opportunities for decentralized production, on-demand fabrication, and design-driven manufacturing processes [31,32].
Three-dimensional (3D) printing, also known as additive manufacturing (AM), represents a fundamentally disruptive technologyin the sector of modern manufacturing [33]. Unlike traditional subtractive or formative methods, which rely on removing material from a block or shaping it through molds and dies, 3D printing constructs objects layer by layer directly from digital models [34,35]. This shift in manufacturing logic introduces elevated design freedom, eliminates the need for complex tooling, and allows for the creation of geometrically intricate structures that were previously unfeasible. As a result, 3D printing not only enables more agile prototyping but also unlocks new possibilities for functional part production across diverse industries such as aerospace, healthcare, automotive, and consumer goods [36].
The disruptive potential of 3D printing lies in its capacity to decentralize and de-materialize production. By digitizing the entire design-to-manufacture workflow, 3D printing allows manufacturers to localize production closer to the point of use, thus reducing supply chain dependencies and lead times [37]. Moreover, it facilitates on-demand manufacturing, minimizing excess inventory and allowing for hyper-customized products without significant cost penalties. These capabilities challenge conventional economies of scale and render the traditional mass production paradigm less dominant in favor of flexible, small-batch, or even single-unit production models [38]. As such, 3D printing disrupts not only the technical processes of manufacturing but also the economic and organizational structures that support them.
Furthermore, 3D printing fosters cross-disciplinary innovation by enabling rapid iteration and experimentation. Engineers, designers, and researchers can prototype and test concepts within hours, accelerating the product development cycle and enhancing innovation capacity [39,40]. In sectors like biomedicine, 3D bioprinting [41] opens new frontiers for tissue engineering [42] and patient-specific implants [43,44]. In construction [44,45] and architecture [46,47], large-scale additive manufacturing technologies enable novel building methods and sustainable material usage [48]. As the technology matures and expands into new material domains—such as ceramics [49], metal [50,51], composites [52,53] and even smart materials [54,55]—it is believed not only to supplement traditional manufacturing, but to play a major role in the evolution of digital and automated production ecosystems.
This study employs a combined approach of critical literature review and case study analysis to explore the synergy between 3D printing and automated manufacturing systems. Relevant literature from 2015 to 2025 was reviewed, sourced from databases such as Scopus and Web of Science, using keywords like ‘3D printing’, ‘automated manufacturing’, and ‘Industry 4.0’. Additionally, real-world case studies were analyzed, such as those from Dabbagh et al. [56] and Melton Machine & Control Co. [57], to identify practical applications and challenges. By synthesizing insights from these sources, key opportunities and challenges were derived, which are discussed in detail in the following sections.
In this context, the growing synergy of 3D printing and automation technologies plays an immense role in advancing manufacturing systems. Its integration into automated processes provides both strategic and operational advantages as additive manufacturing evolves from a prototyping tool into a feasible production approach [58] By means of a critical analysis of the dynamic interaction between 3D printing and automation, this study adds to the academic conversation by considering not just their technical convergence but also their consequences for the evolution of smart, responsive, and sustainable manufacturing ecosystems. By contextualizing automated 3D printing within Industry X, the study provides a structured evaluation of how these technologies collectively enable mass customization, reduce resource consumption, enhance manufacturing agility, and support decentralized production models. Beyond mapping these opportunities, the work offers an in-depth discussion of the technical, organizational, and regulatory challenges involved in embedding 3D printing into complex automated environments, including concerns related to quality assurance, scalability, and system interoperability. Through its comprehensive and analytical approach, this study contributes to a greater understanding of 3D printing’s transformative impact on automated manufacturing, positioning its findings to inform both academic research and industrial practice.

2. Three-Dimensional Printing as a Catalyst in Automated Manufacturing

Within the framework of Industry 4.0 and its current evolution to Industry X, which signifies the integration of cyber–physical systems, the Internet of Things (IoT), cloud computing, and artificial intelligence into industrial environments, 3D printing assumes an important role as both a manufacturing enabler and a digital catalyst [59]. Its inherently digital nature aligns seamlessly with the data-driven, interconnected modus operandi of smart factories, where production is no longer confined to rigid assembly lines but becomes adaptive, modular, and reconfigurable. Three-Dimensional printers can be deployed as autonomous production units that receive design files directly from centralized or decentralized digital systems, allowing for rapid, on-demand fabrication [60]. When networked within an Industry 4.0 environment, these systems can be monitored, diagnosed, and optimized remotely, contributing to the broader goals of self-organizing production lines, predictive maintenance, and real-time responsiveness to market demands [61,62].
Moreover, the additive nature of 3D printing supports several core elements of smart manufacturing, such as mass customization, material efficiency, and minimal human intervention. By eliminating the need for tooling and enabling near-zero waste production, 3D printing complements sustainable manufacturing objectives often associated with Industry 4.0 [63]. Its compatibility with machine learning algorithms and sensor-based feedback systems further enables intelligent process control, where parameters such as temperature, layer adhesion, or print quality can be automatically adjusted in real-time. This creates a closed-loop manufacturing environment where quality assurance and process optimization are increasingly automated [64]. In this context, 3D printing is not just a tool for fabrication but an enabling technology within a broader intelligent manufacturing ecosystem—capable of interfacing with robotic arms, automated storage and retrieval systems, and enterprise resource planning software to drive holistic operational efficiency and innovation [65].
The incorporation of additive manufacturing technologies into automated production lines introduces unprecedented process flexibility and digital continuity. One of the principal advantages lies in the seamless transition from digital design to physical realization without the need for intermediate tooling, molds, or die-specific hardware. This tool-less manufacturing capability facilitates rapid product iteration, shortens development cycles, and supports the economic feasibility of low-volume and highly customized production runs [66]. From a systems engineering perspective, the programmability of 3D printing aligns with reconfigurable manufacturing systems (RMSs), allowing production assets to be rapidly redeployed across different product lines with minimal reconfiguration time [67]. This enhances the responsiveness of production systems to fluctuating market demands and reduces lead times, especially in high-mix, low-volume manufacturing environments.
From an operational standpoint, the automation of 3D printing work-flows—through the integration of robotic systems, sensor-based process monitoring, and AI-driven control algorithms—enables continuous, unattended operation, often referred to as “lights-out” manufacturing [68,69,70,71,72]. This minimizes labor dependency and increases machine utilization rates, which are critical metrics in industrial productivity. Automated post-processing, part removal, and in-line quality assurance systems further contribute to reducing process variability and ensuring repeatability, which are essential for meeting stringent industrial standards [73,74]. Moreover, additive manufacturing enables the consolidation of complex assemblies into monolithic components, thereby reducing the number of parts, eliminating assembly steps, and simplifying bill-of-material (BOM) structures [75,76]. This has downstream effects on logistics, inventory management, and maintenance, enhancing overall supply chain efficiency and system robustness [77].
In addition to performance and economic considerations, the integration of 3D printing into automated production lines supports broader sustainability objectives [78]. Additive manufacturing is inherently material-efficient, as it constructs components layer by layer using only the material required for the final geometry, thereby significantly reducing scrap rates compared to traditional subtractive or formative processes [79]. When embedded within automated workflows, this efficiency is further enhanced through real-time monitoring of material usage and adaptive control strategies that optimize deposition parameters to minimize waste [80]. Furthermore, closed-loop material recovery systems and the use of recyclable feedstocks can be readily integrated into the workflow, aligning production with circular economy principles. These attributes render automated additive manufacturing not only a technically advanced solution but also a strategically sustainable one, contributing to the long-term viability of industrial operations in an era of increasing environmental and regulatory constraints [81]. Figure 1 depicts elements of this synergy.
The integration of 3D printing into automated manufacturing systems has been extensively explored in scientific literature, highlighting its transformative impact across various industries. One notable published literature case study by Dabbagh et.al. involves the application of machine learning algorithms to optimize extrusion-based 3D printing processes [82]. Researchers have developed systems that employ machine learning to predict and adjust printing parameters, such as temperature and pressure, to enhance print quality and reduce material waste. This approach not only streamlines the manufacturing process but also enables real-time adjustments, leading to improved efficiency and consistency in production outcomes.
As mentioned before, the use of artificial intelligence (AI) has been instrumental in accelerating the development of novel 3D printing formulations. A published literature study by Elbadawi et al. demonstrated the application of conditional generative adversarial networks (cGANs) to create new formulations for fused deposition modeling (FDM) printing [83]. By training on a dataset of existing formulations, the AI system was able to generate innovative material compositions, some of which were successfully fabricated using FDM printers. This depicts the potential of AI to expedite the formulation development process, reducing reliance on traditional trial-and-error methods and fostering innovation in material science.
Furthermore, the implementation of case-based reasoning systems in 3D printing has shown promise in enhancing print quality. In a published literature study, Yang developed AI systems that retrieve and adapt solutions from a case library to address specific printing challenges [84]. By inputting desired print characteristics, users can obtain optimized printing parameters based on prior cases, thereby improving the quality of printed objects and reducing the need for extensive manual adjustments. This approach underscores the role of AI in facilitating knowledge transfer and continuous improvement within automated 3D printing environments.
In another instance, Melton Machine & Control Company (MMCC), an industrial automation provider, utilized selective laser sintering (SLS) 3D printing to develop custom switch housings for welding fixtures [85]. This innovative action addressed challenges related to high temperatures and spatter in welding environments, resulting in enhanced durability and performance of the fixtures. The successful implementation of this solution underscores the potential of 3D printing to optimize manufacturing processes and improve product quality.
In another published literature case study, this time involving PrintMax Solutions, Lengyel demonstrated how AI-driven automation streamlined operations, resulting in a 40% reduction in production times and a 30% decrease in print job errors [86]. The AI system facilitated personalized customer interactions, optimized scheduling, and effi-cient inventory management, leading to significant cost savings and enhanced customer satisfaction. This example highlights the transformative impact of AI in automating end-to-end print services within the manufacturing sector.
Furthermore, advancements in robotic systems have addressed challenges in post-processing 3D-printed parts. A relative published literature case study by Nguyen et.al. introduced a robotic system for automated decaking, effectively removing residual powder from 3D-printed components [87]. By integrating deep learning for 3D perception, motion planning, and force control, the system demonstrated efficiency and speed in decaking processes, supporting the scalability of 3D printing in mass manufacturing. This development exemplifies the role of robotics and AI in enhancing the post-processing stages of additive manufacturing.
These case studies collectively illustrate the substantial benefits of integrating 3D printing and artificial intelligence (AI) into automated manufacturing systems, including improved product quality, enhanced operational efficiency, and significant cost reductions. As these technologies continue to mature, their synergistic application is expected to further drive innovation, agility, and sustainability across manufacturing processes.
Table 1 presents a curated compilation of case studies that exemplify the conver-gence of 3D printing, automation, and AI within diverse industrial contexts. The selec-tion of these case studies was guided by a structured set of criteria: (i) relevance to the core themes of the study—namely, automation, additive manufacturing, and AI integration; (ii) demonstration of measurable or documented impact on production efficiency, customization, or quality control; (iii) representation of diverse sectors (e.g., automotive, healthcare, consumer goods) to showcase cross-industry applicability; (iv) inclusion of both academic and industrial sources to balance theoretical insights with real-world implementation; and (v) technological maturity, ensuring that selected cases reflect scalable or operationally viable solutions rather than purely experimental prototypes.
Each case was drawn from reputable peer-reviewed publications or validated in-dustry reports, ensuring credibility and technical robustness. Collectively, these exam-ples underscore the transformative potential of combining 3D printing with automation and AI to reshape modern production paradigms and support the evolution toward smart, adaptive manufacturing ecosystems.

3. Opportunities in Automated 3D Printing

3.1. Methodological Approach

This study adopts a mixed-methods approach, combining a critical literature review with a qualitative case study analysis to examine the integration of 3D printing and automation within manufacturing systems. Data collection was conducted through a systematic review of peer-reviewed academic literature, industrial reports, and technology white papers published between 2021 and 2025. Databases such as Scopus, Web of Science, IEEE Xplore, and ScienceDirect were queried using key terms including “3D printing”, “automation”, “Industry 4.0”, “AI in manufacturing”, and “smart factories”. After filtering for relevance, originality, and citation impact, over 200 publications were analyzed. Case studies were then selected based on five guiding criteria: (i) alignment with the study’s focus on the synergy between 3D printing, automation, and AI; (ii) evidence of measurable or reported impact on manufacturing efficiency, product quality, or operational performance; (iii) representation of diverse industrial sectors (e.g., aerospace, automotive, healthcare); (iv) technological maturity, i.e., systems that are beyond the conceptual stage and show real-world implementation or commercial potential; and (v) credibility and data richness, prioritizing sources with robust methodological foundations or detailed industrial documentation. Thematic analysis was employed to interpret findings, categorize common patterns, and identify both enabling factors and persistent challenges. This interpretive framework allowed for a triangulated synthesis, combining theoretical insights from the literature with empirical evidence from case studies, thereby ensuring a thorough and analytically sound foundation for the discussion of opportunities and limitations in automated 3D printing ecosystems.

3.2. Case Studies of 3D Printing and Automation Integration

In this context, mass customization represents one of the most transformative aspects of modern manufacturing, allowing businesses to provide tailored products to consumers without sacrificing efficiency or scalability [88,89]. The integration of automation and 3D printing plays a crucial role in enabling mass customization by allowing for highly individualized production while maintaining the speed and cost-effectiveness associated with traditional manufacturing techniques [90]. Automation facilitates the seamless integration of customer-specific data into the production process, enabling the creation of products that are personalized in design, size, or function [91,92]. In the context of 3D printing, this can be achieved through the use of sophisticated design software and AI-driven systems that allow for real-time adjustments and rapid prototyping [93,94]. These capabilities enable manufacturers to deliver customized goods in various industries, from footwear to healthcare products, all while keeping production runs highly efficient and cost-effective.
The ability to offer mass customization is further enhanced by the flexibility inherent in 3D printing technology [95]. Unlike traditional manufacturing methods, which often rely on costly molds or tools for each product variation, 3D printing operates through a digital file that can be easily modified to accommodate different specifications [96]. This eliminates the need for expensive retooling between production batches, making it possible to produce a wide range of product variants without significantly increasing production costs. Additionally, automated systems that integrate 3D printing can adjust the manufacturing process dynamically to accommodate different customer requirements, providing a level of personalization that is difficult to achieve with conventional methods [97]. This integration of 3D printing and automation allows for the mass production of customized goods, such as orthopedic implants, automotive components, and even clothing, all of which can be manufactured to meet specific consumer preferences or medical needs without compromising production efficiency [98].
One of the most compelling examples of mass customization through automation is the use of 3D printing in the fashion industry. Companies like Adidas and Nike have already implemented additive manufacturing to create customized footwear that is tailored to individual foot shapes and performance needs. By using data from 3D scans of consumers’ feet, these companies are able to create shoes that offer improved comfort and functionality while minimizing waste [99]. This approach not only enhances the consumer experience by offering personalized products but also contributes to sustainability by reducing the need for excess inventory and decreasing material waste.
In the context of adopting the cutting-edge Direct Injection Process (DIP) [100], Figure 2 shows ECCO’s incorporation of Stratasys Origin One 3D printing technology into their shoe manufacturing process. ECCO has greatly limited mould fabrication time and expenses as compared to conventional CNC-machined aluminium moulds by using 3D-printed moulds By Stratasys (Eden Prairie, MN, USA) and shoe lasts made with Henkel (Düsseldorf, Germany) Loctite photopolymer resins. This development speeds up product creation cycles and lets conceptual shoe designs be quickly prototyped and tested in early stages, hence enabling more iterative design processes. In this case, the use of additive manufacturing shows the possibility for further automation and efficiency in shoemaking, therefore complementing the study’s exploration of integrating 3D printing technologies into automated manufacturing systems.

3.3. Opportunities Identified Across Case Studies

Beyond consumer goods, the healthcare industry also stands to benefit from mass customization through automation. For example, 3D-printed medical devices, including custom prosthetics and implants, can be made to fit the unique anatomy of individual patients, providing a more effective and personalized solution [101,102]. The ability to customize products at scale through automation, enabled by 3D printing, opens up new possibilities for industries to offer individualized solutions without sacrificing efficiency or quality [103,104].
The integration of automation with 3D printing has significant potential to reduce material waste and enhance the sustainability of production processes. Traditional manufacturing methods, such as injection molding and CNC machining, typically involve subtracting material from a larger block or creating excess parts that are discarded due to imperfections or overproduction [105]. In contrast, 3D printing, particularly when combined with automated systems, is an additive process that only uses the material needed to create a part, significantly reducing waste [106]. Automation further amplifies this benefit by optimizing the printing process in real-time, ensuring that the amount of material used is closely aligned with the specifications required for the final product [107,108]. These systems can adjust print parameters such as speed, layer thickness, and material flow to minimize material consumption, which is especially important when working with expensive or environmentally sensitive materials [109,110]. As industries continue to focus on sustainability, integrating 3D printing and automation presents a solution for reducing the environmental footprint of manufacturing.
In addition to material waste reduction, automation enables more efficient material usage through the integration of real-time monitoring and feedback systems. These systems can detect any anomalies in the printing process, such as inconsistencies in material deposition or layer bonding, and make adjustments to ensure that only the necessary amount of material is used [111]. This not only leads to less waste but also improves the quality of the final product by ensuring that it meets the required specifications. Furthermore, automated systems equipped with artificial intelligence can predict and detect any potential issues before they result in waste, providing opportunities for further optimization [112]. These capabilities are particularly important in industries where high-performance materials are used, such as aerospace or medical device manufacturing, where minimizing waste is critical both for cost efficiency and regulatory compliance [113,114,115,116,117]. By integrating AI-driven optimization algorithms into the 3D printing process, manufacturers can reduce excess material consumption, improve overall resource efficiency, and contribute to a more sustainable manufacturing model.
The environmental benefits of integrating 3D printing with automation are also evident in the reduction of energy consumption. Traditional manufacturing methods often require significant energy inputs, particularly in the use of heavy machinery and high temperatures [118]. By contrast, 3D printing processes generally require less energy, especially when combined with automated systems that optimize energy usage by adjusting printing speeds and material flows. Automated 3D printing systems can further minimize energy waste by continuously analyzing and adjusting operational parameters, such as print speed and temperature, to ensure the process remains as energy-efficient as possible [119]. This efficiency is particularly advantageous in industries with high energy costs or those striving to meet sustainability goals. Moreover, the ability to produce components on demand, without the need for large-scale production runs or extensive inventories, reduces the environmental impact of logistics and shipping. Thus, the integration of automation and 3D printing therefore not only contributes to the reduction in material waste but also enhances overall sustainability by improving resource utilization and minimizing energy consumption throughout the production cycle [120].
The integration of 3D printing with automation has the potential to revolutionize just-in-time (JIT) manufacturing and digital inventory models, offering significant advantages in terms of efficiency, cost savings, and flexibility [121]. Just-in-time manufacturing is a strategy aimed at reducing inventory costs by producing items only when they are needed, rather than maintaining large stockpiles of finished goods or raw materials [122]. Traditional manufacturing methods face challenges in implementing JIT efficiently, particularly when complex parts or customizations are required [123,124,125]. However, 3D printing, when combined with automated production lines, allows for on-demand production of parts and products, eliminating the need for large inventories [126,127]. Automated systems can quickly adjust production schedules based on real-time demand, enabling manufacturers to respond flexibly to shifts in consumer preferences or supply chain disruptions [128,129]. This capability is particularly valuable in industries with high variability in demand, such as automotive or consumer electronics, where quick responses to market changes are critical.
Moreover, the integration of automation with 3D printing helps optimize the digital inventory model, which relies on the use of digital designs stored in cloud-based systems to facilitate on-demand manufacturing [130]. Rather than relying on physical inventory, manufacturers can store digital files of components and products that can be printed as needed [131]. This eliminates the costs and space associated with maintaining physical stock, while also reducing the risk of overproduction or obsolescence. The automation of this process allows for greater accuracy in fulfilling orders and ensures that components are manufactured precisely to specifications, which can be particularly important for industries that rely on complex, high-precision parts, such as aerospace or medical devices [132]. With automated systems handling everything from material selection to part assembly, manufacturers can achieve faster turnaround times, reduce lead times, and streamline production workflows, all while maintaining a high degree of customization and quality control [133].
Additionally, automation in 3D printing enhances the ability to implement a more dynamic supply chain strategy, where parts can be produced locally, reducing the need for extensive global logistics networks [134]. This is especially beneficial in industries where supply chain disruptions or geopolitical uncertainties may affect the timely de-livery of parts or raw materials. By producing parts on-site or closer to the point of use, manufacturers can minimize the risks associated with long lead times and transportation delays [135]. This model also enables the use of localized materials, further reducing the environmental impact of transportation and contributing to sustainability goals [136,137]. Furthermore, 3D printing combined with automation facilitates the creation of decentralized manufacturing networks, where production can be distributed across various locations, making supply chains more resilient and adaptive to changing market conditions [138,139]. As a result, the integration of 3D printing and automation supports the development of agile, responsive manufacturing systems that can optimize inventory management, reduce costs, and improve overall supply chain efficiency [140].
Table 2, summarizes the primary advantages of combining 3D printing with automation, highlighting their impact on production processes, sustainability, and customization. It includes examples of industries and applications where these benefits are most effectively realized.

4. Challenges and Limitations

At this level, the key challenges associated with the integration of 3D printing into automated manufacturing systems are examined. Despite the promising advantages of combining additive manufacturing with automation, several technical, operational, and organizational hurdles must be addressed to fully capitalize on these synergies [141]. Among the primary challenges are ensuring consistent quality control and repeatability of 3D-printed parts, which is critical for maintaining high manufacturing standards [142]. Additionally, concerns related to the scalability of 3D printing processes in comparison to conventional manufacturing methods need to be evaluated, particularly regarding production speed and throughput [143]. Another significant challenge lies in ensuring compatibility between 3D printing technologies and existing automated systems, such as robotics and CNC machines [144,145]. Furthermore, the adaptation of the workforce to new technological paradigms, especially in terms of human oversight and interaction with AI-driven systems, is essential for optimizing the efficiency of these integrated systems. This chapter critically explores these challenges, providing an in-depth analysis of the complexities involved in the seamless integration of 3D printing with automation, and discusses potential strategies for overcoming these barriers. Figure 3 depicts the aforementioned challenges.

4.1. Quality Control and Repeatability

One of the primary challenges in integrating 3D printing with automated manufacturing systems is ensuring consistent quality control and repeatability of the printed parts. Unlike traditional manufacturing methods, which benefit from established processes and standardized equipment, 3D printing is inherently more variable due to factors such as material properties, print layer adhesion, and machine calibration [146]. These variables can lead to inconsistencies in the quality of the printed parts, which is a significant concern in industries where high precision and reliability are paramount, such as aerospace, automotive, and medical device manufacturing [147]. While advancements in 3D printing technologies, such as improved hardware and material formulations, have reduced some of these variations, ensuring that parts meet stringent quality standards on a consistent basis remains a challenge [148]. Additionally, the complexity of the printing process, including factors like print speed, temperature fluctuations, and material extrusion rates, can further exacerbate the difficulty in achieving repeatable results, which are essential for large-scale production [149].
The complexity of achieving consistent quality is further compounded by the lack of universally accepted standards for 3D printed parts. Unlike traditional manufacturing processes, where quality control protocols are well established and widely adopted, 3D printing is still evolving, with different methods (e.g., FDM, SLA, SLS) and materials (e.g., plastics, metals, ceramics) often requiring distinct quality assurance practices [150]. The lack of standardized testing methods for 3D-printed components complicates the validation of their mechanical properties, such as tensile strength, fatigue resistance, and thermal stability [151]. As a result, manufacturers are often left to develop in-house protocols for quality assurance, which can be time-consuming and costly [152]. Furthermore, the integration of 3D printing with automated production lines necessitates the continuous monitoring of quality during the printing process, which requires advanced sensors and real-time data analytics to detect and correct defects before they impact the final product [153]. This additional layer of complexity presents a significant challenge in ensuring that automated 3D printing systems can produce consistent and high-quality outputs on a large scale.
Addressing quality control and repeatability in automated 3D printing systems also involves overcoming the challenge of process optimization [154]. Traditional manufacturing techniques benefit from highly refined and optimized processes that have been developed and tested over time, whereas 3D printing processes are still being optimized for specific applications and materials [155]. Factors such as print speed, layer height, and material deposition rate can significantly influence the final part quality, and finding the optimal parameters for each application requires extensive testing and fine-tuning [156]. Moreover, the integration of automation into the 3D printing workflow adds another layer of complexity, as automated systems must be able to dynamically adjust printing parameters in real time based on feedback from the process [157]. While machine learning algorithms and artificial intelligence are being explored to assist in this optimization, the need for continuous refinement of both the hardware and software used in automated 3D printing systems remains a major challenge [158]. Overcoming these obstacles requires not only advancements in 3D printing technology but also the development of robust quality control frameworks that can ensure the repeatability and reliability of parts produced in automated environments.

4.2. Speed and Scalability Constraints

Another significant challenge in integrating 3D printing with automated manufacturing systems is addressing scalability concerns, particularly when compared to traditional manufacturing processes [159]. While 3D printing offers unparalleled flexibility and customization, it often struggles to match the speed and throughput of conventional automated systems such as injection molding, CNC machining, or stamping [160]. Traditional manufacturing methods, especially those used in mass production environments, are highly optimized for high-volume output, with machines capable of producing thousands or even millions of identical parts per day. In contrast, 3D printing, while capable of producing complex geometries and customized parts, typically operates at a slower pace, particularly when producing large quantities of items. This disparity in production speed poses a significant challenge when attempting to scale 3D printing for industrial applications, especially in sectors that rely on high-volume production, such as automotive or consumer electronics [161].
Moreover, the scalability issue is further compounded by the limitations inherent in current 3D printing technologies. The process of additive manufacturing, particularly in methods like fused deposition modeling (FDM) and stereolithography (SLA), is inherently slower than traditional manufacturing techniques due to the step-by-step deposition of material layer-by-layer [162]. While advancements in multi-material printing, high-speed 3D printers, and parallel printing configurations are beginning to address these speed limitations, they still face challenges in achieving the production rates required for large-scale manufacturing [163,164]. Furthermore, the time-consuming nature of post-processing steps, such as curing, finishing, and assembly, often required after 3D printing, adds additional time to the overall production process [165]. In automated systems, these post-processing tasks can be further complicated by the need for integration with robotic systems, requiring additional synchronization and optimization to ensure efficiency. As a result, achieving scalability in 3D printing requires significant technological advancements not only in the printing process itself but also in ancillary systems that support post-processing and quality control.
To overcome these scalability challenges, it is crucial to focus on optimizing the entire production workflow rather than just the 3D printing process itself. One potential solution lies in the integration of hybrid manufacturing systems, which combine additive and subtractive manufacturing techniques to take advantage of the strengths of both methods [166]. For example, 3D printing can be used to produce complex or customized parts, while traditional manufacturing techniques can be used for high-volume production of simpler components. Hybrid systems can also facilitate faster post-processing by incorporating automated finishing technologies, such as robotic polishing or surface treatment, which can reduce the time required for part preparation and assembly [167]. Additionally, the development of multi-printer systems that operate in parallel or synchronized production lines could further enhance scalability, enabling manufacturers to meet the high production demands typical of traditional manufacturing industries [168]. However, achieving true scalability in automated 3D printing systems will require not only technological innovations but also the development of effective strategies for integrating these systems into existing production lines, ensuring that they can operate at the required speed and efficiency for large-scale manufacturing.

4.3. System Integration Challenges

A further challenge in integrating 3D printing with automated manufacturing systems is ensuring compatibility with existing workflows, particularly with robotic and CNC-based automation systems [169]. While 3D printing has the potential to significantly enhance production flexibility, its integration into established manufacturing systems that rely on well-established automation technologies presents several technical hurdles. Robotic arms, CNC machines, and other automated systems are typically designed for subtractive manufacturing processes, where material is removed from a solid block to create a part. In contrast, 3D printing is an additive process, where material is deposited layer by layer. This fundamental difference in manufacturing principles requires modifications to the design and operation of existing automated systems to accommodate the unique requirements of additive manufacturing, such as precise material deposition, build platform calibration, and the control of environmental factors like temperature and humidity [170].
One of the primary concerns in ensuring compatibility is the integration of 3D printing equipment with robotic systems and CNC machines. Robotic arms, which are commonly used in automated manufacturing environments, often need to be reprogrammed or retrofitted to handle the specific movements and operations associated with 3D printing. For example, the precise control of extrusion rates, nozzle positioning, and the continuous monitoring of the build layer thickness require different programming and control systems than those used for traditional robotic tasks [171]. Additionally, when combining 3D printing with CNC or other subtractive systems, a seamless workflow must be established to allow for the transition between additive and subtractive steps. This can involve the development of sophisticated software platforms that enable the coordination of both additive and subtractive processes, ensuring that the parts produced meet quality standards while maintaining production efficiency [172]. The complexity of these integrations can be further exacerbated when different 3D printing technologies and materials are involved, requiring tailored solutions for each specific application.
Furthermore, achieving compatibility between 3D printing and traditional auto-mation systems also involves addressing the challenges associated with material han-dling and the synchronization of multi-stage production processes. In automated manufacturing environments, material handling is typically highly automated, with materials being fed into machines and conveyors without human intervention [173,174]. However, the variety of materials used in 3D printing, ranging from thermoplastics to metals and ceramics, often requires different handling procedures, including the need for specialized storage, preparation, and supply systems [175]. In addition, 3D printing may require different post-processing stages, such as curing or cooling, that traditional systems do not incorporate, which could disrupt the flow of the production line [176]. To ensure compatibility, these additional stages must be incorporated into the automated manufacturing process, which may require retrofitting existing systems or developing new automation protocols [177]. Therefore, achieving full compatibility between 3D printing and established automated systems requires not only advancements in hardware and material handling but also significant software development to enable smooth integration, coordination, and optimization of the overall production process.

4.4. Workforce and Skill Adaptation

A critical challenge in integrating 3D printing with automated manufacturing systems is the adaptation of the workforce, particularly in balancing human oversight with the increasing autonomy driven by artificial intelligence (AI) and machine learning (ML) [178]. As automation technologies advance, the role of human operators is evolving, with machines increasingly taking over tasks traditionally performed by humans. In the case of 3D printing, this shift is particularly pronounced as AI-driven systems gain the capability to autonomously optimize print parameters, detect defects, and adjust production workflows in real time [179]. However, this increased autonomy poses challenges in terms of ensuring effective human oversight, decision-making, and intervention when necessary. While automation promises to reduce the need for manual labor in some areas, it also requires workers to acquire new skills in areas such as programming, data analytics, and machine maintenance, in addition to understanding the complexities of the integrated 3D printing systems.
The integration of AI and machine learning into automated 3D printing workflows further complicates the relationship between human workers and machines [180]. AI-driven systems can continuously monitor production processes, learning from data to improve efficiency and predict potential issues, such as material shortages or machine malfunctions [181]. However, the growing reliance on AI introduces new risks related to system transparency and accountability. For example, if an AI system makes a decision that leads to a defect or malfunction, it may be difficult for human operators to understand why that decision was made or how to intervene effectively. Furthermore, the shift towards more autonomous manufacturing processes may reduce human involvement in critical decision-making, potentially leading to a loss of expertise and the development of overreliance on technology [182]. To mitigate these risks, it is essential to design systems that allow for effective collaboration between human workers and AI-driven systems. This collaboration should ensure that human expertise is still leveraged for high-level decision-making, while AI is used to handle repetitive, data-intensive tasks, thereby enhancing overall productivity and minimizing errors [183].
Moreover, as automation and AI-driven systems become more prevalent in 3D printing environments, there is a need to address the potential impact on the workforce in terms of job displacement and skill gaps [184]. While automation can lead to greater efficiency and cost savings, it may also result in a reduction in the number of manual labor positions, particularly for tasks that are repetitive or dangerous [185]. This shift could lead to concerns about job loss in certain sectors, especially in traditional manufacturing industries [186]. To address these concerns, it is crucial to invest in workforce development programs that equip workers with the necessary skills to operate and maintain advanced 3D printing systems [187]. This may involve offering training in areas such as robotics programming, AI and ML, data analysis, and additive manufacturing technologies. Additionally, organizations must foster a culture of continuous learning and upskilling to ensure that employees are able to adapt to rapidly changing technological landscapes [188]. Balancing the benefits of automation with the need for human involvement and skill development is essential for realizing the full potential of integrated 3D printing systems while ensuring that the workforce remains competitive and capable in an increasingly automated manufacturing environment [189]. Table 3 summarizes the key challenges faced in integrating 3D printing with automated manufacturing systems, along with their potential impacts and possible solutions to overcome these barriers.
Directly affecting the viability and scalability of combining 3D printing with automation, these four issues—material compatibility, process standardization, real-time monitoring, and integration with current production systems—Overcoming these challenges is absolutely necessary to reach the goal of the study, which is to assess how additive manufacturing could evolve from a prototyping tool to a completely integrated, automated production solution. If not taken into account, these challenges could compromise the advantages of automation in 3D printing by limiting production speed, uniformity, and quality. Therefore, understanding their implications enables a more realistic assessment of the technological, operational, and economic considerations necessary for successful integration.

5. Discussion: Synthesis of Opportunities and Challenges

At this level, exploring the future potential of automated 3D printing, this work focuses on the emerging trends and technological advancements that are poised to shape its evolution in the coming years. As 3D printing continues to integrate with automated manufacturing systems, several innovations—particularly in the areas of artificial intelligence (AI), machine learning (ML), and multi-material printing—are revolutionizing the capabilities of these systems. These technologies offer the potential to enhance operational efficiency, reduce production costs, and expand the functional range of 3D printed components. Additionally, the evolution of hybrid manufacturing systems, which combine both additive and subtractive processes, is positioning 3D printing as a central technology in advanced manufacturing ecosystems. Key trends, their implications for the future of manufacturing, and the role of regulatory frameworks and standardization in enabling the seamless integration of these technologies into industrial settings are examined. By analyzing these developments, the chapter highlights the significant impact these innovations are likely to have on the future of automated 3D printing and its adoption across various industries.

5.1. Emerging Trends: AI-Driven Self-Optimizing Printers, Multi-Material Printing and Hybrid Manufacturing

The future potential of automated 3D printing is heavily dependant on emerging technological trends, with artificial intelligence (AI) playing a pivotal role in advancing the capabilities of 3D printing systems. One of the most promising developments is the integration of AI-driven self-optimizing printers, which leverage machine learning algorithms to continuously monitor and adjust printing parameters in real-time [190]. This capability allows the system to make autonomous decisions based on live data from the printing process, such as changes in material flow, temperature fluctuations, and layer adhesion [191]. By adjusting these parameters dynamically, AI-driven systems can ensure that print quality is maintained throughout the production run, even in the face of variations in environmental conditions or material inconsistencies. Furthermore, AI can optimize the print path and layer deposition strategies to minimize waste, reduce print time, and improve the overall efficiency of the manufacturing process [192].
Machine learning, in particular, can be utilized to enhance the predictive capabilities of 3D printing systems, providing critical insights into potential failures before they occur [193]. Predictive maintenance is one area where AI has shown significant promise, as AI algorithms can analyze historical data from printers to predict when a component may fail or when a maintenance procedure is due [194]. This proactive approach to maintenance minimizes downtime, reduces the need for manual intervention, and ensures that the printing process remains uninterrupted [195]. In addition, AI can be employed to detect defects during the printing process by analyzing real-time sensor data, such as thermal readings, vibrations, or visual inspections through cameras. This defect detection capability allows for immediate corrective actions, ensuring that faulty prints are identified early and corrected without the need for post-production inspection, which can be costly and time-consuming [196].
Another important trend is the development of multi-material printing, which can further enhance the versatility and functionality of 3D-printed products. Multi-material printers can print objects with varying properties in different regions of the same part, allowing for the creation of complex geometries that would otherwise be difficult or impossible to achieve using a single material [197,198]. AI can play a crucial role in optimizing the distribution of materials within these multi-material prints, ensuring that each material is applied in the optimal location to achieve the desired mechanical, thermal, or electrical properties [199]. Moreover, hybrid manufacturing systems that combine additive and subtractive processes are becoming more common, with AI algorithms enabling the seamless transition between these processes [200]. These hybrid systems can leverage the strengths of both 3D printing and traditional machining methods, such as CNC milling or turning, to produce parts with superior surface finishes and precision, while maintaining the flexibility and complexity that 3D printing offers [201]. Thus, AI-driven advancements are not only improving the efficiency and performance of 3D printing systems but also expanding the possibilities for their applications across a wide range of industries.

5.2. The Role of Machine Learning in Predictive Maintenance and Defect Detection

The role of machine learning (ML) in automated 3D printing extends beyond simple process optimization; it is also pivotal in enhancing the predictability and reliability of the production process. ML algorithms can be integrated into 3D printing systems to analyze vast amounts of data generated during the printing process, enabling the detection of patterns and trends that may not be immediately obvious to human operators [202]. For instance, ML models can be trained to identify subtle changes in the print environment, such as variations in temperature, humidity, or material viscosity, and adjust the printer’s parameters in real-time to compensate for these changes [203]. This ability to continuously adapt ensures that the final printed object meets the desired specifications with minimal human intervention, increasing both the quality and consistency of the output. As the system collects more data, the algorithms improve over time, resulting in an increasingly autonomous process that requires less manual oversight [204].
Another significant advantage of ML in 3D printing is its application in predictive maintenance and defect detection [205]. By analyzing historical performance data from 3D printers, machine learning algorithms can predict potential issues before they occur, such as the wear and tear of critical components, or the likelihood of a failed print. For example, a printer may exhibit specific patterns of vibration or temperature fluctuations before a malfunction or print failure occurs [206]. With this predictive capability, ML algorithms can trigger maintenance alerts or adjustments to the printing process, allowing for timely interventions that prevent downtime or material waste. Additionally, ML can be employed to detect defects during the printing process by analyzing data from embedded sensors or real-time visual inspections [207]. By identifying deviations from the desired output early in the process, the system can either correct the issue autonomously or alert the operator for further action, reducing the need for post-production inspections or reprints.
Furthermore, machine learning enables the optimization of the entire 3D printing workflow, from material selection to print speed and layer resolution [208,209]. By an-alyzing the characteristics of different materials, ML models can predict the optimal printing conditions for a given material, enhancing the efficiency and quality of the print. For example, ML can help identify the most suitable combination of extrusion speed, nozzle temperature, and layer thickness for achieving the best mechanical properties for a specific application, such as increased tensile strength or flexibility [210]. Additionally, as 3D printing systems become more capable of handling multi-material prints, machine learning algorithms can assist in optimizing the distribution of materials within a part, ensuring that each material is used effectively to achieve the desired performance characteristics [211]. As the integration of ML progresses, it will improve the efficiency of 3D printing processes and enable new capabilities in the sector of additive manufacturing.

5.3. Standardization and Regulatory Considerations

As 3D printing continues to aid manufacturing and automated production systems, the need for standardization and regulatory frameworks becomes increasingly critical. The integration of 3D printing into industrial production lines, especially in sectors like aerospace, automotive, healthcare, and electronics, demands a robust set of standards to ensure consistency, safety, and interoperability. At present, there is a lack of universally adopted standards for many aspects of 3D printing, such as material specifications, part quality, and process parameters [212]. The absence of clear guidelines can lead to inconsistencies in the produced parts, affecting their reliability, safety, and overall performance. To address these challenges, regulatory bodies and standardization organizations are working to develop comprehensive frameworks that can guide the use of 3D printing in industrial applications [213]. These frameworks would cover critical areas, including material properties, print process standards, quality assurance protocols, and testing methods, enabling manufacturers to produce reliable and compliant products.
One of the primary concerns regarding standardization is the need to ensure compatibility across various 3D printing technologies and machines [214]. Different types of additive manufacturing processes, such as Fused Deposition Modeling (FDM), Stereolithography (SLA), and Selective Laser Sintering (SLS), each have their own distinct operational characteristics, and the materials used in these processes can vary significantly. To ensure that parts produced from different machines and technologies meet the same quality standards, there is a growing need for standardized material databases, process control methods, and testing protocols. Standardization can also foster greater collaboration across industries, as companies can rely on agreed-upon specifications and ensure that parts can be reproduced reliably at different manufacturing sites, regardless of the specific machine or technology used [215]. Furthermore, standardized certification programs would allow manufacturers to demonstrate the quality and safety of their 3D-printed parts, providing a higher level of assurance to both consumers and regulatory agencies [216,217].
In addition to material and process standardization, regulatory considerations must also address the broader implications of 3D printing in manufacturing, particularly with regard to intellectual property (IP) and environmental concerns [218]. The ease of replication enabled by 3D printing raises significant challenges for IP protection, as digital files can be easily shared and copied. This has prompted the need for more comprehensive laws and regulations that govern the ownership, sharing, and protection of digital designs [219]. Similarly, environmental regulations are becoming more pertinent as the widespread use of 3D printing has the potential to both reduce material waste and increase plastic waste, depending on the materials used and the recycling strategies employed [220]. Regulatory frameworks that encourage the use of sustainable materials and recycling processes will be essential in ensuring that the environmental impact of 3D printing remains manageable as the technology is adopted on a larger scale [221]. Thus, as 3D printing technology progresses, the development of standardized guidelines and regulatory frameworks will be crucial to ensure that it can be safely and effectively integrated into global manufacturing systems [222]. Table 4 synthesizes key trends and challenges facing the future of automated 3D printing, offering insights into how each development will shape the manufacturing landscape. It also highlights the regulatory and standardization efforts necessary to ensure safe, efficient, and sustainable implementation of these technologies.

6. Conclusions and Future Outlook

In summary, the integration of automated manufacturing systems and 3D printing represents an industrial structural shift. In this context, it is now possible to achieve greater levels of customization, efficiency, and sustainability and is accompanied by a set of opportunities and challenges destined to define the manufacturing of the future. Three-Dimensional printing technology will undoubtedly transform conventional manufacturing processes as it continues to evolve, thereby paving the ground for intelligent and adaptive methods of production.
The integration of 3D printing with automation will bring in smarter, more efficient, and more resilient manufacturing processes. Synergies like these overcome the current constraints to industrial processes by going beyond the limitations of problems like material waste, production rates, and scalability. Widespread deployment of the technologies, however, will pose serious challenges like maintaining product consistency, integrating innovative technologies with current processes, and transforming the work-force to match high-end automation.
The key novelty of this work lies in its integrative perspective, combining technical, organizational, and regulatory insights into a unified evaluation of additive manufacturing’s role within automated manufacturing ecosystems—combining technological analysis with broader systemic implications. This approach provides a comprehensive understanding of how additive manufacturing can be seamlessly integrated into existing manufacturing processes, while also addressing the regulatory and organizational challenges that come with technological advancements.
As these technologies mature, new opportunities will arise, making industries competitive, cheaper, and innovative. Successful integration of 3D printing into automated manufacturing processes has the potential to add value not only to the manufacturing capabilities but to product design, distribution, and product life cycle management as well. This synergy will prove to be of pivotal importance within industrial ecosystems of the future, contributing to a more efficient, sustainable, and resilient global manufacturing network.

Author Contributions

Conceptualization, A.K. and M.P.; methodology, M.P. and A.K.; validation, A.K. and C.D.; formal analysis, A.K. and M.P.; investigation, A.K. and C.D.; resources, A.K. and C.D.; writing—original draft preparation, A.K. and C.D.; writing—review and editing, A.K., C.D., M.P., E.P. and T.G.; visualization, A.K.; supervision, M.P., E.P. and T.G.; project administration, M.P. All authors have read and agreed to the published version of the manuscript.

Funding

This research received no external funding.

Data Availability Statement

No new data were created or analyzed in this study. Data sharing is not applicable to this article.

Conflicts of Interest

The authors declare no conflicts of interest.

Abbreviations

The following abbreviations are used in this manuscript:
AbbreviationFull Form
3DPThree-Dimensional Printing
AIArtificial Intelligence
CNCComputer Numerical Control
FDMFused Deposition Modeling
MLMachine Learning
SLAStereolithography
SLSSelective Laser Sintering
IPIntellectual Property
JITJust-In-Time
IoTInternet of Things
AI-DrivenArtificial Intelligence-Driven
ISOInternational Organization for Standardization
ASTMAmerican Society for Testing and Materials
ISO/IECInternational Organization for Standardization/International Electrotechnical Commission
AMAdditive Manufacturing
DMLSDirect Metal Laser Sintering
R&DResearch and Development

References

  1. Ashima, R.; Haleem, A.; Bahl, S.; Javaid, M.; Kumar Mahla, S.; Singh, S. Automation and Manufacturing of Smart Materials in Additive Manufacturing Technologies Using Internet of Things towards the Adoption of Industry 4.0. Mater. Today 2021, 45, 5081–5088. [Google Scholar] [CrossRef]
  2. Karumban, S.; Sanyal, S.; Laddunuri, M.M.; Dhanasingh Sivalinga, V.; Shanmugam, V.; Bose, V.; Mahesh, B.N.; Narasimhaiah, R.; Thangam, D.; Murugan, S.P. Industrial Automation and Its Impact on Manufacturing Industries. In Advances in Computational Intelligence and Robotics; IGI Global: Hershey, PA, USA, 2022; pp. 24–40. [Google Scholar]
  3. Lievano-Martínez, F.A.; Fernández-Ledesma, J.D.; Burgos, D.; Branch-Bedoya, J.W.; Jimenez-Builes, J.A. Intelligent Process Automation: An Application in Manufacturing Industry. Sustainability 2022, 14, 8804. [Google Scholar] [CrossRef]
  4. Dafflon, B.; Moalla, N.; Ouzrout, Y. The Challenges, Approaches, and Used Techniques of CPS for Manufacturing in Industry 4.0: A Literature Review. Int. J. Adv. Manuf. Technol. 2021, 113, 2395–2412. [Google Scholar] [CrossRef]
  5. Kantaros, A.; Ganetsos, T. Integration of Cyber-Physical Systems, Digital Twins and 3D Printing in Advanced Manufacturing: A Synergistic Approach. Am. J. Eng. Appl. Sci. 2024, 17, 1–22. [Google Scholar] [CrossRef]
  6. El-Haouzi, H.B.; Valette, E.; Krings, B.-J.; Moniz, A.B. Social Dimensions in CPS & IoT Based Automated Production Systems. Societies 2021, 11, 98. [Google Scholar] [CrossRef]
  7. Jamwal, A.; Agrawal, R.; Sharma, M.; Giallanza, A. Industry 4.0 Technologies for Manufacturing Sustainability: A Systematic Review and Future Research Directions. Appl. Sci. 2021, 11, 5725. [Google Scholar] [CrossRef]
  8. Fatima, Z.; Tanveer, M.H.; Waseemullah; Zardari, S.; Naz, L.F.; Khadim, H.; Ahmed, N.; Tahir, M. Production Plant and Warehouse Automation with IoT and Industry 5.0. Appl. Sci. 2022, 12, 2053. [Google Scholar] [CrossRef]
  9. Vieira, R.; Silva, D.; Ribeiro, E.; Perdigoto, L.; Coelho, P.J. Performance Evaluation of Computer Vision Algorithms in a Programmable Logic Controller: An Industrial Case Study. Sensors 2024, 24, 843. [Google Scholar] [CrossRef]
  10. Alexandropoulos, E.; Papoutsidakis, M.; Nikitakos, N. SCADA Backup System for the Control of Networked Valves in Modern Ships Facilities. Int. J. Comput. Appl. 2019, 178, 1–3. [Google Scholar] [CrossRef]
  11. Dzedzickis, A.; Subačiūtė-Žemaitienė, J.; Šutinys, E.; Samukaitė-Bubnienė, U.; Bučinskas, V. Advanced Applications of Industrial Robotics: New Trends and Possibilities. Appl. Sci. 2021, 12, 135. [Google Scholar] [CrossRef]
  12. Kubasakova, I.; Kubanova, J.; Benco, D.; Kadlecová, D. Implementation of Automated Guided Vehicles for the Automation of Selected Processes and Elimination of Collisions between Handling Equipment and Humans in the Warehouse. Sensors 2024, 24, 1029. [Google Scholar] [CrossRef] [PubMed]
  13. Pérez Estébanez, R. An Approach to Sustainable Enterprise Resource Planning System Implementation in Small- and Medium-Sized Enterprises. Adm. Sci. 2024, 14, 91. [Google Scholar] [CrossRef]
  14. Mastrantonas, A.; Kokkas, P.; Chatzopoulos, A.; Papoutsidakis, M.; Stergiou, C.; Vairis, A.; Kanetaki, Z. Identifying the Effects of Industry 4.0 in the Pharmaceutical Sector: Achieving the Sustainable Development Goals. Discov. Sustain. 2024, 5, 460. [Google Scholar] [CrossRef]
  15. Tsaramirsis, G.; Kantaros, A.; Al-Darraji, I.; Piromalis, D.; Apostolopoulos, C.; Pavlopoulou, A.; Alrammal, M.; Ismail, Z.; Buhari, S.M.; Stojmenovic, M.; et al. A Modern Approach towards an Industry 4.0 Model: From Driving Technologies to Management. J. Sens. 2022, 2022, 1–18. [Google Scholar] [CrossRef]
  16. Watch, F. Antifragile Manufacturing for People, Planet, and Profit with Passion. Available online: https://www.businessfinland.fi/4a5d8b/globalassets/julkaisut/industry-x-white-paper.pdf (accessed on 7 April 2025).
  17. Ahmad, I.; Rodriguez, F.; Kumar, T.; Suomalainen, J.; Jagatheesaperumal, S.K.; Walter, S.; Asghar, M.Z.; Li, G.; Papakonstantinou, N.; Ylianttila, M.; et al. Communications Security in Industry X: A Survey. IEEE Open J. Commun. Soc. 2024, 5, 982–1025. [Google Scholar] [CrossRef]
  18. Zikria, Y.B.; Ali, R.; Afzal, M.K.; Kim, S.W. Next-Generation Internet of Things (IoT): Opportunities, Challenges, and Solutions. Sensors 2021, 21, 1174. [Google Scholar] [CrossRef]
  19. Bourechak, A.; Zedadra, O.; Kouahla, M.N.; Guerrieri, A.; Seridi, H.; Fortino, G. At the Confluence of Artificial Intelligence and Edge Computing in IoT-Based Applications: A Review and New Perspectives. Sensors 2023, 23, 1639. [Google Scholar] [CrossRef]
  20. Xidias, E.; Zacharia, P. Balanced Task Allocation and Motion Planning of a Multi-Robot System under Fuzzy Time Windows. Eng. Comput. 2024, 41, 1301–1326. [Google Scholar] [CrossRef]
  21. Al-Sai, Z.A.; Husin, M.H.; Syed-Mohamad, S.M.; Abdin, R.M.S.; Damer, N.; Abualigah, L.; Gandomi, A.H. Explore Big Data Analytics Applications and Opportunities: A Review. Big Data Cogn. Comput. 2022, 6, 157. [Google Scholar] [CrossRef]
  22. Thayyib, P.V.; Mamilla, R.; Khan, M.; Fatima, H.; Asim, M.; Anwar, I.; Shamsudheen, M.K.; Khan, M.A. State-of-the-Art of Artificial Intelligence and Big Data Analytics Reviews in Five Different Domains: A Bibliometric Summary. Sustainability 2023, 15, 4026. [Google Scholar] [CrossRef]
  23. Kitsou, O.; Mavromoustakis, C.X.; Markakis, E.K.; Mastorakis, G.; Pallis, E.; Bourdena, A.; Kourgiantakis, M. Health Data Analytics: Frameworks, Tools, and Impact on the Administration Efficiency and Performance in Healthcare. In Signals and Communication Technology; Springer Nature: Cham, Switzerland, 2024; pp. 173–189. ISBN 9783031585265. [Google Scholar]
  24. Segovia, M.; Garcia-Alfaro, J. Design, Modeling and Implementation of Digital. Twins Sens. 2022, 22, 5396. [Google Scholar] [CrossRef] [PubMed]
  25. Piromalis, D.; Kantaros, A. Digital Twins in the Automotive Industry: The Road toward Physical-Digital Convergence. Appl. Syst. Innov. 2022, 5, 65. [Google Scholar] [CrossRef]
  26. Kantaros, A.; Piromalis, D. Setting up a Digital Twin Assisted Greenhouse Architecture. Am. J. Eng. Appl. Sci. 2022, 15, 230–238. [Google Scholar] [CrossRef]
  27. Kubiak, K.; Dec, G.; Stadnicka, D. Possible Applications of Edge Computing in the Manufacturing Industry-Systematic Literature Review. Sensors 2022, 22, 2445. [Google Scholar] [CrossRef]
  28. Abreha, H.G.; Hayajneh, M.; Serhani, M.A. Federated Learning in Edge Computing: A Systematic Survey. Sensors 2022, 22, 450. [Google Scholar] [CrossRef]
  29. Mijailović, Đ.; Đorđević, A.; Stefanovic, M.; Vidojević, D.; Gazizulina, A.; Projović, D. A Cloud-Based with Microcontroller Platforms System Designed to Educate Students within Digitalization and the Industry 4.0 Paradigm. Sustainability 2021, 13, 12396. [Google Scholar] [CrossRef]
  30. Babbar, H.; Rani, S.; Singh, A.; Abd-Elnaby, M.; Choi, B.J. Cloud Based Smart City Services for Industrial Internet of Things in Software-Defined Networking. Sustainability 2021, 13, 8910. [Google Scholar] [CrossRef]
  31. Kantaros, A.; Diegel, O.; Piromalis, D.; Tsaramirsis, G.; Khadidos, A.O.; Khadidos, A.O.; Khan, F.Q.; Jan, S. 3D Printing: Making an Innovative Technology Widely Accessible through Makerspaces and Outsourced Services. Mater. Today 2022, 49, 2712–2723. [Google Scholar] [CrossRef]
  32. Kantaros, A.; Zacharia, P.; Drosos, C.; Papoutsidakis, M.; Pallis, E.; Ganetsos, T. Smart Infrastructure and Additive Manufacturing: Synergies, Advantages, and Limitations. Appl. Sci. 2025, 15, 3719. [Google Scholar] [CrossRef]
  33. Arefin, A.M.E.; Khatri, N.R.; Kulkarni, N.; Egan, P.F. Polymer 3D Printing Review: Materials, Process, and Design Strategies for Medical Applications. Polymers 2021, 13, 1499. [Google Scholar] [CrossRef]
  34. Kantaros, A.; Petrescu, F.I.T.; Brachos, K.; Ganetsos, T.; Petrescu, N. Evaluating Benchtop Additive Manufacturing Processes Considering Latest Enhancements in Operational Factors. Processes 2024, 12, 2334. [Google Scholar] [CrossRef]
  35. Kantaros, A.; Soulis, E.; Ganetsos, T.; Petrescu, F.I.T. Applying a Combination of Cutting-Edge Industry 4.0 Processes towards Fabricating a Customized Component. Processes 2023, 11, 1385. [Google Scholar] [CrossRef]
  36. Kantaros, A.; Katsantoni, M.; Ganetsos, T.; Petrescu, N. The Evolution of Thermoplastic Raw Materials in High-Speed FFF/FDM 3D Printing Era: Challenges and Opportunities. Materials 2025, 18, 1220. [Google Scholar] [CrossRef] [PubMed]
  37. Pustišek, M.; Chen, M.; Kos, A.; Kos, A. Decentralized Machine Autonomy for Manufacturing Servitization. Sensors 2022, 22, 338. [Google Scholar] [CrossRef]
  38. Kantaros, A.; Petrescu, F.I.T.; Brachos, K.; Ganetsos, T.; Petrescu, N. Leveraging 3D Printing for Resilient Disaster Management in Smart Cities. Smart Cities 2024, 7, 3705–3726. [Google Scholar] [CrossRef]
  39. Nuñez Rodriguez, J.; Andrade Sosa, H.H.; Villarreal-Archila, S.M.; Ortiz, A. The Impact of Additive Manufacturing on Supply Chain Management from a System Dynamics Model—Scenario: Traditional, Centralized, and Distributed Supply Chain. Processes 2022, 10, 2489. [Google Scholar] [CrossRef]
  40. Assad, H.; Assad, A.; Kumar, A. Recent Developments in 3D Bio-Printing and Its Biomedical Applications. Pharmaceutics 2023, 15, 255. [Google Scholar] [CrossRef]
  41. Kantaros, A.; Petrescu, F.I.T.; Ganetsos, T. From Stents to Smart Implants Employing Biomimetic Materials: The Impact of 4D Printing on Modern Healthcare. Biomimetics 2025, 10, 125. [Google Scholar] [CrossRef]
  42. Kantaros, A.; Ganetsos, T. From Static to Dynamic: Smart Materials Pioneering Additive Manufacturing in Regenerative Medicine. Int. J. Mol. Sci. 2023, 24, 15748. [Google Scholar] [CrossRef]
  43. Kantaros, A. Bio-Inspired Materials: Exhibited Characteristics and Integration Degree in Bio-Printing Operations. Am. J. Eng. Appl. Sci. 2022, 15, 255–263. [Google Scholar] [CrossRef]
  44. Kantaros, A. 3D Printing in Regenerative Medicine: Technologies and Resources Utilized. Int. J. Mol. Sci. 2022, 23, 14621. [Google Scholar] [CrossRef] [PubMed]
  45. Žujović, M.; Obradović, R.; Rakonjac, I.; Milošević, J. 3D Printing Technologies in Architectural Design and Construction: A Systematic Literature Review. Buildings 2022, 12, 1319. [Google Scholar] [CrossRef]
  46. García-Alvarado, R.; Moroni-Orellana, G.; Banda-Pérez, P. Architectural Evaluation of 3D-Printed Buildings. Buildings 2021, 11, 254. [Google Scholar] [CrossRef]
  47. Živković, M.; Žujović, M.; Milošević, J. Architectural 3D-Printed Structures Created Using Artificial Intelligence: A Review of Techniques and Applications. Appl. Sci. 2023, 13, 10671. [Google Scholar] [CrossRef]
  48. Volpe, S.; Sangiorgio, V.; Petrella, A.; Coppola, A.; Notarnicola, M.; Fiorito, F. Building Envelope Prefabricated with 3D Printing Technology. Sustainability 2021, 13, 8923. [Google Scholar] [CrossRef]
  49. Romanczuk-Ruszuk, E.; Sztorch, B.; Pakuła, D.; Gabriel, E.; Nowak, K.; Przekop, R.E. 3D Printing Ceramics—Materials for Direct Extrusion Process. Ceramics 2023, 6, 364–385. [Google Scholar] [CrossRef]
  50. Kremzer, M.; Tomiczek, B.; Matula, G.; Gocki, M.; Krzemiński, Ł. Aluminium Matrix Composite Materials Reinforced by 3D-Printed Ceramic Preforms. Materials 2023, 16, 5473. [Google Scholar] [CrossRef]
  51. Mazeeva, A.; Masaylo, D.; Konov, G.; Popovich, A. Multi-Metal Additive Manufacturing by Extrusion-Based 3D Printing for Structural Applications: A Review. Metals 2024, 14, 1296. [Google Scholar] [CrossRef]
  52. Hartung, D.; Seidlitz, H.; Osiecki, T.; Sztorch, B.; Przekop, R.E.; Kazimierczuk, M. Flax Fiber Reinforced PET-G Composites with Improved Interfacial Adhesion. Polimery 2025, 70, 113–123. [Google Scholar] [CrossRef]
  53. Sztorch, B.; Romanczuk-Ruszuk, E.; Głowacka, J.; Kustosz, M.; Osiecki, T.; Jakubowska, P.; Seidlitz, H.; Przekop, R.E. Improving the Processing and Mechanical Properties of 3D Printable Biocomposite Based on Polylactide, Sediment Rock, and Natural Beeswax. Polym. Bull. 2024, 82, 2523–2553. [Google Scholar] [CrossRef]
  54. Konieczna, R.; Przekop, R.E.; Pakuła, D.; Głowacka, J.; Ziętkowska, K.; Kozera, R.; Sztorch, B. Functional Silsesquioxanes-Tailoring Hydrophobicity and Anti-Ice Properties of Polylactide in 3D Printing Applications. Materials 2024, 17, 4850. [Google Scholar] [CrossRef]
  55. Łapińska, A.; Grochowska, N.; Cieplak, K.; Płatek, P.; Wood, P.; Deuszkiewicz, P.; Dużyńska, A.; Sztorch, B.; Głowcka, J.; Przekop, R.; et al. Architecture Influence on Acoustic Performance, EMI Shielding, Electrical and Thermal, Properties of 3D Printed PLA/Graphite/Molybdenum Disulfide Composites. Mater. Des. 2024, 245, 113241. [Google Scholar] [CrossRef]
  56. Dabbagh, S.R.; Ozcan, O.; Tasoglu, S. Machine Learning-Enabled Optimization of Extrusion-Based 3D Printing. Methods 2022, 206, 27–40. [Google Scholar] [CrossRef] [PubMed]
  57. Ngoh, S. Case Study: An Industrial Automation Company Rethinks Fixturing with 3D Printing. Available online: https://www.xometry.com/resources/case-studies/case-study-industrial-automation-company-rethinks-fixturing-3d-printing/ (accessed on 11 April 2025).
  58. Kantaros, A. Intellectual Property Challenges in the Age of 3D Printing: Navigating the Digital Copycat Dilemma. Appl. Sci. 2024, 14, 11448. [Google Scholar] [CrossRef]
  59. Mehrpouya, M.; Dehghanghadikolaei, A.; Fotovvati, B.; Vosooghnia, A.; Emamian, S.S.; Gisario, A. The Potential of Additive Manufacturing in the Smart Factory Industrial 4.0: A Review. Appl. Sci. 2019, 9, 3865. [Google Scholar] [CrossRef]
  60. Chen, T.; Lin, Y.-C. Feasibility Evaluation and Optimization of a Smart Manufacturing System Based on 3D Printing: A Review: Smart Manufacturing System Based on 3d Printing. Int. J. Intell. Syst. 2017, 32, 394–413. [Google Scholar] [CrossRef]
  61. Soori, M.; Arezoo, B.; Dastres, R. Internet of Things for Smart Factories in Industry 4.0, a Review. Internet Things Cyber-Phys. Syst. 2023, 3, 192–204. [Google Scholar] [CrossRef]
  62. Jin, Y.; Gao, C. Hybrid Optimization of Green Supply Chain Network and Scheduling in Distributed 3D Printing Intelligent Factory. Sustainability 2023, 15, 5948. [Google Scholar] [CrossRef]
  63. De Antón, J.; Senovilla, J.; González, J.M.; Acebes, F. Production Planning in 3D Printing Factories. Int. J. Prod. Manag. Eng. 2020, 8, 75. [Google Scholar] [CrossRef]
  64. Meng, Y.; Yang, Y.; Chung, H.; Lee, P.-H.; Shao, C. Enhancing Sustainability and Energy Efficiency in Smart Factories: A Review. Sustainability 2018, 10, 4779. [Google Scholar] [CrossRef]
  65. Sajadieh, S.M.M.; Son, Y.H.; Noh, S.D. A Conceptual Definition and Future Directions of Urban Smart Factory for Sustainable Manufacturing. Sustainability 2022, 14, 1221. [Google Scholar] [CrossRef]
  66. Iftekar, S.F.; Aabid, A.; Amir, A.; Baig, M. Advancements and Limitations in 3D Printing Materials and Technologies: A Critical Review. Polymers 2023, 15, 2519. [Google Scholar] [CrossRef] [PubMed]
  67. Dahmani, A.; Benyoucef, L.; Mercantini, J.-M. Toward Sustainable Reconfigurable Manufacturing Systems (SRMS): Past, Present, and Future. Procedia Comput. Sci 2022, 200, 1605–1614. [Google Scholar] [CrossRef]
  68. Wang, R.; Tong, Y.; Zhuang, C. Lights-out Factories: Review and Prospect. Proc. Inst. Mech. Eng. Pt. B J. Eng. Manuf. 2024. [Google Scholar] [CrossRef]
  69. Nadimpalli, C.S.C.; Muttamsetty, L.S.; Pamu, R.N. Dark Factories and Lights-out Manufacturing: The Future of Production. In Advances in Finance, Accounting, and Economics; IGI Global: Hershey, PA, USA, 2025; pp. 233–266. ISBN 9798369370360. [Google Scholar]
  70. Jia, F.; Jebelli, A.; Ma, Y.; Ahmad, R. An Intelligent Manufacturing Approach Based on a Novel Deep Learning Method for Automatic Machine and Working Status Recognition. Appl. Sci. 2022, 12, 5697. [Google Scholar] [CrossRef]
  71. Popela, M.; Olivová, J.; Plíva, Z.; Petržílka, L.; Krchová, M.; Joska, Z.; Janů, P. A Novel Approach to the Production of Printed Patch Antennas. Appl. Sci. 2024, 14, 1556. [Google Scholar] [CrossRef]
  72. Zoubek, M.; Simon, M.; Poor, P. Overall Readiness of Logistics 4.0: A Comparative Study of Automotive, Manufacturing, and Electronics Industries in the West Bohemian Region (Czech Republic). Appl. Sci. 2022, 12, 7789. [Google Scholar] [CrossRef]
  73. Rahman, M.A.; Shakur, M.S.; Ahamed, M.S.; Hasan, S.; Rashid, A.A.; Islam, M.A.; Haque, M.S.S.; Ahmed, A. A Cloud-Based Cyber-Physical System with Industry 4.0: Remote and Digitized Additive Manufacturing. Automation 2022, 3, 400–425. [Google Scholar] [CrossRef]
  74. Ullrich, M.; Thalappully, R.; Heieck, F.; Lüdemann-Ravit, B. Virtual Commissioning of Linked Cells Using Digital Models in an Industrial Metaverse. Automation 2024, 5, 1–12. [Google Scholar] [CrossRef]
  75. Christ, L.; Milloch, E.; Boshoff, M.; Hypki, A.; Kuhlenkötter, B. Implementation of Digital Twin and Real Production System to Address Actual and Future Challenges in Assembly Technology. Automation 2023, 4, 345–358. [Google Scholar] [CrossRef]
  76. Zani, C.M.; Rocha, C.G. da Product and Process Complexity in Construction: An Exploratory Study Using Bill-of-Materials (Bom). In Proceedings of the Annual Conference of the International Group for Lean Construction, Lisbon, Portugal, 3–7 July 2023; pp. 711–722. [Google Scholar]
  77. Sánchez Ros, E. A Cost Comparison of Outsourcing Amb Insourcing in 3D Printer Manufacturing. Bachelor’s Thesis, Universitat Politècnica de Catalunya, Barcelona, Spain, 2024. [Google Scholar]
  78. Al Rashid, A.; Koç, M. Additive Manufacturing for Sustainability and Circular Economy: Needs, Challenges, and Opportunities for 3D Printing of Recycled Polymeric Waste. Materials Today Sustainability 2023, 24, 100529. [Google Scholar] [CrossRef]
  79. Samad, A. International Journal of Multidisciplinary Sciences and Arts. Inf. Technol. Sci. 2024, 4, 2. [Google Scholar]
  80. Zgodavová, K.; Lengyelová, K.; Bober, P.; Eguren, J.A.; Moreno, A. 3D Printing Optimization for Environmental Sustainability: Experimenting with Materials of Protective Face Shield Frames. Materials 2021, 14, 6595. [Google Scholar] [CrossRef]
  81. Tabassum, T.; Ahmad Mir, A. A Review of 3d Printing Technology-the Future of Sustainable Construction. Mater. Today 2023, 93, 408–414. [Google Scholar] [CrossRef]
  82. Prashar, G.; Vasudev, H.; Bhuddhi, D. Additive Manufacturing: Expanding 3D Printing Horizon in Industry 4.0. Int. J. Interact. Des. Manuf. 2023, 17, 2221–2235. [Google Scholar] [CrossRef]
  83. Elbadawi, M.; Li, H.; Sun, S.; Alkahtani, M.E.; Basit, A.W.; Gaisford, S. Artificial Intelligence Generates Novel 3D Printing Formulations. Appl. Mater. Today 2024, 36, 102061. [Google Scholar] [CrossRef]
  84. Yang, C.-J. Accelerated Quality Improvement of 3D Printed Objects Based on a Case-Based Reasoning System. Int. J. Adv. Manuf. Technol. 2022, 119, 4599–4612. [Google Scholar] [CrossRef]
  85. Kantaros, A.; Ganetsos, T.; Tseles, D. 3D Printing and 3D Scanning: Applications in the Cultural Heritage Field. In Proceedings of the International Scientific Conference Modern Research Methods of Bio-Nano-Agents, Batumi, Georgia, 24–26 November 2021. [Google Scholar] [CrossRef]
  86. Lengyel, F. Generative AI in the Printing Industry: Revolutionizing Workflow, Design, and Efficiency. Preprint 2024. [Google Scholar]
  87. Nguyen, H.; Adrian, N.; Yan, J.L.X.; Salfity, J.M.; Allen, W.; Pham, Q.-C. Development of a Robotic System for Automated Decaking of 3D-Printed Parts. In Proceedings of the 2020 IEEE International Conference on Robotics and Automation (ICRA), Paris, France, 1 January 2020. [Google Scholar]
  88. Bouchard, S.; Gamache, S.; Abdulnour, G. Operationalizing Mass Customization in Manufacturing SMEs—A Systematic Literature Review. Sustainability 2023, 15, 3028. [Google Scholar] [CrossRef]
  89. Pech, M.; Vrchota, J. The Product Customization Process in Relation to Industry 4.0 and Digitalization. Processes 2022, 10, 539. [Google Scholar] [CrossRef]
  90. Martínez-Olvera, C. Towards the Development of a Digital Twin for a Sustainable Mass Customization 4.0 Environment: A Literature Review of Relevant Concepts. Automation 2022, 3, 197–222. [Google Scholar] [CrossRef]
  91. Qin, Z.; Lu, Y. Self-Organizing Manufacturing Network: A Paradigm towards Smart Manufacturing in Mass Personalization. J. Manuf. Syst. 2021, 60, 35–47. [Google Scholar] [CrossRef]
  92. Bortolini, M.; Faccio, M.; Galizia, F.G.; Gamberi, M.; Pilati, F. Adaptive Automation Assembly Systems in the Industry 4.0 Era: A Reference Framework and Full–Scale Prototype. Appl. Sci. 2021, 11, 1256. [Google Scholar] [CrossRef]
  93. Eid Mohamed, B.; Carbone, C. Mass Customization of Housing: A Framework for Harmonizing Individual Needs with Factory Produced Housing. Buildings 2022, 12, 955. [Google Scholar] [CrossRef]
  94. Carqueijó, S.; Ramos, D.; Gonçalves, J.; Carvalho, S.; Murmura, F.; Bravi, L.; Doiro, M.; Santos, G.; Zgodavová, K. The Importance of Fab Labs in the Development of New Products toward Mass Customization. Sustainability 2022, 14, 8671. [Google Scholar] [CrossRef]
  95. Guo, S.; Choi, T.-M.; Chung, S.-H. Self-Design Fun: Should 3D Printing Be Employed in Mass Customization Operations? Eur. J. Oper. Res. 2022, 299, 883–897. [Google Scholar] [CrossRef]
  96. Jin, Y.; Campbell, R.; Tang, J.; Ji, H.; Song, D.; Liu, X. Designing and Simulating a “Mass Selective Customization-Centralized Manufacturing” Business Model for Clothing Enterprises Using 3D Printing. Rapid Prototyp. J. 2021, 27, 1664–1680. [Google Scholar] [CrossRef]
  97. Dong, L.; Shi, D.; Zhang, F. 3D Printing and Product Assortment Strategy. Manag. Sci. 2022, 68, 5724–5744. [Google Scholar] [CrossRef]
  98. Habib, T.; Omair, M.; Habib, M.S.; Zahir, M.Z.; Khattak, S.B.; Yook, S.-J.; Aamir, M.; Akhtar, R. Modular Product Architecture for Sustainable Flexible Manufacturing in Industry 4.0: The Case of 3D Printer and Electric Toothbrush. Sustainability 2023, 15, 910. [Google Scholar] [CrossRef]
  99. Cui, T.Z.; Raji, R.K.; Han, J.L.; Chen, Y. Application of 3D Printing Technology in Footwear Design and Manufacture–A Review of Developing Trends. Text. Leather Rev. 2024, 7, 1304–1321. [Google Scholar] [CrossRef]
  100. Zavodna, L.; Trejtnarová, L. Additive Manufacturing in the Footwear Industry. Available online: https://www.researchgate.net/publication/370952638_ADDITIVE_MANUFACTURING_IN_THE_FOOTWEAR_INDUSTRY (accessed on 11 April 2025).
  101. Kantaros, A.; Ganetsos, T.; Petrescu, F.I.T.; Alysandratou, E. Bioprinting and Intellectual Property: Challenges, Opportunities, and the Road Ahead. Bioengineering 2025, 12, 76. [Google Scholar] [CrossRef]
  102. Kantaros, A.; Petrescu, F.; Abdoli, H.; Diegel, O.; Chan, S.; Iliescu, M.; Ganetsos, T.; Munteanu, I.; Ungureanu, L. Additive Manufacturing for Surgical Planning and Education: A Review. Appl. Sci. 2024, 14, 2550. [Google Scholar] [CrossRef]
  103. Pérez-Davila, S.; González-Rodríguez, L.; Lama, R.; López-Álvarez, M.; Oliveira, A.L.; Serra, J.; Novoa, B.; Figueras, A.; González, P. 3D-Printed PLA Medical Devices: Physicochemical Changes and Biological Response after Sterilisation Treatments. Polymers 2022, 14, 4117. [Google Scholar] [CrossRef]
  104. M’Bengue, M.-S.; Mesnard, T.; Chai, F.; Maton, M.; Gaucher, V.; Tabary, N.; García-Fernandez, M.-J.; Sobocinski, J.; Martel, B.; Blanchemain, N. Evaluation of a Medical Grade Thermoplastic Polyurethane for the Manufacture of an Implantable Medical Device: The Impact of FDM 3D-Printing and Gamma Sterilization. Pharmaceutics 2023, 15, 456. [Google Scholar] [CrossRef]
  105. Jayawardane, H.; Davies, I.J.; Gamage, J.R.; John, M.; Biswas, W.K. Investigating the ‘Techno-Eco-Efficiency’ Performance of Pump Impellers: Metal 3D Printing vs. CNC Machining. Int. J. Adv. Manuf. Technol. 2022, 121, 6811–6836. [Google Scholar] [CrossRef]
  106. Alves, A.S.F.; Kokare, S.; Oliveira, J.P.; Godina, R. Environmental Comparison of Wire and Arc Additive Manufacturing and CNC Milling on Steel Produced Parts. Procedia Comput. Sci. 2025, 253, 3025–3036. [Google Scholar] [CrossRef]
  107. Brion, D.A.J.; Pattinson, S.W. Quantitative and Real-time Control of 3D Printing Material Flow through Deep Learning. Adv. Intell. Syst. 2022, 4, 2200153. [Google Scholar] [CrossRef]
  108. Xie, J.; Saluja, A.; Rahimizadeh, A.; Fayazbakhsh, K. Development of Automated Feature Extraction and Convolutional Neural Network Optimization for Real-Time Warping Monitoring in 3D Printing. Int. J. Comput. Integr. Manuf. 2022, 35, 813–830. [Google Scholar] [CrossRef]
  109. Mantalas, E.-M.; Sagias, V.D.; Zacharia, P.; Stergiou, C.I. Neuro-Fuzzy Model Evaluation for Enhanced Prediction of Mechanical Properties in AM Specimens. Appl. Sci. 2024, 15, 7. [Google Scholar] [CrossRef]
  110. Sagias, V.D.; Zacharia, P.; Tempeloudis, A.; Stergiou, C. Adaptive Neuro-Fuzzy Inference System-Based Predictive Modeling of Mechanical Properties in Additive Manufacturing. Machines 2024, 12, 523. [Google Scholar] [CrossRef]
  111. Siddiqui, M.M.U.Z.; Tabassum, A. Condition-Based Monitoring Techniques and Algorithms in 3d Printing and Additive Manufacturing: A State-of-the-Art Review. Prog. Addit. Manuf. 2024. [Google Scholar] [CrossRef]
  112. Jandyal, A.; Chaturvedi, I.; Wazir, I.; Raina, A.; Ul Haq, M.I. 3D Printing–A Review of Processes, Materials and Applications in Industry 4.0. Sustain. Oper. Comput. 2022, 3, 33–42. [Google Scholar] [CrossRef]
  113. Samal, S.K.; Vishwanatha, H.M.; Saxena, K.K.; Behera, A.; Nguyen, T.A.; Behera, A.; Prakash, C.; Dixit, S.; Mohammed, K.A. 3D-Printed Satellite Brackets: Materials, Manufacturing and Applications. Crystals 2022, 12, 1148. [Google Scholar] [CrossRef]
  114. Hedayati, R.; Stulova, V. 3D Printing for Space Habitats: Requirements, Challenges, and Recent Advances. Aerospace 2023, 10, 653. [Google Scholar] [CrossRef]
  115. Kantaros, A.; Ganetsos, T.; Piromalis, D. 4D Printing: Technology Overview and Smart Materials Utilized. J. Mechatron. Robot. 2023, 7, 1–14. [Google Scholar] [CrossRef]
  116. Kantaros, A.; Piromalis, D. Fabricating Lattice Structures via 3D Printing: The Case of Porous Bio-Engineered Scaffolds. Appl. Mech. 2021, 2, 289–302. [Google Scholar] [CrossRef]
  117. Serrano, D.R.; Kara, A.; Yuste, I.; Luciano, F.C.; Ongoren, B.; Anaya, B.J.; Molina, G.; Diez, L.; Ramirez, B.I.; Ramirez, I.O.; et al. 3D Printing Technologies in Personalized Medicine, Nanomedicines, and Biopharmaceuticals. Pharmaceutics 2023, 15, 313. [Google Scholar] [CrossRef]
  118. Zakaria, S.; Mativenga, P. A Scientific Base for Optimising Energy Consumption and Performance in 3D Printing. J. Clean. Prod. 2024, 482, 144227. [Google Scholar] [CrossRef]
  119. Mohamed, R.A.; Mohamed, A.F.A. Exploring the Environmental Benefits of 3D Printing Technology in Concrete Construction; a Review. Prog. Addit. Manuf. 2025, 10, 279–289. [Google Scholar] [CrossRef]
  120. Ulkir, O. Energy-Consumption-Based Life Cycle Assessment of Additive-Manufactured Product with Different Types of Materials. Polymers 2023, 15, 1466. [Google Scholar] [CrossRef]
  121. Lara, A.C.; Menegon, E.M.P.; Sehnem, S.; Kuzma, E. Relationship between Just in Time, Lean Manufacturing, and Performance Practices: A Meta-Analysis. Gest. Prod. 2022, 29, e9021. [Google Scholar] [CrossRef]
  122. Görmen, M. Statistical Process Control (SPC) under the Quality Approach of Just in Time (JIT) Manufacturing Philosophie and an Application. J. Bus. Res.-Turk. 2022, 14, 646–670. [Google Scholar] [CrossRef]
  123. Singhal, V.; Maiyar, L.M.; Roy, I. Environmental Sustainability Consideration with Just-in-Time Practices in Industry 4.0 Era—A State of the Art. Oper. Manag. Res. 2024. [Google Scholar] [CrossRef]
  124. Pillai, A.S.; Thonakkot, L.S. Just in Time (Jit): A Literature Review. NIJASET 2023, 2, 6–14. [Google Scholar]
  125. García-Cutrín, J.; Rodríguez-García, C. Enhancing Corporate Sustainability through Just-in-Time (JIT) Practices: A Meta-Analytic Examination of Financial Performance Outcomes. Sustainability 2024, 16, 4025. [Google Scholar] [CrossRef]
  126. Chen, L.; Cui, Y.; Lee, H.L. Retailing with 3D Printing. Prod. Oper. Manag. 2021, 30, 1986–2007. [Google Scholar] [CrossRef]
  127. Westerweel, B.; Basten, R.; den Boer, J.; van Houtum, G.-J. Printing Spare Parts at Remote Locations: Fulfilling the Promise of Additive Manufacturing. Prod. Oper. Manag. 2021, 30, 1615–1632. [Google Scholar] [CrossRef]
  128. Katsaliaki, K.; Galetsi, P.; Kumar, S. Supply Chain Disruptions and Resilience: A Major Review and Future Research Agenda. Ann. Oper. Res. 2022, 319, 965–1002. [Google Scholar] [CrossRef]
  129. Serohi, A. Impact of 3-D Printing Technology in Manufacturing Supply Lines to Improve Resilience during Black Swan Events. Int.J Sup. Chain. Mgt. 2021, 10, 3, 8–103. [Google Scholar] [CrossRef]
  130. Ali, A.A.A.; Fayad, A.A.S.; Alomair, A.; Al Naim, A.S. The Role of Digital Supply Chain on Inventory Management Effectiveness within Engineering Companies in Jordan. Sustainability 2024, 16, 8031. [Google Scholar] [CrossRef]
  131. Montes, J.O.; Olleros, F.X. Local On-Demand Fabrication: Microfactories and Online Manufacturing Platforms. J. Manuf. Technol. Manag. 2020, 32, 20–41. [Google Scholar] [CrossRef]
  132. Capellades, G.; Neurohr, C.; Briggs, N.; Rapp, K.; Hammersmith, G.; Brancazio, D.; Derksen, B.; Myerson, A.S. On-Demand Continuous Manufacturing of Ciprofloxacin in Portable Plug-and-Play Factories: Implementation and in Situ Control of Downstream Production. Org. Process Res. Dev. 2021, 25, 1534–1546. [Google Scholar] [CrossRef]
  133. Pennekamp, J.; Matzutt, R.; Kanhere, S.S.; Hiller, J.; Wehrle, K. The Road to Accountable and Dependable Manufacturing. Automation 2021, 2, 202–219. [Google Scholar] [CrossRef]
  134. McDougall, N.; Wagner, B.; MacBryde, J. Leveraging Competitiveness from Sustainable Operations: Frameworks to Understand the Dynamic Capabilities Needed to Realise NRBV Supply Chain Strategies. Supply Chain. Manag. Int. J. 2022, 27, 12–29. [Google Scholar] [CrossRef]
  135. Ventura, J.A.; Golany, B.; Mendoza, A.; Li, C. A Multi-Product Dynamic Supply Chain Inventory Model with Supplier Selection, Joint Replenishment, and Transportation Cost. Ann. Oper. Res. 2022, 316, 729–762. [Google Scholar] [CrossRef]
  136. Moosavi, J.; Fathollahi-Fard, A.M.; Dulebenets, M.A. Supply Chain Disruption during the COVID-19 Pandemic: Recognizing Potential Disruption Management Strategies. Int. J. Disaster Risk Reduct. 2022, 75, 102983. [Google Scholar] [CrossRef]
  137. Sudan, T.; Taggar, R.; Jena, P.K.; Sharma, D. Supply Chain Disruption Mitigation Strategies to Advance Future Research Agenda: A Systematic Literature Review. J. Clean. Prod. 2023, 425, 138643. [Google Scholar] [CrossRef]
  138. Katsigiannis, M.; Evans, M.; Osho, J.; Pantelidakis, M.; Bitencourt, J.; Mykoniatis, K. Empowering Decentralized Production: A Distributed Manufacturing System for Additive Manufacturing Processes. Manuf. Lett. 2024, 41, 1507–1514. [Google Scholar] [CrossRef]
  139. Poudel, L.; Elagandula, S.; Zhou, W.; Sha, Z. Decentralized and Centralized Planning for Multi-Robot Additive Manufacturing. J. Mech. Des. 2023, 145, 10. [Google Scholar] [CrossRef]
  140. Makanda, I.L.D.; Yang, M.; Shi, H.; Guo, W.; Jiang, P. A Multi-Part Production Planning System for a Distributed Network of 3D Printers under the Context of Social Manufacturing. Machines 2022, 10, 605. [Google Scholar] [CrossRef]
  141. Chadha, U.; Abrol, A.; Vora, N.P.; Tiwari, A.; Shanker, S.K.; Selvaraj, S.K. Performance Evaluation of 3D Printing Technologies: A Review, Recent Advances, Current Challenges, and Future Directions. Prog. Addit. Manuf. 2022, 7, 853–886. [Google Scholar] [CrossRef]
  142. Malik, A.; Ul Haq, M.I.; Raina, A.; Gupta, K. 3D Printing towards Implementing Industry 4.0: Sustainability Aspects, Barriers and Challenges. Ind. Rob. 2022, 49, 491–511. [Google Scholar] [CrossRef]
  143. Bănică, C.-F.; Sover, A.; Anghel, D.-C. Printing the Future Layer by Layer: A Comprehensive Exploration of Additive Manufacturing in the Era of Industry 4.0. Appl. Sci. 2024, 14, 9919. [Google Scholar] [CrossRef]
  144. Kannaki, S.; Sooraj, S.; Vijeth, R.; Selvalakshmi, S.U.; Sharmietha, S.P.; Sruthi, S. Fabrication of Multi-Purpose 3D Printer (3D Printer, CNC & Laser Engraving). In Proceedings of the AIP Conference Proceedings, Melville, NY, USA, 5 February 2025; Volume 3262, p. 030013. [Google Scholar]
  145. Xu, Z.; Song, T.; Guo, S.; Peng, J.; Zeng, L.; Zhu, M. Robotics Technologies Aided for 3D Printing in Construction: A Review. Int. J. Adv. Manuf. Technol. 2022, 118, 3559–3574. [Google Scholar] [CrossRef]
  146. Lishchenko, N.; Piteľ, J.; Larshin, V. Online Monitoring of Surface Quality for Diagnostic Features in 3D Printing. Machines 2022, 10, 541. [Google Scholar] [CrossRef]
  147. Portoacă, A.I.; Ripeanu, R.G.; Diniță, A.; Tănase, M. Optimization of 3D Printing Parameters for Enhanced Surface Quality and Wear Resistance. Polymers 2023, 15, 3410. [Google Scholar] [CrossRef]
  148. Kantaros, A.; Karalekas, D. In-Situ Monitoring of Strain Build up and Temperature in a 3D Polymer Printing Process. In Proceedings of the 16th International Conference on Experimental Mechanics (ICEM16), Cambridge, UK, 7–11 July 2022. [Google Scholar]
  149. Kantaros, A.; Bimis, A.; Karalekas, D. In Situ Characterization of Residual Strains in Layered Manufacturing. In Proceedings of the 5th International Conference on Materials Integrated Non Destructive Testing (IC-MINDT-2013), Athens, Greece, 20–22 May 2025. [Google Scholar]
  150. Phillips, C.; Kortschot, M.; Azhari, F. Towards Standardizing the Preparation of Test Specimens Made with Material Extrusion: Review of Current Techniques for Tensile Testing. Addit. Manuf. 2022, 58, 103050. [Google Scholar] [CrossRef]
  151. Alexander, A.E.; Wake, N.; Chepelev, L.; Brantner, P.; Ryan, J.; Wang, K.C. A Guideline for 3D Printing Terminology in Biomedical Research Utilizing ISO/ASTM Standards. 3D Print. Med. 2021, 7, 8. [Google Scholar] [CrossRef]
  152. Głowacki, M.; Mazurkiewicz, A.; Słomion, M.; Skórczewska, K. Resistance of 3D-Printed Components, Test Specimens and Products to Work under Environmental Conditions-Review. Materials 2022, 15, 6162. [Google Scholar] [CrossRef]
  153. Rojek, I.; Mikołajewski, D.; Macko, M.; Szczepański, Z.; Dostatni, E. Optimization of Extrusion-Based 3D Printing Process Using Neural Networks for Sustainable Development. Materials 2021, 14, 2737. [Google Scholar] [CrossRef]
  154. Ferretti, P.; Leon-Cardenas, C.; Santi, G.M.; Sali, M.; Ciotti, E.; Frizziero, L.; Donnici, G.; Liverani, A. Relationship between FDM 3D Printing Parameters Study: Parameter Optimization for Lower Defects. Polymers 2021, 13, 2190. [Google Scholar] [CrossRef]
  155. Rojek, I.; Mikołajewski, D.; Kotlarz, P.; Tyburek, K.; Kopowski, J.; Dostatni, E. Traditional Artificial Neural Networks versus Deep Learning in Optimization of Material Aspects of 3D Printing. Materials 2021, 14, 7625. [Google Scholar] [CrossRef]
  156. Jackson, B.; Fouladi, K.; Eslami, B. Multi-Parameter Optimization of 3D Printing Condition for Enhanced Quality and Strength. Polymers 2022, 14, 1586. [Google Scholar] [CrossRef]
  157. Yang, C.-J.; Wu, S.-S. Sustainable Manufacturing Decisions through the Optimization of Printing Parameters in 3D Printing. Appl. Sci. 2022, 12, 10060. [Google Scholar] [CrossRef]
  158. Antreas, K.; Piromalis, D. Employing a Low-Cost Desktop 3D Printer: Challenges, and How to Overcome Them by Tuning Key Process Parameters. Int. J. Mech. Appl. 2021, 10, 11–19. [Google Scholar] [CrossRef]
  159. Kim, M.; Yoo, G.; Kim, B.; Song, Y.; Lee, B.J. Scalability Enhancement in Projection-Based 3D Printing through Optical Expansion. Addit. Manuf. 2024, 95, 104511. [Google Scholar] [CrossRef]
  160. Aizawa, T.; Yoshino, T.; Suzuki, Y.; Inohara, T. Micro-/Nano-Texturing onto Plasma-Nitrided Tool Surface by Laser Printing for CNC Imprinting and Piercing. Micromachines 2022, 13, 265. [Google Scholar] [CrossRef]
  161. Herpel, C.; Tasaka, A.; Higuchi, S.; Finke, D.; Kühle, R.; Odaka, K.; Rues, S.; Lux, C.J.; Yamashita, S.; Rammelsberg, P.; et al. Accuracy of 3D Printing Compared with Milling—A Multi-Center Analysis of Try-in Dentures. J. Dent. 2021, 110, 103681. [Google Scholar] [CrossRef]
  162. Popescu, D.; Gheorghe Amza, C.; Marinescu, R.; Cristiana Iacob, M.; Luminiţa Căruţaşu, N. Investigations on Factors Affecting 3D-Printed Holes Dimensional Accuracy and Repeatability. Appl. Sci. 2022, 13, 41. [Google Scholar] [CrossRef]
  163. Kantaros, A.; Karalekas, D. FBG Based in Situ Characterization of Residual Strains in FDM Process. In Residual Stress, Thermomechanics & Infrared Imaging, Hybrid Techniques and Inverse Problems; Springer International Publishing: Cham, Switzerland, 2014; Volume 8, pp. 333–337. ISBN 9783319008752. [Google Scholar]
  164. Lorkowski, L.; Wybrzak, K.; Brancewicz-Steinmetz, E.; Świniarski, J.; Sawicki, J. Influence of Print Speed on the Mechanical Performance of 3D-Printed Bio-Polymer Polylactic Acid. Materials 2025, 18, 1765. [Google Scholar] [CrossRef]
  165. Kantaros, A.; Ganetsos, T.; Petrescu, F.; Ungureanu, L.; Munteanu, I. Post-Production Finishing Processes Utilized in 3D Printing Technologies. Processes 2024, 12, 595. [Google Scholar] [CrossRef]
  166. Amirpour, M.; Cracknell, D.; Amirian, A.; Alipour, A.N. Hybrid 3D Printing of Fluid-Filled Lattices for Biomedical Applications: A Review. Int. J. Adv. Manuf. Technol. 2025, 136, 4083–4105. [Google Scholar] [CrossRef]
  167. Dai, Y.; Lu, Y. 3D Printing Driven Business Model Innovation and Supply Chain Operations: A Perspective of Strategic Alignment. J. Manuf. Technol. Manag. 2025, 36, 820–839. [Google Scholar] [CrossRef]
  168. Miri, Z.S.; Baaj, H.; Polak, M.A. 3D-Printed Concrete Bridges: Material, Design, Construction, and Reinforcement. Appl. Sci. 2025, 15, 3054. [Google Scholar] [CrossRef]
  169. Zuo, Z.; Zhang, Y.; Li, J.; Huang, Y.; Zhang, L.; Wang, X.; Tao, Y.; De Corte, W. Systematic Workflow for Digital Design and On-Site 3D Printing of Large Concrete Structures: A Case Study of a Full-Size Two-Story Building. J. Build. Eng. 2025, 104, 112370. [Google Scholar] [CrossRef]
  170. Saif, H.M.; Crespo, J.G.; Pawlowski, S. Can 3D-Printed Flow Electrode Gaskets Replace CNC-Milled Graphite Current Collectors in Flow Capacitive Deionization? Desalination 2025, 597, 118362. [Google Scholar] [CrossRef]
  171. Alghamdi, A. Enhancing 3D Printing Workflows through Multi-Objective Optimization and Reinforcement Learning Techniques. Eng. Technol. Appl. Sci. Res. 2025, 15, 21300–21305. [Google Scholar] [CrossRef]
  172. İnal, C.B.; Ayten, U.B.C.; Nemli, S.K. Replacement Implant-Retained Ear Prosthesis Using a Semidigital Workflow: A Case Report. Int. J. Prosthodont. 2025, 25, 268–270. [Google Scholar] [CrossRef]
  173. Jiménez-Sarda, J.; Silva, D.F.; Smith, A.E. Drone-enabled Material Handling in Smart Manufacturing. Int. Trans. Oper. Res. 2025. [Google Scholar] [CrossRef]
  174. Naranbat, D.; Phelps, B.; Murphy, J.; Tripathi, A. How to Convert a 3D Printer to a Personal Automated Liquid Handler for Life Science Workflows. SLAS Technol. 2025, 30, 100239. [Google Scholar] [CrossRef]
  175. Kantaros, A.; Soulis, E.; Petrescu, F.I.T.; Ganetsos, T. Advanced Composite Materials Utilized in FDM/FFF 3D Printing Manufacturing Processes: The Case of Filled Filaments. Materials 2023, 16, 6210. [Google Scholar] [CrossRef]
  176. Kumar, A.; Kumar, N.; Puttapati, S.K. Advancing Optical Transparency in 3D-printed PLA Parts Using Chemical Post-processing. Polym. Eng. Sci. 2025, 65, 299–314. [Google Scholar] [CrossRef]
  177. Regassa Hunde, B.; Debebe Woldeyohannes, A. Future Prospects of Computer-Aided Design (CAD)–A Review from the Perspective of Artificial Intelligence (AI), Extended Reality, and 3D Printing. Results Eng. 2022, 14, 100478. [Google Scholar] [CrossRef]
  178. Talaat, F.M.; Hassan, E. Artificial Intelligence in 3D Printing. In Enabling Machine Learning Applications in Data Science; Springer: Singapore, 2021; pp. 77–88. ISBN 9789813361287. [Google Scholar]
  179. Soori, M.; Jough, F.K.G.; Dastres, R.; Arezoo, B. Additive Manufacturing Modification by Artificial Intelligence, Machine Learning, and Deep Learning: A Review. Addit. Manuf. Front. 2025, 4, 200198. [Google Scholar] [CrossRef]
  180. Chi, X.; Xue, J.; Jia, L.; Yao, J.; Miao, H.; Wu, L.; Liu, T.; Tian, X.; Li, D. Machine Learning-Based Online Monitoring and Closed-Loop Controlling for 3D Printing of Continuous Fiber-Reinforced Composites. Addit. Manuf. Front. 2025, 4, 200196. [Google Scholar] [CrossRef]
  181. Belmouadden, M.; Dadouchi, C.; Pellerin, R. Artificial Intelligence Applied in Adaptive Manufacturing Process Monitoring: A State-of-the-Art in the Era of Automation. Procedia Comput. Sci. 2025, 256, 47–54. [Google Scholar] [CrossRef]
  182. Taheri, H.; Salimi Beni, A. Artificial Intelligence, Machine Learning, and Smart Technologies for Nondestructive Evaluation. In Handbook of Nondestructive Evaluation 4.0; Springer Nature: Cham, Switzerland, 2025; pp. 1–29. ISBN 9783030482008. [Google Scholar]
  183. Bustillo, A.; Karlis, A. Artificial Intelligence in Fault Diagnosis and Signal Processing. Appl. Sci. 2025, 15, 3922. [Google Scholar] [CrossRef]
  184. Islam, M.M.M.; Emon, J.I.; Ng, K.Y.; Asadpour, A.; Aziz, M.M.R.A.; Baptista, M.L.; Kim, J.-M. Artificial Intelligence in Smart Manufacturing: Emerging Opportunities and Prospects. In Springer Series in Advanced Manufacturing; Springer Nature: Cham, Switzerland, 2025; pp. 9–36. ISBN 9783031801532. [Google Scholar]
  185. Babashahi, L.; Barbosa, C.E.; Lima, Y.; Lyra, A.; Salazar, H.; Argôlo, M.; Almeida, M.A.d.; Souza, J.M.d. AI in the Workplace: A Systematic Review of Skill Transformation in the Industry. Adm. Sci. 2024, 14, 127. [Google Scholar] [CrossRef]
  186. Martini, B.; Bellisario, D.; Coletti, P. Human-Centered and Sustainable Artificial Intelligence in Industry 5.0: Challenges and Perspectives. Sustainability 2024, 16, 5448. [Google Scholar] [CrossRef]
  187. Banerjee, A.; Haridas, H.K.; SenGupta, A.; Jabalia, N. Artificial Intelligence in 3D Printing: A Revolution in Health Care. In Lecture Notes in Bioengineering; Springer: Singapore, 2022; pp. 57–79. ISBN 9789813367029. [Google Scholar]
  188. Kanthimathi, T.; Rathika, N.; Fathima, A.J.; Rajesh; Srinivasan, S.; Thamizhamuthu, R. Robotic 3D Printing for Customized Industrial Components: IoT and AI-Enabled Innovation. In Proceedings of the 2024 14th International Conference on Cloud Computing, Noida, India, 18–19 January 2024; pp. 509–513. [Google Scholar]
  189. Johnson, M.; Jain, R.; Brennan-Tonetta, P.; Swartz, E.; Silver, D.; Paolini, J.; Mamonov, S.; Hill, C. Impact of Big Data and Artificial Intelligence on Industry: Developing a Workforce Roadmap for a Data Driven Economy. Glob. J. Flex. Syst. Manag. 2021, 22, 197–217. [Google Scholar] [CrossRef]
  190. Tyagi, A.K.; Bhatt, P.; Chidambaram, N.; Kumari, S. Artificial Intelligence Empowered Smart Manufacturing for Modern Society: A Review. In Artificial Intelligence-Enabled Digital Twin for Smart Manufacturing; John Wiley & Sons, Inc.: Hoboken, NJ, USA, 2024; pp. 55–83. [Google Scholar]
  191. Shaji George, A.; Hovan George, A.S.; Baskar, T. The Evolution of Smart Factories: How Industry 5.0 Is Revolutionizing Manufacturing. Zenodo 2023, 1, 33–53. [Google Scholar] [CrossRef]
  192. Sadeghi, S.; Canty, R.B.; Mukhin, N.; Xu, J.; Delgado-Licona, F.; Abolhasani, M. Engineering a Sustainable Future: Harnessing Automation, Robotics, and Artificial Intelligence with Self-Driving Laboratories. ACS Sustain. Chem. Eng. 2024, 12, 12695–12707. [Google Scholar] [CrossRef]
  193. Goh, G.D.; Sing, S.L.; Yeong, W.Y. A Review on Machine Learning in 3D Printing: Applications, Potential, and Challenges. Artif. Intell. Rev. 2021, 54, 63–94. [Google Scholar] [CrossRef]
  194. Zhang, X.; Chu, D.; Zhao, X.; Gao, C.; Lu, L.; He, Y.; Bai, W. Machine Learning-Driven 3D Printing: A Review. Appl. Mater. Today 2024, 39, 102306. [Google Scholar] [CrossRef]
  195. Farhan Khan, M.; Alam, A.; Ateeb Siddiqui, M.; Saad Alam, M.; Rafat, Y.; Salik, N.; Al-Saidan, I. Real-Time Defect Detection in 3D Printing Using Machine Learning. Mater. Today 2021, 42, 521–528. [Google Scholar] [CrossRef]
  196. Ali, A.; Riaz, R.D.; Malik, U.J.; Abbas, S.B.; Usman, M.; Shah, M.U.; Kim, I.-H.; Hanif, A.; Faizan, M. Machine Learning-Based Predictive Model for Tensile and Flexural Strength of 3D-Printed Concrete. Materials 2023, 16, 4149. [Google Scholar] [CrossRef]
  197. Singh, R.; Kumar, R.; Farina, I.; Colangelo, F.; Feo, L.; Fraternali, F. Multi-Material Additive Manufacturing of Sustainable Innovative Materials and Structures. Polymers 2019, 11, 62. [Google Scholar] [CrossRef]
  198. Khatri, B.; Frey, M.; Raouf-Fahmy, A.; Scharla, M.-V.; Hanemann, T. Development of a Multi-Material Stereolithography 3D Printing Device. Micromachines 2020, 11, 532. [Google Scholar] [CrossRef]
  199. Afshar, A.; Wood, R. Development of Weather-Resistant 3D Printed Structures by Multi-Material Additive Manufacturing. J. Compos. Sci. 2020, 4, 94. [Google Scholar] [CrossRef]
  200. Valentine, A.D.; Busbee, T.A.; Boley, J.W.; Raney, J.R.; Chortos, A.; Kotikian, A.; Berrigan, J.D.; Durstock, M.F.; Lewis, J.A. Hybrid 3D Printing of Soft Electronics. Adv. Mater. 2017, 29. [Google Scholar] [CrossRef]
  201. Mikolajczyk, T.; Malinowski, T.; Moldovan, L.; Fuwen, H.; Paczkowski, T.; Ciobanu, I. CAD CAM System for Manufacturing Innovative Hybrid Design Using 3D Printing. Procedia Manuf. 2019, 32, 22–28. [Google Scholar] [CrossRef]
  202. Apeiranthitis, S.; Zacharia, P.; Chatzopoulos, A.; Papoutsidakis, M. Predictive Maintenance of Machinery with Rotating Parts Using Convolutional Neural Networks. Electronics 2024, 13, 460. [Google Scholar] [CrossRef]
  203. Omairi, A.; Ismail, Z.H. Towards Machine Learning for Error Compensation in Additive Manufacturing. Appl. Sci. 2021, 11, 2375. [Google Scholar] [CrossRef]
  204. Çınar, Z.M.; Abdussalam Nuhu, A.; Zeeshan, Q.; Korhan, O.; Asmael, M.; Safaei, B. Machine Learning in Predictive Maintenance towards Sustainable Smart Manufacturing in Industry 4.0. Sustainability 2020, 12, 8211. [Google Scholar] [CrossRef]
  205. Sampedro, G.A.R.; Rachmawati, S.M.; Kim, D.-S.; Lee, J.-M. Exploring Machine Learning-Based Fault Monitoring for Polymer-Based Additive Manufacturing: Challenges and Opportunities. Sensors 2022, 22, 9446. [Google Scholar] [CrossRef]
  206. Kadam, V.; Kumar, S.; Bongale, A.; Wazarkar, S.; Kamat, P.; Patil, S. Enhancing Surface Fault Detection Using Machine Learning for 3D Printed Products. Appl. Syst. Innov. 2021, 4, 34. [Google Scholar] [CrossRef]
  207. Heymann, H.; Schmitt, R.H. Machine Learning Pipeline for Predictive Maintenance in Polymer 3D Printing. Procedia CIRP 2023, 117, 341–346. [Google Scholar] [CrossRef]
  208. Kantaros, A.; Piromalis, D.; Tsaramirsis, G.; Papageorgas, P.; Tamimi, H. 3D Printing and Implementation of Digital Twins: Current Trends and Limitations. Appl. Syst. Innov. 2021, 5, 7. [Google Scholar] [CrossRef]
  209. Herzog, T.; Brandt, M.; Trinchi, A.; Sola, A.; Molotnikov, A. Process Monitoring and Machine Learning for Defect Detection in Laser-Based Metal Additive Manufacturing. J. Intell. Manuf. 2024, 35, 1407–1437. [Google Scholar] [CrossRef]
  210. Rojek, I.; Kopowski, J.; Lewandowski, J.; Mikołajewski, D. Use of Machine Learning to Improve Additive Manufacturing Processes. Appl. Sci. 2024, 14, 6730. [Google Scholar] [CrossRef]
  211. Dostatni, E.; Osiński, F.; Mikołajewski, D.; Sapietová, A.; Rojek, I. Neural Networks for Prediction of 3D Printing Parameters for Reducing Particulate Matter Emissions and Enhancing Sustainability. Sustainability 2024, 16, 8616. [Google Scholar] [CrossRef]
  212. Pagac, M.; Hajnys, J.; Ma, Q.-P.; Jancar, L.; Jansa, J.; Stefek, P.; Mesicek, J. A Review of Vat Photopolymerization Technology: Materials, Applications, Challenges, and Future Trends of 3D Printing. Polymers 2021, 13, 598. [Google Scholar] [CrossRef] [PubMed]
  213. Madla, C.M.; Trenfield, S.J.; Goyanes, A.; Gaisford, S.; Basit, A.W. 3D Printing Technologies, Implementation and Regulation: An Overview. In AAPS Advances in the Pharmaceutical Sciences Series; Springer International Publishing: Cham, Switzerland, 2018; pp. 21–40. ISBN 9783319907543. [Google Scholar]
  214. Taylor, A.A.; Freeman, E.L.; van der Ploeg, M.J.C. Regulatory Developments and Their Impacts to the Nano-Industry: A Case Study for Nano-Additives in 3D Printing. Ecotoxicol. Environ. Saf. 2021, 207, 111458. [Google Scholar] [CrossRef] [PubMed]
  215. Wu, L.; Dong, Z. Interfacial Regulation for 3D Printing Based on Slice-Based Photopolymerization. Adv. Mater. 2023, 35, e2300903. [Google Scholar] [CrossRef] [PubMed]
  216. Paxton, N.C. Navigating the Intersection of 3D Printing, Software Regulation and Quality Control for Point-of-Care Manufacturing of Personalized Anatomical Models. 3D Print. Med. 2023, 9, 9. [Google Scholar] [CrossRef]
  217. Montes, J. Risks and Regulation of Emerging Technologies in Chaotic and Uncertain Times the Case of 3D Printing. In Proceedings of the 2017 International Conference on Infocom Technologies and Unmanned Systems (Trends and Future Directions) (ICTUS), Dubai, United Arab Emirates, 18–20 December 2017. [Google Scholar]
  218. Daly, A. Medical 3D Printing, Intellectual Property, and Regulation. In 3D Printing in Medicine; Elsevier: Amsterdam, The Netherlands, 2023; pp. 385–398. ISBN 9780323898317. [Google Scholar]
  219. Osborn, L. 3D Printing and Intellectual Property. In Research Handbook on Digital Transformations; Cambridge University Press: Cambridge, UK, 2016; pp. 254–271. [Google Scholar]
  220. OECD 2017—The next Production Revolution- Implications for Governments and Business—Ch.5 Only.Pdf. Available online: https://drive.google.com/file/d/1H--DA7R97HWhmeXeGXEZyvfWQFLOLLuh/view (accessed on 16 April 2025).
  221. Khosravani, M.R.; Reinicke, T. On the Environmental Impacts of 3D Printing Technology. Appl. Mater. Today 2020, 20, 100689. [Google Scholar] [CrossRef]
  222. Jovanović, M.; Sanguino, T.d.J.M.; Damjanović, M.; Đukanović, M.; Thomopoulos, N. Driving Sustainability: Carbon Footprint, 3D Printing, and Legislation Concerning Electric and Autonomous Vehicles. Sensors 2023, 23, 9104. [Google Scholar] [CrossRef]
Figure 1. Synergy between 3D printing and automation.
Figure 1. Synergy between 3D printing and automation.
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Figure 2. ECCO company reduces product development time by incorporating Stratasys Origin One 3D printers (3D print outsole).
Figure 2. ECCO company reduces product development time by incorporating Stratasys Origin One 3D printers (3D print outsole).
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Figure 3. Challenges in integrating 3D printing with automation.
Figure 3. Challenges in integrating 3D printing with automation.
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Table 1. Case studies demonstrating the synergy between 3D printing, automation, and AI in manufacturing.
Table 1. Case studies demonstrating the synergy between 3D printing, automation, and AI in manufacturing.
Case Study/ReferenceTechnology EmployedApplication AreaKey Benefits
Dabbagh et al. [82]Machine Learning in Extrusion-based 3D PrintingProcess OptimizationReal-time parameter adjustment, improved print quality, reduced waste
Elbadawi et al. [83]Conditional Generative Adversarial Networks (cGANs)Material FormulationNovel FDM material development, reduced trial-and-error, accelerated innovation
Yang [84]Case-Based Reasoning SystemsPrint Quality EnhancementKnowledge reuse, optimized printing parameters, reduced manual adjustments
Melton Machine & Control Co. [85]SLS 3D PrintingWelding Fixture ComponentsCustom switch housings with enhanced durability and thermal resistance
Lengyel (PrintMax Solutions) [86]AI-Driven Workflow AutomationEnd-to-End Print Services40% reduction in production time, 30% fewer errors, improved customer satisfaction
Nguyen et al. [87]Robotics with Deep LearningPost-Processing (Decaking)Automated powder removal, enhanced scalability, reduced manual labor
Table 2. Advantages of integrating 3D printing and automation in manufacturing processes.
Table 2. Advantages of integrating 3D printing and automation in manufacturing processes.
Key BenefitDescriptionImpact on ManufacturingExamples/Applications
Customization at ScaleAbility to produce personalized products without increasing cost or production time.Enables personalized products in high volumes, meeting specific consumer needs while maintaining production efficiency.Customized footwear (e.g., Adidas and Nike), custom medical devices, personalized consumer goods.
Reduced Material WasteThree-dimensional printing’s additive process uses only the required material, minimizing waste.Reduces material consumption and environmental footprint, while optimizing production processes.Aerospace parts, custom automotive components, 3D-printed prosthetics.
Sustainability through Efficient Resource UseReal-time optimization of material and energy usage via automation.Improves sustainability by reducing material waste, energy consumption, and excess inventory.Energy-efficient manufacturing in automotive and healthcare sectors, local production of goods.
Enhanced Just-in-Time (JIT) ManufacturingOn-demand production using digital inventory and automated systems.Reduces inventory costs, enables quick responses to market demand, and decreases overproduction.Automotive parts, consumer electronics, on-demand production of complex parts.
Improved Digital Inventory ManagementDigital designs are stored and produced on-demand, reducing reliance on physical stock.Reduces the need for extensive physical inventories and logistics, lowering costs.Spare parts for machinery, customized products (e.g., shoes, medical implants).
Decentralized Manufacturing and Local ProductionProduction can be moved closer to the point of use, enhancing supply chain resilience.Shortens lead times, reduces transportation costs, and mitigates the risks associated with global supply chains.Localized manufacturing in industries like healthcare, automotive, and consumer goods.
Table 3. Key challenges in integrating 3D printing with automated manufacturing systems.
Table 3. Key challenges in integrating 3D printing with automated manufacturing systems.
ChallengeDescriptionImpact on ManufacturingPotential Solutions
Quality Control and RepeatabilityVariability in material properties, print layer adhesion, and machine calibration can lead to inconsistent part quality.Inconsistent quality across large production runs, affecting product reliability.Advanced sensor integration, AI-driven real-time monitoring, and process optimization.
ScalabilityThree-dimensional printing is typically slower than traditional manufacturing methods, limiting its ability to scale in high-volume production.Slower production rates compared to conventional methods, hindering large-scale applications.Hybrid manufacturing systems, multi-printer configurations, and optimized post-processing workflows.
Compatibility with Existing SystemsIntegration of 3D printing with traditional automated systems (e.g., robotic arms, CNC machines) requires significant modification.Disruption to existing workflows and difficulty in synchronizing additive and subtractive processes.Development of standardized software and hardware interfaces for seamless integration.
Workforce AdaptationAI and machine learning technologies in 3D printing systems require workers to adapt to new roles and skill sets.Potential job displacement and need for reskilling in high-tech areas such as AI and robotics.Investment in workforce training programs and skill development in emerging technologies.
Table 4. Emerging trends and regulatory considerations in the future of automated 3D printing.
Table 4. Emerging trends and regulatory considerations in the future of automated 3D printing.
Trend/ConsiderationDescriptionImpact on Automated 3D Printing
AI-Driven Self-Optimizing PrintersIntegration of AI to optimize print parameters in real-time based on environmental and process data.Enhanced print quality, reduced waste, and increased production efficiency.
Predictive MaintenanceUse of machine learning algorithms to predict printer failures and schedule maintenance.Minimizes downtime and reduces operational costs by preventing unexpected machine failures.
Multi-Material PrintingAbility to print using multiple materials within a single part, optimizing material distribution based on part function.Increases versatility and functionality of printed parts, especially for complex geometries requiring varied material properties.
Hybrid Manufacturing SystemsCombining additive (3D printing) and subtractive processes (e.g., CNC machining) in a single system.Enables high precision and complex part fabrication, balancing the strengths of both 3D printing and traditional manufacturing.
Standardization and Regulatory FrameworksDevelopment of international standards for 3D printing materials, processes, and quality assurance.Ensures part quality, consistency, and safety, enabling broader adoption across industries with confidence in product reliability.
Intellectual Property (IP) RegulationsRegulatory frameworks addressing the protection of digital designs and ensuring secure sharing of 3D printing files.Addresses IP challenges raised by digital fabrication and ensures secure and legal reproduction of designs.
Environmental RegulationsGuidelines to minimize the environmental impact of 3D printing, including sustainable material use and recycling practices.Promotes eco-friendly practices in 3D printing, reducing waste and encouraging the use of biodegradable or recyclable materials.
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Kantaros, A.; Drosos, C.; Papoutsidakis, M.; Pallis, E.; Ganetsos, T. The Role of 3D Printing in Advancing Automated Manufacturing Systems: Opportunities and Challenges. Automation 2025, 6, 21. https://doi.org/10.3390/automation6020021

AMA Style

Kantaros A, Drosos C, Papoutsidakis M, Pallis E, Ganetsos T. The Role of 3D Printing in Advancing Automated Manufacturing Systems: Opportunities and Challenges. Automation. 2025; 6(2):21. https://doi.org/10.3390/automation6020021

Chicago/Turabian Style

Kantaros, Antreas, Christos Drosos, Michail Papoutsidakis, Evangelos Pallis, and Theodore Ganetsos. 2025. "The Role of 3D Printing in Advancing Automated Manufacturing Systems: Opportunities and Challenges" Automation 6, no. 2: 21. https://doi.org/10.3390/automation6020021

APA Style

Kantaros, A., Drosos, C., Papoutsidakis, M., Pallis, E., & Ganetsos, T. (2025). The Role of 3D Printing in Advancing Automated Manufacturing Systems: Opportunities and Challenges. Automation, 6(2), 21. https://doi.org/10.3390/automation6020021

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