The Prevalence of Helicobacter pylori Infection in the Adult Population of Russia: A Systematic Review and Meta-Analysis
Abstract
1. Introduction
2. Materials and Methods
2.1. Study Sources and Search
2.2. Study Selection
2.3. Data Extraction
2.4. Statistical Analysis
3. Results
3.1. Search Results
3.2. The Prevalence of H. pylori in Russia
3.3. Meta-Regression
3.4. Subgroup Analysis
3.5. Sensitivity Analysis
4. Discussion
4.1. Main Findings
4.2. Limitations
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
GC | Gastric cancer |
PRISMA | Preferred Reporting Items for Systematic Reviews and Meta-Analyses |
PROSPERO | International Prospective Register of Systematic Reviews |
RSCI | Russian Science Citation Index |
NOS | Newcastle–Ottawa scale |
H. Pylori | Helicobacter pylori |
CI | Confidence interval |
MRSA | Methicillin-resistant Staphylococcus aureus |
WHO | World Health Organization |
IARC | International Agency for Research on Cancer |
MALT | Mucosa-associated lymphoid tissue |
Hp-EuReg | Helicobacter pylori European Registry |
ET | Eradication therapy |
PPI | Proton pump inhibitor |
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Study, Year | Methodology of H. pylori Diagnostic | Geographical Location | Total Number of Patients, n | Total Number of Patients with H. pylori | Mean Age, Years | Period of Inquiry | NOS Criteria Score |
---|---|---|---|---|---|---|---|
Reshetnikov et al., 2001 [17] | Serology | Novosibirsk | 438 | 387 | 44.36 ± 16.38 | 1994–1995 | 8 |
Shtygasheva et al., 2004 [18] | Four methods (morphological, urease breath test, polymerase chain reaction in biopsy, serological testing) | Khakassia Republic | 4217 | 3625 | not available | 2004 | 3 |
Kostyunin et al., 2009 [19] | Examination of gastrobiopathology (histologically and cytologically) | Irkutsk Region | 2324 | 1836 | 44.36 ± 0.33 | 2001–2006 | 6 |
Lazebnik et al., 2010 [20] | 13C-urea breath test | Moscow | 300 | 182 | 56.6 ± 15.3 | 2006 | 7 |
Herman et al., 2012 [21] | Serology | Moscow | 863 | 759 | not available | 2011 | 6 |
Rakhmanin et al., 2014 [22] | Serology | Moscow | 2414 | 2182 | not available | 2013 | 5 |
Svarval et al., 2014 [23] | Serology | Saint Petersburg | 1057 | 688 | not available | 2007–2011 | 7 |
Rabinovich et al., 2015 [24] | Serology | Ural Federal District | 100 | 85 | 58.6 ± 15 | 2015 | 7 |
Bakulina et al., 2017 [15] | 13C-urea breath test | Multicenter Research | 2098 (of these, 127 patients in Moscow; 74 in Kazan; 448 in Saint Petersburg; 26 in Novosibirsk; and 10 in other cities) | 1157 (of these, 61 patients in Moscow; 38 in Kazan; 227 in Saint Petersburg; 17 in Novosibirsk; and 10 in other cities) | 48 ± 13.5 | 2016–2017 | 7 |
Reshetnikov et al., 2018 [25] | Serology | Novosibirsk | 168 | 97 | not available | 2003–2005 | 5 |
90 | 56 | 2013–2015 | |||||
Khripach et al., 2018 [26] | Serology | Moscow | 319 | 271 | 42 ± 14.07 | 2017 | 7 |
Zhestkova et al., 2019 [27] | Serology | Ryazan Region | 809 | 531 | 57.38 ± 11.63 | 2017–2018 | 8 |
Plavnik et al., 2019 [28] | 13C-urea breath test | Kazan and Moscow | 286 | 162 | 38 ± 12.5 | 2019 | 7 |
Abdulova et al., 2021 [29] | 13C-urea breath test | Multicenter Research | 26,127 | 10,190 | 42.9 ± 17.8 | 2019–2020 | 7 |
Bordin et al., 2022 [10] | 13C-urea breath test | Multicenter Research | 10,225 | 3669 | 43.65 ± 15.5 | 2017 | 9 |
9650 | 3431 | 2019 | |||||
Bakulina et al., 2023 [30] | 13C-urea breath test | Saint Petersburg | 8553 | 3537 | 43.76 ± 15.73 | 2015–2017 | 8 |
33,990 | 11,821 | 2018–2023 | |||||
Khlynova et al., 2023 [31] | 13C-urea breath test | Ural Federal District | 9939 | 4733 | 42.95 ± 17.77 | 2018–2022 | 7 |
Bordin et al., 2024 [32] | 13C-urea breath test | Moscow | 3124 | 1162 | not available | 2022 | 6 |
Kaprin et al., 2024 [33] | Serology | Moscow | 434 | 188 | 48.5 ± 0.6 | 2024 | 7 |
Luzina et al., 2024 [34] | Detection of H. pylori antigen in feces by single-stage immunochromatographic analysis | Zabaykalsky Krai | 316 | 93 | 46.83 ± 14.66 | 2019–2023 | 7 |
Diagnostic Method | Before 2005, % | 2005–2011, % | 2012–2017, % | 2018–2024, % |
---|---|---|---|---|
Serology | 74.625 (95% CI: 40.693–96.927) | 77.533 (95% CI: 52.005–95.139) | 78.677 (95% CI: 61.839–86.248) | 54.650 (95% CI: 32.892–75.514) |
13C-urea breath test | No data | 60.667 (95% CI: 54.889–66.231) | 45.404 (95% CI: 27.197–64.272) | 41.097 (95% CI: 37.038–45.218) |
Study | Sampling Population | ROBINS-I Risk of Bias (Participant Selection) [52] |
---|---|---|
Reshetnikov et al., 2001 [17] | General population | Low risk |
Shtygasheva et al., 2004 [18] | Multiple population groups | Moderate risk |
Kostyunin et al., 2009 [19] | Gastroenterology patients | High risk |
Lazebnik et al., 2010 [20] | General population | Low risk |
Herman et al., 2012 [21] | General population | Low risk |
Rakhmanin et al., 2014 [22] | General population | Low risk |
Svarval et al., 2014 [23] | Gastroenterology patients | High risk |
Rabinovich et al., 2015 [24] | Multiple population groups | Moderate risk |
Bakulina et al., 2017 [15] | Healthcare workers | High risk |
Reshetnikov et al., 2018 [25] | General population | Low risk |
Khripach et al., 2018 [26] | General population | Low risk |
Zhestkova et al., 2019 [27] | Multiple population groups | Moderate risk |
Plavnik et al., 2019 [28] | General population | Low risk |
Abdulova et al., 2021 [29] | General population | Low risk |
Bordin et al., 2022 [10] | General population | Low risk |
Bakulina et al., 2023 [30] | General population | Low risk |
Khlynova et al., 2023 [31] | Gastroenterology patients | High risk |
Bordin et al., 2024 [32] | General population | Low risk |
Kaprin et al., 2024 [33] | Healthcare workers | High risk |
Luzina et al., 2024 [34] | General population | Low risk |
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Andreev, D.N.; Khurmatullina, A.R.; Maev, I.V.; Bordin, D.S.; Abdulkhakov, S.R.; Kucheryavyy, Y.A.; Beliy, P.A.; Sokolov, F.S. The Prevalence of Helicobacter pylori Infection in the Adult Population of Russia: A Systematic Review and Meta-Analysis. Epidemiologia 2025, 6, 47. https://doi.org/10.3390/epidemiologia6030047
Andreev DN, Khurmatullina AR, Maev IV, Bordin DS, Abdulkhakov SR, Kucheryavyy YA, Beliy PA, Sokolov FS. The Prevalence of Helicobacter pylori Infection in the Adult Population of Russia: A Systematic Review and Meta-Analysis. Epidemiologia. 2025; 6(3):47. https://doi.org/10.3390/epidemiologia6030047
Chicago/Turabian StyleAndreev, Dmitrii N., Alsu R. Khurmatullina, Igor V. Maev, Dmitry S. Bordin, Sayar R. Abdulkhakov, Yury A. Kucheryavyy, Petr A. Beliy, and Filipp S. Sokolov. 2025. "The Prevalence of Helicobacter pylori Infection in the Adult Population of Russia: A Systematic Review and Meta-Analysis" Epidemiologia 6, no. 3: 47. https://doi.org/10.3390/epidemiologia6030047
APA StyleAndreev, D. N., Khurmatullina, A. R., Maev, I. V., Bordin, D. S., Abdulkhakov, S. R., Kucheryavyy, Y. A., Beliy, P. A., & Sokolov, F. S. (2025). The Prevalence of Helicobacter pylori Infection in the Adult Population of Russia: A Systematic Review and Meta-Analysis. Epidemiologia, 6(3), 47. https://doi.org/10.3390/epidemiologia6030047